Living-Donor Liver Transplantation: Current Perspective

Steven Lobritto; Tomoaki Kato; Jean Emond

doi:10.1055/s-0032-1329900

Seminars in Liver Disease, Inhaltsverzeichnis

Semin Liver Dis 2012; 32(04): 333-340
DOI: 10.1055/s-0032-1329900

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Living-Donor Liver Transplantation: Current Perspective

Autoren

Steven Lobritto

¹Department of Pediatrics and Internal Medicine, NY Presbyterian Hospital–Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, New York
Tomoaki Kato

²Department of Surgery, NY Presbyterian Hospital, Columbia University Medical Center, New York, New York
Jean Emond

²Department of Surgery, NY Presbyterian Hospital, Columbia University Medical Center, New York, New York

Abstract

The disparity between the number of available deceased liver donors and the number of patients awaiting transplantation continues to be an ongoing issue predisposing to death on the liver transplant waiting list. Deceased donor shortage strategies including the use of extended donor-criteria deceased donor grafts, split liver transplants, and organs harvested after cardiac death have fallen short of organ demand. Efforts to raise donor awareness are ongoing, but the course has been arduous to date. Living donor transplantation is a means to access an unlimited donor organ supply and offers potential advantages to deceased donation. Donor safety remains paramount demanding improvements and innovations in both the donor and recipient operations to ensure superior outcomes. The specialty operation is best preformed at centers with specific expertise and shuttling of select patients to these centers supported by third party payers is critical. Training future surgeons at centers with this specific experience can help disseminate this technology to improve local availability. Ongoing research in immunosuppression minimization, withdrawal and tolerance induction may make living donation a desired first-line operation rather than a necessary albeit less-desirable option. This chapter summarizes the progress of living liver donation and its potential applications.

