One-Pot, Four-Component Synthesis of Novel Imidazo[2,1-b]thiazol-5-amine Derivatives

Abstract

Novel imidazo[2,1-b]thiazol-5-amine derivatives were synthesized by a one-pot, four-component reaction of 2-bromoacetophenone derivatives, aromatic aldehydes, thiourea, and isocyanides in the presence of ammonium chloride (NH₄Cl) in toluene under reflux conditions. Moderate to good yields resulted and the reaction showed tolerance toward a range of aromatic aldehydes with electron-donating and electron-withdrawing substituents on either­ para or ortho positions.

Key words

heterocyclic compounds - multicomponent reactions - isocyanides - thiourea - ammonium chloride

• References

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