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Eur J Pediatr Surg 2012; 22(05): 374-383
DOI: 10.1055/s-0032-1329531
DOI: 10.1055/s-0032-1329531
Review
Management of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia
Weitere Informationen
Publikationsverlauf
10. September 2012
17. September 2012
Publikationsdatum:
31. Oktober 2012 (online)
Abstract
Pulmonary hypertension associated with congenital diaphragmatic hernia is still one of the major challenges in neonatal intensive care units. Several relevant pathways in its pathogenesis have been described and studied, but the absence of well-designed randomized controlled trials and the scattered data on the pharmacokinetics and pharmacodynamics of most of the drugs used in these patients hamper progress significantly. This review aims to give an overview of current management strategies in the antenatal and neonatal phase, and provides founded clinical recommendations.
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References
- 1 Lally KP, Engle W. American Academy of Pediatrics Section on Surgery; American Academy of Pediatrics Committee on Fetus and Newborn. Postdischarge follow-up of infants with congenital diaphragmatic hernia. Pediatrics 2008; 121 (3) 627-632
- 2 Bagolan P, Morini F. Long-term follow up of infants with congenital diaphragmatic hernia. Semin Pediatr Surg 2007; 16 (2) 134-144
- 3 Trachsel D, Selvadurai H, Bohn D, Langer JC, Coates AL. Long-term pulmonary morbidity in survivors of congenital diaphragmatic hernia. Pediatr Pulmonol 2005; 39 (5) 433-439
- 4 van den Hout L, Schaible T, Cohen-Overbeek TE , et al. Actual outcome in infants with congenital diaphragmatic hernia: the role of a standardized postnatal treatment protocol. Fetal Diagn Ther 2011; 29 (1) 55-63
- 5 Jeffery TK, Wanstall JC. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacol Ther 2001; 92 (1) 1-20
- 6 Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 2006; 99 (7) 675-691
- 7 Okoye BO, Losty PD, Fisher MJ, Wilmott I, Lloyd DA. Effect of dexamethasone on endothelial nitric oxide synthase in experimental congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed 1998; 78 (3) F204-F208
- 8 Abman SH, Ivy DD. Recent progress in understanding pediatric pulmonary hypertension. Curr Opin Pediatr 2011; 23 (3) 298-304
- 9 Giaid A, Yanagisawa M, Langleben D , et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993; 328 (24) 1732-1739
- 10 Kobayashi H, Puri P. Plasma endothelin levels in congenital diaphragmatic hernia. J Pediatr Surg 1994; 29 (9) 1258-1261
- 11 de Lagausie P, de Buys-Roessingh A, Ferkdadji L , et al. Endothelin receptor expression in human lungs of newborns with congenital diaphragmatic hernia. J Pathol 2005; 205 (1) 112-118
- 12 Dingemann J, Doi T, Ruttenstock E, Puri P. Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation. Pediatr Surg Int 2010; 26 (1) 65-69
- 13 Rosenberg AA, Kennaugh J, Koppenhafer SL, Loomis M, Chatfield BA, Abman SH. Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension. J Pediatr 1993; 123 (1) 109-114
- 14 Datin-Dorriere V, Rouzies S, Taupin P , et al. Prenatal prognosis in isolated congenital diaphragmatic hernia. Am J Obstet Gynecol 2008; 198 (1) 80 , e1–e5
- 15 Deprest J, Jani J, Van Schoubroeck D , et al. Current consequences of prenatal diagnosis of congenital diaphragmatic hernia. J Pediatr Surg 2006; 41 (2) 423-430
- 16 Keller RL. Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management. Am J Med Genet C Semin Med Genet 2007; 145C (2) 184-200
- 17 Jani J, Keller RL, Benachi A , et al; Antenatal-CDH-Registry Group. Prenatal prediction of survival in isolated left-sided diaphragmatic hernia. Ultrasound Obstet Gynecol 2006; 27 (1) 18-22
- 18 Ba'ath ME, Jesudason EC, Losty PD. How useful is the lung-to-head ratio in predicting outcome in the fetus with congenital diaphragmatic hernia? A systematic review and meta-analysis. Ultrasound Obstet Gynecol 2007; 30 (6) 897-906