Keywords

living donation - liver transplantation

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Referenzen

References
1 Broelsch CE, Emond JC, Whitington PF, Thistlethwaite JR, Baker AL, Lichtor JL. Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg 1990; 212 (3) 368-375 , discussion 375–377
2 Raia S, Nery JR, Mies S. Liver transplantation from live donors. Lancet 1989; 2 (8661) 497
3 Hwang S, Lee SG, Lee YJ , et al. Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl 2006; 12 (6) 920-927
4 Kaido T, Egawa H, Tsuji H, Ashihara E, Maekawa T, Uemoto S. In-hospital mortality in adult recipients of living donor liver transplantation: experience of 576 consecutive cases at a single center. Liver Transpl 2009; 15 (11) 1420-1425
5 Kim SH, Cho SY, Park SJ , et al. Learning curve for living-donor liver transplantation in a fledgling cancer center. Transpl Int 2009; 22 (12) 1164-1171
6 Tiao GM, Alonso MH, Ryckman FC. Pediatric liver transplantation. Semin Pediatr Surg 2006; 15 (3) 218-227
7 Yersiz H, Cameron AM, Carmody I , et al. Split liver transplantation. Transplant Proc 2006; 38 (2) 602-603
8 Goss JA, Yersiz H, Shackleton CR , et al. In situ splitting of the cadaveric liver for transplantation. Transplantation 1997; 64 (6) 871-877
9 Singer PA, Siegler M, Lantos JD , et al. The ethical assessment of innovative therapies: liver transplantation using living donors. Theor Med 1990; 11 (2) 87-94
10 Miller CM, Smith ML, Diago Uso T. Living donor liver transplantation: ethical considerations. Mt Sinai J Med 2012; 79 (2) 214-222
11 Millis JM, Alonso EM, Piper JB , et al. Liver transplantation at the University of Chicago. Clin Transpl 1995; 187-197
12 Olthoff KM, Merion RM, Ghobrial RM , et al; A2ALL Study Group. Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium. Ann Surg 2005; 242 (3) 314-323 , discussion 323–325
13 Freise CE, Gillespie BW, Koffron AJ , et al; A2ALL Study Group. Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL Retrospective Cohort Study. Am J Transplant 2008; 8 (12) 2569-2579
14 Hashikura Y, Makuuchi M, Kawasaki S , et al. Successful living-related partial liver transplantation to an adult patient. Lancet 1994; 343 (8907) 1233-1234
15 Lo CM, Fan ST, Liu CL , et al. Adult-to-adult living donor liver transplantation using extended right lobe grafts. Ann Surg 1997; 226 (3) 261-269 , discussion 269–270
16 Cowles RA, Lobritto SJ, Ventura KA , et al. Timing of liver transplantation in biliary atresia-results in 71 children managed by a multidisciplinary team. J Pediatr Surg 2008; 43 (9) 1605-1609
17 Freeman Jr RB, Wiesner RH, Roberts JP, McDiarmid S, Dykstra DM, Merion RM. Improving liver allocation: MELD and PELD. Am J Transplant 2004; 4 (Suppl. 09) 114-131
18 Berg CL, Merion RM, Shearon TH , et al. Liver transplant recipient survival benefit with living donation in the model for endstage liver disease allocation era. Hepatology 2011; 54 (4) 1313-1321
19 Hu Z, Wang W, Li Z, Ye S, Zheng S. Recipient outcomes of salvage liver transplantation versus primary liver transplantation: a systematic review and meta-analysis. Liver Transpl 2012; . [Epub ahead of print]
20 Browne M, Sher D, Grant D , et al. Survival after liver transplantation for hepatoblastoma: a 2-center experience. J Pediatr Surg 2008; 43 (11) 1973-1981
21 Ismail H, Broniszczak D, Kaliciński P , et al. Changing treatment and outcome of children with hepatoblastoma: analysis of a single center experience over the last 20 years. J Pediatr Surg 2012; 47 (7) 1331-1339
22 Ito T, Takada Y, Ueda M , et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation. Liver Transpl 2007; 13 (12) 1637-1644
23 Lee SG, Hwang S, Moon DB , et al. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. Liver Transpl 2008; 14 (7) 935-945
24 Mazzaferro V, Llovet JM, Miceli R , et al; Metroticket Investigator Study Group. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol 2009; 10 (1) 35-43
25 Terrault NA, Shiffman ML, Lok AS , et al; A2ALL Study Group. Outcomes in hepatitis C virus-infected recipients of living donor vs. deceased donor liver transplantation. Liver Transpl 2007; 13 (1) 122-129
26 Everson GT, Terrault NA, Lok AS , et al; A2ALL Study. A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation. Hepatology 2012; . [Epub ahead of print]
27 Pons JA, Revilla Nuin B, Ramírez P , et al. What do we know about the clinical impact of complete withdrawal of immunosuppression in liver transplantation?. Transplant Proc 2012; 44 (6) 1530-1532
28 Mazariegos GV, Reyes J, Marino IR , et al. Weaning of immunosuppression in liver transplant recipients. Transplantation 1997; 63 (2) 243-249
29 Feng S, Ekong UD, Lobritto SJ , et al. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA 2012; 307 (3) 283-293
30 Whitington PF, Rubin CM, Alonso EM , et al. Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor. Transplantation 1996; 62 (10) 1516-1519
31 Abecassis MM, Fisher RA, Olthoff KM , et al; A2ALL Study Group. Complications of living donor hepatic lobectomy—a comprehensive report. Am J Transplant 2012; 12 (5) 1208-1217
