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Facial Plast Surg 2012; 28(05): 525-535
DOI: 10.1055/s-0032-1325641
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Botulinum Toxin to Minimize Facial Scarring

Eric M. Jablonka
1   Department of Surgery, Division of Plastic and Reconstructive Surgery, The Mount Sinai Hospital, New York, New York
,
David A. Sherris
2   Department of Otolaryngology–Head and Neck Surgery, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York
,
Holger G. Gassner
3   Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany
› Author Affiliations
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Publication History

Publication Date:
01 October 2012 (online)

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Abstract

Chemoimmobilization with botulinum toxin A is an ideal biochemical agent that allows near-total elimination of muscle pull on the healing facial wound. The goal of chemoimmobilization of facial cutaneous wounds is to eliminate dynamic tension on the healing tissues to improve wound healing and minimize scarring for optimal aesthetic results.

Keywords

botulinum toxin - chemoimmobilization - scar - wound healing - facial scar
 

  • References

  • 1 Kane M. Botulinum toxin. In: Thorne C, Beasley R, Aston S, Bartlett S, Gurtner G, Spear S, , eds. Grabb & Smith's Plastic Surgery. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007: 475-479
    Google Scholar
  • 2 Scott AB, Rosenbaum A, Collins CC. Pharmacologic weakening of extraocular muscles. Invest Ophthalmol 1973; 12: 924-927
    PubMedGoogle Scholar
  • 3 Scott AB. Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology 1980; 87: 1044-1049
    CrossrefPubMedGoogle Scholar
  • 4 Clark RP, Berris CE. Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis. Plast Reconstr Surg 1989; 84: 353-355
    CrossrefPubMedGoogle Scholar
  • 5 Carruthers JDA, Carruthers JA. Treatment of glabellar frown lines with clostridium botulinum A exotoxin. Dermatol Surg 1992; 18: 17-21
    PubMedGoogle Scholar
  • 6 Gassner HG, Sherris DA, Otley CC. Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates. Plast Reconstr Surg 2000; 105: 1948-1953 ; discussion 1954–1955
    CrossrefPubMedGoogle Scholar
  • 7 Gassner HG, Brissett AE, Otley CC , et al. Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study. Mayo Clin Proc 2006; 81: 1023-1028
    CrossrefPubMedGoogle Scholar
  • 8 Zimbler MS, Holds JB, Kokoska MS , et al. Effect of botulinum toxin pretreatment on laser resurfacing results: a prospective, randomized, blinded trial. Arch Facial Plast Surg 2001; 3: 165-169
    CrossrefPubMedGoogle Scholar
  • 9 Bansal C, Omlin KJ, Hayes CM, Rohrer TE. Novel cutaneous uses for botulinum toxin type A. J Cosmet Dermatol 2006; 5: 268-272
    CrossrefPubMedGoogle Scholar
  • 10 Laskawi R. [Botulinum toxin treatment in the head and neck region: current aspects, developments, and problems]. HNO 2007; 55 (6) 437-442
    CrossrefPubMedGoogle Scholar
  • 11 Arnon SS, Schechter R, Inglesby TV , et al; Working Group on Civilian Biodefense. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2001; 285: 1059-1070
    CrossrefPubMedGoogle Scholar
  • 12 Scott A. Clostridial toxins as therapeutic agents. In: Simpson LL, , ed. Botulinum Neurotoxin and Tetanus Toxin. New York, NY: Academic Press; 1989: 399-412
    CrossrefGoogle Scholar
  • 13 Blitzer A, Binder WJ, Aviv JE, Keen MS, Brin MF. The management of hyperfunctional facial lines with botulinum toxin. A collaborative study of 210 injection sites in 162 patients. Arch Otolaryngol Head Neck Surg 1997; 123: 389-392
    PubMedGoogle Scholar
  • 14 Carruthers A, Carruthers J. Botulinum toxin type A: history and current cosmetic use in the upper face. Semin Cutan Med Surg 2001; 20: 71-84
    CrossrefPubMedGoogle Scholar