- 19 Metkus AP, Filly RA, Stringer MD, Harrison MR, Adzick NS. Sonographic predictors of survival in fetal diaphragmatic hernia. J Pediatr Surg 1996; 31 (1) 148-151 , discussion 151–152
- 20 Jani J, Nicolaides KH, Keller RL , et al; Antenatal-CDH-Registry Group. Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia. Ultrasound Obstet Gynecol 2007; 30 (1) 67-71
- 21 Ruano R, Benachi A, Martinovic J , et al. Can three-dimensional ultrasound be used for the assessment of the fetal lung volume in cases of congenital diaphragmatic hernia?. Fetal Diagn Ther 2004; 19 (1) 87-91
- 22 Peralta CF, Jani J, Cos T, Nicolaides KH, Deprest J. Left and right lung volumes in fetuses with diaphragmatic hernia. Ultrasound Obstet Gynecol 2006; 27 (5) 551-554
- 23 Harrison MR, Langer JC, Adzick NS , et al. Correction of congenital diaphragmatic hernia in utero, V. Initial clinical experience. J Pediatr Surg 1990; 25 (1) 47-55 , discussion 56–57
- 24 Mullassery D, Ba'ath ME, Jesudason EC, Losty PD. Value of liver herniation in prediction of outcome in fetal congenital diaphragmatic hernia: a systematic review and meta-analysis. Ultrasound Obstet Gynecol 2010; 35 (5) 609-614
- 25 Ruano R, Takashi E, da Silva MM, Campos JA, Tannuri U, Zugaib M. Prediction and probability of neonatal outcome in isolated congenital diaphragmatic hernia using multiple ultrasound parameters. Ultrasound Obstet Gynecol 2012; 39 (1) 42-49
- 26 Sokol J, Shimizu N, Bohn D, Doherty D, Ryan G, Hornberger LK. Fetal pulmonary artery diameter measurements as a predictor of morbidity in antenatally diagnosed congenital diaphragmatic hernia: a prospective study. Am J Obstet Gynecol 2006; 195 (2) 470-477
- 27 Thébaud B, Azancot A, de Lagausie P , et al. Congenital diaphragmatic hernia: antenatal prognostic factors. Does cardiac ventricular disproportion in utero predict outcome and pulmonary hypoplasia?. Intensive Care Med 1997; 23 (10) 10062-10069
- 28 Coakley FV, Lopoo JB, Lu Y , et al. Normal and hypoplastic fetal lungs: volumetric assessment with prenatal single-shot rapid acquisition with relaxation enhancement MR imaging. Radiology 2000; 216 (1) 107-111
- 29 Rypens F, Metens T, Rocourt N , et al. Fetal lung volume: estimation at MR imaging-initial results. Radiology 2001; 219 (1) 236-241
- 30 Mahieu-Caputo D, Sonigo P, Dommergues M , et al. Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia. BJOG 2001; 108 (8) 863-868
- 31 Cannie M, Jani J, Meersschaert J , et al. Prenatal prediction of survival in isolated diaphragmatic hernia using observed to expected total fetal lung volume determined by magnetic resonance imaging based on either gestational age or fetal body volume. Ultrasound Obstet Gynecol 2008; 32 (5) 633-639
- 32 Ruano R, Aubry MC, Barthe B, Mitanchez D, Dumez Y, Benachi A. Quantitative analysis of fetal pulmonary vasculature by 3-dimensional power Doppler ultrasonography in isolated congenital diaphragmatic hernia. Am J Obstet Gynecol 2006; 195 (6) 1720-1728
- 33 Mahieu-Caputo D, Aubry MC, El Sayed M, Joubin L, Thalabard JC, Dommergues M. Evaluation of fetal pulmonary vasculature by power Doppler imaging in congenital diaphragmatic hernia. J Ultrasound Med 2004; 23 (8) 1011-1017
- 34 Fuke S, Kanzaki T, Mu J , et al. Antenatal prediction of pulmonary hypoplasia by acceleration time/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry. Am J Obstet Gynecol 2003; 188 (1) 228-233
- 35 Chaoui R, Kalache K, Tennstedt C, Lenz F, Vogel M. Pulmonary arterial Doppler velocimetry in fetuses with lung hypoplasia. Eur J Obstet Gynecol Reprod Biol 1999; 84 (2) 179-185
- 36 Cruz-Martinez R, Moreno-Alvarez O, Hernandez-Andrade E , et al. Contribution of intrapulmonary artery Doppler to improve prediction of survival in fetuses with congenital diaphragmatic hernia treated with fetal endoscopic tracheal occlusion. Ultrasound Obstet Gynecol 2010; 35 (5) 572-577
