Resistance Exercise Enhances Cognitive Function in Mouse

K. Suijo; S. Inoue; Y. Ohya; Y. Odagiri; T. Takamiya; H. Ishibashi; M. Itoh; Y. Fujieda; T. Shimomitsu

doi:10.1055/s-0032-1323747

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2013; 34(04): 368-375
DOI: 10.1055/s-0032-1323747

Genetics & Molecular Biology

Resistance Exercise Enhances Cognitive Function in Mouse

K. Suijo

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

S. Inoue

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

Y. Ohya

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

Y. Odagiri

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

T. Takamiya

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

H. Ishibashi

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

,

M. Itoh

²Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

,

Y. Fujieda

³Department of Health and Sports Sciences, Tokyo Gakugei University, Tokyo, Japan

,

T. Shimomitsu

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan

› Author Affiliations

Abstract

Physical exercise has been shown to increase adult neurogenesis in the hippocampus and to enhance synaptic plasticity. It has been demonstrated that these neuroprotective effects can be observed following aerobic exercise. However, it remains unknown whether plasticity molecules, such as brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB), are expressed in the hippocampus following resistance exercise. We applied voluntary progressive-resistance wheel exercise (RE) for 14 days, and measured BDNF and CREB in the hippocampus. The Morris water maze was also performed to estimate learning and memory. Furthermore, we measured RE effects on mammalian target of rapamycin (mTOR) and 70-kDa ribosomal protein S6 kinase (p70S6K) mediating muscle protein synthesis in the soleus. As a result, we found that RE enhanced cognition and elevated BDNF and CREB expressions in the hippocampus. Also, RE activated the mTOR-p70S6K signaling pathway in the soleus. We found that phosphorylated mTOR and p70S6K were significantly positively correlated with BDNF expression. Our results indicated that resistance exercise drove the protein synthesis signaling pathway in the soleus and enhanced hippocampal synaptic plasticity-related molecules. These results suggest the beneficial effects of resistance exercise on cognitive function.

Key words

resistance exercise - cognition - brain-derived neurotrophic factor - cyclic AMP response element-binding protein - mammalian target of rapamycin - 70-kDa ribosomal protein S6 kinase

Full Text

References

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