  • 15 Due E, Rossen K, Sorensen LT, Kliem A, Karlsmark T, Haedersdal M. Effect of UV irradiation on cutaneous cicatrices: a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations. Acta Derm Venereol 2007; 87: 27-32
    CrossrefPubMedGoogle Scholar
  • 16 Mandal A. Do malnutrition and nutritional supplementation have an effect on the wound healing process?. J Wound Care 2006; 15: 254-257
    PubMedGoogle Scholar
  • 17 Sherris DA, Larrabee Jr WF, Murakami CS. Management of scar contractures, hypertrophic scars, and keloids. Otolaryngol Clin North Am 1995; 28: 1057-1068
    PubMedGoogle Scholar
  • 18 Larrabee Jr WF, Sutton D. The biomechanics of advancement and rotation flaps. Laryngoscope 1981; 91: 726-734
    PubMedGoogle Scholar
  • 19 Larrabee Jr WF, Trachy R, Sutton D, Cox K. Rhomboid flap dynamics. Arch Otolaryngol 1981; 107: 755-757
    CrossrefPubMedGoogle Scholar
  • 20 Cloquet JH. Traite d'Anatomie Descriptive. Paris, France: Libraire de Crochard; 1832: 313
    Google Scholar
  • 21 Dupuytren G. Traite Theorique et Pratique des. Armes de Guerre. Paris. Baillere 1834; 2: 60-66
    PubMedGoogle Scholar
  • 22 Langer K. On the anatomy and physiology of the skin: I. The cleavability of the skin. Br J Plast Surg 1978; 31 (4) 277-278
    PubMedGoogle Scholar
  • 23 Larrabee Jr WF, Sherris DA. Principles of Facial Reconstruction. Philadelphia, PA: Lippincott-Raven; 1995: 7
    Google Scholar
  • 24 McCarthy JG. Plastic Surgery. Philadelphia: W.B. Saunders; 1990: 43-44
    Google Scholar
  • 25 Sherris DA, Gassner HG. Botulinum toxin to minimize facial scarring. Facial Plast Surg 2002; 18: 35-39
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Lee BJ, Jeong JH, Wang SG, Lee JC, Goh EK, Kim HW. Effect of botulinum toxin type A on a rat surgical wound model. Clin Exp Otorhinolaryngol 2009; 2: 20-27
    CrossrefPubMedGoogle Scholar
  • 27 Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746
    CrossrefPubMedGoogle Scholar
  • 28 Woodley DT, Chen JD, Kim JP , et al. Re-epithelialization. Human keratinocyte locomotion. Dermatol Clin 1993; 11: 641-646
    PubMedGoogle Scholar
  • 29 Clark RAF , Ed. The Molecular and Cellular Biology of Wound Repair. 2nd ed. New York, NY: Plenum Press; 1996
    Google Scholar
  • 30 Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975; 78: 71-100
    PubMedGoogle Scholar
  • 31 Hunt TK , Ed. Wound Healing and Wound Infection: Theory and Surgical Practice. New York, NY: Appleton-Century-Crofts; 1980
    Google Scholar
  • 32 Taylor JA. Wound healing. In: Blueprints Plastic Surgery. Malden, MA: Blackwell Publishing; 2005: 17-31
    Google Scholar
  • 33 Gassner HG, Sherris DA. Chemoimmobilization: improving predictability in the treatment of facial scars. Plast Reconstr Surg 2003; 112: 1464-1466
    CrossrefPubMedGoogle Scholar
  • 34 Wilson AM. Use of botulinum toxin type A to prevent widening of facial scars. Plast Reconstr Surg 2006; 117: 1758-1766 ; discussion 1767–1768
    CrossrefPubMedGoogle Scholar
  • 35 Gassner HG, Sherris DA, Friedman O. Botulinum toxin-induced immobilization of lower facial wounds. Arch Facial Plast Surg 2009; 11: 140-142
    PubMedGoogle Scholar
  • 36 Tollefson TT, Senders CM, Sykes JM, Byorth PJ. Botulinum toxin to improve results in cleft lip repair. Arch Facial Plast Surg 2006; 8: 221-222
    CrossrefPubMedGoogle Scholar
  • 37 Gassner HG, Sherris DA. Addition of an anesthetic agent to enhance the predictability of the effects of botulinum toxin type A injections: a randomized controlled study. Mayo Clin Proc 2000; 75: 701-704
    PubMedGoogle Scholar
  • 38 Gassner HG, Sherris DA, Moe KS , et al. The role of botulinum toxin in wound healing. In: Jankovic J, Albanese A, Atassi MZ, , et al, eds. Botulinum Toxin, Therapeutic Clinical Practice & Science. Philadelphia, PA: Elsevier Saunders Inc.; 2009: 339-348
    CrossrefGoogle Scholar