- 37 Laudy JA, Gaillard JL, vd Anker JN, Tibboel D, Wladimiroff JW. Doppler ultrasound imaging: a new technique to detect lung hypoplasia before birth?. Ultrasound Obstet Gynecol 1996; 7 (3) 189-192
- 38 Moreno-Alvarez O, Hernandez-Andrade E, Oros D, Jani J, Deprest J, Gratacos E. Association between intrapulmonary arterial Doppler parameters and degree of lung growth as measured by lung-to-head ratio in fetuses with congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2008; 31 (2) 164-170
- 39 Cruz-Martinez R, Hernandez-Andrade E, Moreno-Alvarez O, Done E, Deprest J, Gratacos E. Prognostic value of pulmonary Doppler to predict response to tracheal occlusion in fetuses with congenital diaphragmatic hernia. Fetal Diagn Ther 2011; 29 (1) 18-24
- 40 Broth RE, Wood DC, Rasanen J , et al. Prenatal prediction of lethal pulmonary hypoplasia: the hyperoxygenation test for pulmonary artery reactivity. Am J Obstet Gynecol 2002; 187 (4) 940-945
- 41 Done E, Allegaert K, Lewi P , et al. Maternal hyperoxygenation test in fetuses undergoing FETO for severe isolated congenital diaphragmatic hernia. Ultrasound Obstet Gynecol 2011; 37 (3) 264-271
- 42 Stressig R, Fimmers R, Eising K, Gembruch U, Kohl T. Preferential streaming of the ductus venosus and inferior caval vein towards the right heart is associated with left heart underdevelopment in human fetuses with left-sided diaphragmatic hernia. Heart 2010; 96 (19) 1564-1568
- 43 Suen HC, Bloch KD, Donahoe PK. Antenatal glucocorticoid corrects pulmonary immaturity in experimentally induced congenital diaphragmatic hernia in rats. Pediatr Res 1994; 35 (5) 523-529
- 44 Suen HC, Losty P, Donahoe PK, Schnitzer JJ. Combined antenatal thyrotropin-releasing hormone and low-dose glucocorticoid therapy improves the pulmonary biochemical immaturity in congenital diaphragmatic hernia. J Pediatr Surg 1994; 29 (2) 359-363
- 45 Guarino N, Puri P. Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats. J Pediatr Surg 2002; 37 (11) 1563-1567
- 46 Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consens Statement 1994; 12 (2) 1-24
- 47 Lally KP, Bagolan P, Hosie S , et al; Congenital Diaphragmatic Hernia Study Group. Corticosteroids for fetuses with congenital diaphragmatic hernia: can we show benefit?. J Pediatr Surg 2006; 41 (4) 668-674 , discussion 668–674
- 48 DiFiore JW, Fauza DO, Slavin R, Peters CA, Fackler JC, Wilson JM. Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia. J Pediatr Surg 1994; 29 (2) 248-256 , discussion 256–257
- 49 Khan PA, Cloutier M, Piedboeuf B. Tracheal occlusion: a review of obstructing fetal lungs to make them grow and mature. Am J Med Genet C Semin Med Genet 2007; 145C (2) 125-138
- 50 Harrison MR, Keller RL, Hawgood SB , et al. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 2003; 349 (20) 1916-1924
- 51 Breysem L, Debeer A, Claus F , et al. Cross-sectional study of tracheomegaly in children after fetal tracheal occlusion for severe congenital diaphragmatic hernia. Radiology 2010; 257 (1) 226-232
- 52 Deprest J, Breysem L, Gratacos E , et al. Tracheal side effects following fetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia. Pediatr Radiol 2010; 40 (5) 670-673
- 53 Deprest J, Nicolaides K, Done' E , et al. Technical aspects of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia. J Pediatr Surg 2011; 46 (1) 22-32
- 54 Reiss I, Schaible T, van den Hout L , et al; CDH EURO Consortium. Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus. Neonatology 2010; 98 (4) 354-364
- 55 Davis PG, Tan A, O'Donnell CP, Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet 2004; 364 (9442) 1329-1333
- 56 Pejovic B, Peco-Antic A, Marinkovic-Eric J. Blood pressure in non-critically ill preterm and full-term neonates. Pediatr Nephrol 2007; 22 (2) 249-257
