Copper(II)-Mediated Cascade Oxidative C–C Coupling and Aromatization: Synthesis of 3-Hydroxyphenanthridinone Derivatives

Abstract

A novel copper(II) acetate mediated synthesis of 3-hydroxyphenanthridin-6(5H)-ones from N-(3-oxocyclohex-1-enyl)benzamides was developed. The process is postulated to involve an intramolecular oxidative C(sp²)–C(sp³) bond formation followed by dehydrogenative aromatization.

Key words

copper(II) acetate - phenanthridinone - C–H functionalization - C–C oxidative coupling - dehydrogenative aromatization

• References


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