Regenerative Medicine for Congenital Diaphragmatic Hernia: Regeneration for Repair

Paolo De Coppi; Jan Deprest

doi:10.1055/s-0032-1329410

European Journal of Pediatric Surgery, Table of Contents

Eur J Pediatr Surg 2012; 22(05): 393-398
DOI: 10.1055/s-0032-1329410

Review

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Regenerative Medicine for Congenital Diaphragmatic Hernia: Regeneration for Repair

Paolo De Coppi

¹Surgery Unit, Great Ormond Street Hospital, Institute of Child Health, UCL Stem Cell Centre, University College London, London, United Kingdom

,

Jan Deprest

²Department of Development and Regeneration, Research Unit Fetus Placenta Neonate, Faculty of Medicine, Division of Woman and Child, University Hospital Gasthuisberg, Leuven, Belgium

› Author Affiliations

Abstract

Regenerative medicine has developed recently as a new field of science aiming at restoring organ and tissue damage through the use of autologous constructs. Cellular therapies and relatively simple tissue engineering reconstructions have recently been successfully applied into patients. For babies born with congenital diaphragmatic hernia, regenerative medicine may play a role both in developing a myogenic patch capable of restoring muscle function and promoting regeneration of hypoplastic lungs that characterised those patients. The latter is particularly attractive because it may change the long-term outcome of those children. We aim here to discuss recent advancement in the field, looking in particular at the future clinical prospective of those exciting therapeutic strategies.

Keywords

congenital diaphragmatic hernia - regenerative medicine - newborns

Full Text

References

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