- 57 Carbajal R, Eble B, Anand KJ. Premedication for tracheal intubation in neonates: confusion or controversy?. Semin Perinatol 2007; 31 (5) 309-317
- 58 Masumoto K, Nagata K, Uesugi T, Yamada T, Taguchi T. Risk factors for sensorineural hearing loss in survivors with severe congenital diaphragmatic hernia. Eur J Pediatr 2007; 166 (6) 607-612
- 59 Keller RL, Tacy TA, Hendricks-Munoz K , et al. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med 2010; 182 (4) 555-561
- 60 Dillon PW, Cilley RE, Mauger D, Zachary C, Meier A. The relationship of pulmonary artery pressure and survival in congenital diaphragmatic hernia. J Pediatr Surg 2004; 39 (3) 307-312 , discussion 307–312
- 61 Reisner SA, Azzam Z, Halmann M , et al. Septal/free wall curvature ratio: a noninvasive index of pulmonary arterial pressure. J Am Soc Echocardiogr 1994; 7 (1) 27-35
- 62 Dong SJ, Smith ER, Tyberg JV. Changes in the radius of curvature of the ventricular septum at end diastole during pulmonary arterial and aortic constrictions in the dog. Circulation 1992; 86 (4) 1280-1290
- 63 Takahashi S, Oishi Y, Ito N , et al. Evaluating mortality and disease severity in congenital diaphragmatic hernia using the McGoon and pulmonary artery indices. J Pediatr Surg 2009; 44 (11) 2101-2106
- 64 Boloker J, Bateman DA, Wung JT, Stolar CJ. Congenital diaphragmatic hernia in 120 infants treated consecutively with permissive hypercapnea/spontaneous respiration/elective repair. J Pediatr Surg 2002; 37 (3) 357-366
- 65 Logan JW, Cotten CM, Goldberg RN, Clark RH. Mechanical ventilation strategies in the management of congenital diaphragmatic hernia. Semin Pediatr Surg 2007; 16 (2) 115-125
- 66 Wung JT, Sahni R, Moffitt ST, Lipsitz E, Stolar CJ. Congenital diaphragmatic hernia: survival treated with very delayed surgery, spontaneous respiration, and no chest tube. J Pediatr Surg 1995; 30 (3) 406-409
- 67 Bagolan P, Casaccia G, Crescenzi F, Nahom A, Trucchi A, Giorlandino C. Impact of a current treatment protocol on outcome of high-risk congenital diaphragmatic hernia. J Pediatr Surg 2004; 39 (3) 313-318 , discussion 313–318
- 68 Downard CD, Jaksic T, Garza JJ , et al. Analysis of an improved survival rate for congenital diaphragmatic hernia. J Pediatr Surg 2003; 38 (5) 729-732
- 69 Finer NN, Tierney A, Etches PC, Peliowski A, Ainsworth W. Congenital diaphragmatic hernia: developing a protocolized approach. J Pediatr Surg 1998; 33 (9) 1331-1337
- 70 Frenckner B, Ehrén H, Granholm T, Lindén V, Palmér K. Improved results in patients who have congenital diaphragmatic hernia using preoperative stabilization, extracorporeal membrane oxygenation, and delayed surgery. J Pediatr Surg 1997; 32 (8) 1185-1189
- 71 Kays DW, Langham Jr MR, Ledbetter DJ, Talbert JL. Detrimental effects of standard medical therapy in congenital diaphragmatic hernia. Ann Surg 1999; 230 (3) 340-348 , discussion 348–351
- 72 Reyes C, Chang LK, Waffarn F, Mir H, Warden MJ, Sills J. Delayed repair of congenital diaphragmatic hernia with early high-frequency oscillatory ventilation during preoperative stabilization. J Pediatr Surg 1998; 33 (7) 1010-1014 , discussion 1014–1016
- 73 Weber TR, Kountzman B, Dillon PA, Silen ML. Improved survival in congenital diaphragmatic hernia with evolving therapeutic strategies. Arch Surg 1998; 133 (5) 498-502 , discussion 502–503
- 74 Wilson JM, Lund DP, Lillehei CW, Vacanti JP. Congenital diaphragmatic hernia—a tale of two cities: the Boston experience. J Pediatr Surg 1997; 32 (3) 401-405
- 75 Bohn D. Congenital diaphragmatic hernia. Am J Respir Crit Care Med 2002; 166 (7) 911-915
- 76 Ssemakula N, Stewart DL, Goldsmith LJ, Cook LN, Bond SJ. Survival of patients with congenital diaphragmatic hernia during the ECMO era: an 11-year experience. J Pediatr Surg 1997; 32 (12) 1683-1689
