Three-Component Condensation for the Construction of Novel Spirooxindoles

Abstract

A new route for the synthesis of novel spirooxindoles from isocyanides, dialkyl acetylenedicarboxylates, and N-substituted isatylidene derivatives through [3+2] cycloaddition has been developed. This method has several advantages, such as high regioselectivity, high yields, readily available starting materials, and one-pot operations. The synthetic alkyne-containing spirooxindoles could also be used in the selective synthesis of triazole-containing­ spirocyclic compounds using a copper azide–alkyne cycloaddition­ (CuAAC) reaction.

Key words

multicomponent reaction - spirooxindoles - [3+2] cycloaddition - CuAAC reaction - triazoles

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