- 77 Osiovich HC. Improving survival of neonates with isolated congenital diaphragmatic hernia. Indian Pediatr 2004; 41 (11) 1138-1142
- 78 Somaschini M, Locatelli G, Salvoni L, Bellan C, Colombo A. Impact of new treatments for respiratory failure on outcome of infants with congenital diaphragmatic hernia. Eur J Pediatr 1999; 158 (10) 780-784
- 79 Cacciari A, Ruggeri G, Mordenti M , et al. High-frequency oscillatory ventilation versus conventional mechanical ventilation in congenital diaphragmatic hernia. Eur J Pediatr Surg 2001; 11 (1) 3-7
- 80 Henderson-Smart DJ, De Paoli AG, Clark RH, Bhuta T. High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term. Cochrane Database Syst Rev 2009; (3) CD002974
- 81 van den Hout L, Tibboel D, Vijfhuize S, te Beest H, Hop W, Reiss I. CDH-EURO Consortium. The VICI-trial: high frequency oscillation versus conventional mechanical ventilation in newborns with congenital diaphragmatic hernia: an international multicentre randomized controlled trial. BMC Pediatr 2011; 11: 98
- 82 Ng PC, Lee CH, Bnur FL , et al. A double-blind, randomized, controlled study of a “stress dose” of hydrocortisone for rescue treatment of refractory hypotension in preterm infants. Pediatrics 2006; 117 (2) 367-375
- 83 Steinhorn RH. Therapeutic approaches using nitric oxide in infants and children. Free Radic Biol Med 2011; 51 (5) 1027-1034
- 84 Finer NN, Etches PC, Kamstra B, Tierney AJ, Peliowski A, Ryan CA. Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response. J Pediatr 1994; 124 (2) 302-308
- 85 Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340 (8823) 819-820
- 86 Finer NN, Barrington KJ. Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev 2001; (4) CD000399
- 87 The Neonatal Inhaled Nitric Oxide Study Group (NINOS). Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. Pediatrics 1997; 99 (6) 838-845
- 88 Fineman JR, Zwass MS. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn 1995; 37 (4) 425-430
- 89 Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS. Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med 2003; 29 (11) 1996-2003
- 90 Baquero H, Soliz A, Neira F, Venegas ME, Sola A. Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study. Pediatrics 2006; 117 (4) 1077-1083
- 91 Noori S, Friedlich P, Wong P, Garingo A, Seri I. Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension. Neonatology 2007; 91 (2) 92-100
- 92 Hunter L, Richens T, Davis C, Walker G, Simpson JH. Sildenafil use in congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed 2009; 94 (6) F467
- 93 De Luca D, Zecca E, Vento G, De Carolis MP, Romagnoli C. Transient effect of epoprostenol and sildenafil combined with iNO for pulmonary hypertension in congenital diaphragmatic hernia. Paediatr Anaesth 2006; 16 (5) 597-598
- 94 Filan PM, McDougall PN, Shekerdemian LS. Combination pharmacotherapy for severe neonatal pulmonary hypertension. J Paediatr Child Health 2006; 42 (4) 219-220
- 95 Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med 2006; 7 (6) 589-594
- 96 Ahsman MJ, Witjes BC, Wildschut ED , et al. Sildenafil exposure in neonates with pulmonary hypertension after administration via a nasogastric tube. Arch Dis Child Fetal Neonatal Ed 2010; 95 (2) F109-F114
- 97 Luong C, Rey-Perra J, Vadivel A , et al. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 2011; 123 (19) 2120-2131
- 98 McNamara PJ, Laique F, Muang-In S, Whyte HE. Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. J Crit Care 2006; 21 (2) 217-222
- 99 Bassler D, Kreutzer K, McNamara P, Kirpalani H. Milrinone for persistent pulmonary hypertension of the newborn. Cochrane Database Syst Rev 2010; (11) CD007802
- 100 Patel N. Use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients. Neonatology 2012; 102 (2) 130-136
- 101 De Luca D, Zecca E, Piastra M, Romagnoli C. Iloprost as 'rescue' therapy for pulmonary
hypertension of the neonate. Paediatr Anaesth 2007; 17 (4) 394-395
MissingFormLabel
- 102 Ehlen M, Wiebe B. Iloprost in persistent pulmonary hypertension of the newborn. Cardiol
Young 2003; 13 (4) 361-363
MissingFormLabel
- 103 Inamura N, Kubota A, Nakajima T , et al. A proposal of new therapeutic strategy for antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg 2005; 40 (8) 1315-1319
- 104 Konduri GG. New approaches for persistent pulmonary hypertension of newborn. Clin Perinatol 2004; 31 (3) 591-611
- 105 Sun YJ, Xiong CM, Shan GL , et al; Iloprost Therapy on Pulmonary Hypertension Study Group. Inhaled low-dose iloprost for pulmonary hypertension: a prospective, multicenter, open-label study. Clin Cardiol 2012; 35 (6) 365-370
- 106 Hill LL, Pearl RG. Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension. J Appl Physiol 1999; 86 (4) 1160-1164
- 107 Hoeper MM, Galiè N, Simonneau G, Rubin LJ. New treatments for pulmonary arterial hypertension. Am J Respir Crit Care Med 2002; 165 (9) 1209-1216
- 108 Bos AP, Tibboel D, Koot VC, Hazebroek FW, Molenaar JC. Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: incidence and vasodilator therapy. J Pediatr Surg 1993; 28 (11) 1463-1465
- 109 Mulligan C, Beghetti M. Inhaled iloprost for the control of acute pulmonary hypertension in children: a systematic review. Pediatr Crit Care Med 2011; 13 (4) 472-480
- 110 Mohseni-Bod H, Bohn D. Pulmonary hypertension in congenital diaphragmatic hernia. Semin Pediatr Surg 2007; 16 (2) 126-133
- 111 Shiyanagi S, Okazaki T, Shoji H , et al. Management of pulmonary hypertension in congenital diaphragmatic hernia: nitric oxide with prostaglandin-E1 versus nitric oxide alone. Pediatr Surg Int 2008; 24 (10) 1101-1104
- 112 Nakwan N, Choksuchat D, Saksawad R, Thammachote P, Nakwan N. Successful treatment of persistent pulmonary hypertension of the newborn with bosentan. Acta Paediatr 2009; 98 (10) 1683-1685
- 113 Souza R, Sitbon O, Parent F, Simonneau G, Humbert M. Long term imatinib treatment in pulmonary arterial hypertension. Thorax 2006; 61 (8) 736
- 114 Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 2005; 353 (13) 1412-1413
- 115 Mathew R. PDGF receptor blocker for pulmonary hypertension: a new agent in therapeutic arsenal. Expert Opin Investig Drugs 2012; 21 (2) 139-142
- 116 ten Freyhaus H, Dumitrescu D, Berghausen E, Vantler M, Caglayan E, Rosenkranz S. Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs 2012; 21 (1) 119-134
- 117 Abe K, Toba M, Alzoubi A , et al. Tyrosine kinase inhibitors are potent acute pulmonary vasodilators in rats. Am J Respir Cell Mol Biol 2011; 45 (4) 804-808
- 118 Frenckner B, Broomé M, Lindström M, Radell P. Platelet-derived growth factor inhibition—a new treatment of pulmonary hypertension in congenital diaphragmatic hernia?. J Pediatr Surg 2008; 43 (10) 1928-1931
- 119 Chang YT, Ringman Uggla A, Osterholm C , et al. Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 2012; 302 (11) L1159-L1166
- 120 Langham Jr MR, Kays DW, Beierle EA , et al. Twenty years of progress in congenital diaphragmatic hernia at the University of Florida. Am Surg 2003; 69 (1) 45-52
- 121 Van Meurs KP, Newman KD, Anderson KD, Short BL. Effect of extracorporeal membrane oxygenation on survival of infants with congenital diaphragmatic hernia. J Pediatr 1990; 117 (6) 954-960
- 122 Morini F, Goldman A, Pierro A. Extracorporeal membrane oxygenation in infants with congenital diaphragmatic hernia: a systematic review of the evidence. Eur J Pediatr Surg 2006; 16 (6) 385-391
- 123 Mugford M, Elbourne D, Field D. Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants. Cochrane Database Syst Rev 2008; (3) CD001340
- 124 Wildschut ED, Ahsman MJ, Houmes RJ , et al. Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO). Curr Drug Metab 2012; 13 (6) 767-777