32 Ozgor D, Dirican A, Ates M, Gönültas F, Ara C, Yilmaz S. Donor complications among 500 living donor liver transplantations at a single center. Transplant Proc 2012; 44 (6) 1604-1607
33 Tamura S, Sugawara Y, Kaneko J , et al. Systematic grading of surgical complications in live liver donors according to Clavien's system. Transpl Int 2006; 19 (12) 982-987
34 Malagó M, Rogiers X, Burdelski M, Broelsch CE. Living related liver transplantation: 36 cases at the University of Hamburg. Transplant Proc 1994; 26 (6) 3620-3621
35 Hashikura Y, Ichida T, Umeshita K , et al; Japanese Liver Transplantation Society. Donor complications associated with living donor liver transplantation in Japan. Transplantation 2009; 88 (1) 110-114
36 Brown Jr RS. Live donors in liver transplantation. Gastroenterology 2008; 134 (6) 1802-1813
37 Holtzman S, Adcock L, Dubay DA , et al. Financial, vocational, and interpersonal impact of living liver donation. Liver Transpl 2009; 15 (11) 1435-1442
38 DuBay DA, Holtzman S, Adcock L , et al. Adult right-lobe living liver donors: quality of life, attitudes and predictors of donor outcomes. Am J Transplant 2009; 9 (5) 1169-1178
39 Lee SH, Lim KC, Jeon MK , et al. Postoperative pain and influencing factors among living liver donors. Transplant Proc 2012; 44 (2) 363-365
40 Takada Y, Suzukamo Y, Oike F , et al. Long-term quality of life of donors after living donor liver transplantation. Liver Transpl 2012; . [Epub ahead of print]
41 Delair S, Feeley TH, Kim H , et al. A peer-based intervention to educate liver transplant candidates about living donor liver transplantation. Liver Transpl 2010; 16 (1) 42-48
42 Chisuwa H, Hashikura Y, Mita A , et al. Living liver donation: preoperative assessment, anatomic considerations, and long-term outcome. Transplantation 2003; 75 (10) 1670-1676
43 Hill MJ, Hughes M, Jie T , et al. Graft weight/recipient weight ratio: how well does it predict outcome after partial liver transplants?. Liver Transpl 2009; 15 (9) 1056-1062
44 Selzner M, Kashfi A, Cattral MS , et al. A graft to body weight ratio less than 0.8 does not exclude adult-to-adult right-lobe living donor liver transplantation. Liver Transpl 2009; 15 (12) 1776-1782
45 Cherqui D, Soubrane O, Husson E , et al. Laparoscopic living donor hepatectomy for liver transplantation in children. Lancet 2002; 359 (9304) 392-396
46 Yu YD, Kim KH, Jung DH, Lee SG, Kim YG, Hwang GS. Laparoscopic live donor left lateral sectionectomy is safe and feasible for pediatric living donor liver transplantation. Hepatogastroenterology 2012; 59 (120) . [Epub ahead of print]
47 Ong TH, Strong R, Zahari Z , et al. The management of difficult abdominal closure after pediatric liver transplantation. J Pediatr Surg 1996; 31 (2) 295-296
48 Renz JF, Rosenthal P, Roberts JP, Ascher NL, Emond JC. Planned exploration of pediatric liver transplant recipients reduces posttransplant morbidity and lowers length of hospitalization. Arch Surg 1997; 132 (9) 950-955 , discussion 955–956
49 Wang SF, Huang ZY, Chen XP. Biliary complications after living donor liver transplantation. Liver Transpl 2011; 17 (10) 1127-1136
50 Berg CL, Gillespie BW, Merion RM , et al; A2ALL Study Group. Improvement in survival associated with adult-to-adult living donor liver transplantation. Gastroenterology 2007; 133 (6) 1806-1813
51 Jiang SM, Zhou GW, Zhang R , et al. Role of splanchnic hemodynamics in liver regeneration after living donor liver transplantation. Liver Transpl 2009; 15 (9) 1043-1049
52 Humar A, Beissel J, Crotteau S, Cohen M, Lake J, Payne WD. Delayed splenic artery occlusion for treatment of established small-for-size syndrome after partial liver transplantation. Liver Transpl 2009; 15 (2) 163-168
53 Sato Y, Yamamoto S, Oya H , et al. Splenectomy for reduction of excessive portal hypertension after adult living-related donor liver transplantation. Hepatogastroenterology 2002; 49 (48) 1652-1655
54 Jabbour N, Gagandeep S, Mateo R, Sher L, Selby R, Genyk Y. Left portahepatic shunt: a novel technique to decrease excessive portal venous inflow during live donor liver transplantation. J Am Coll Surg 2003; 197 (6) 1056-1057
55 Takada Y, Ueda M, Ishikawa Y , et al. End-to-side portocaval shunting for a small-for-size graft in living donor liver transplantation. Liver Transpl 2004; 10 (6) 807-810
56 Troisi R, Ricciardi S, Smeets P , et al. Effects of hemi-portocaval shunts for inflow modulation on the outcome of small-for-size grafts in living donor liver transplantation. Am J Transplant 2005; 5 (6) 1397-1404
57 Botha JF, Campos BD, Johanning J, Mercer D, Grant W, Langnas A. Endovascular closure of a hemiportocaval shunt after small-for-size adult-to-adult left lobe living donor liver transplantation. Liver Transpl 2009; 15 (12) 1671-1675
58 Kato T, Selvaggi G, Levi D , et al. Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure: Preliminary report. Transplant Proc 2006; 38 (10) 3607-3608
59 Lee SG, Hwang S, Park KM , et al. Seventeen adult-to-adult living donor liver transplantations using dual grafts. Transplant Proc 2001; 33 (7-8) 3461-3463
60 Yang CH, Chen CL, Wang CC , et al. Dual grafts in adult-to-adult living donor liver transplantation: a single center experience in Taiwan. Surgery 2009; 145 (2) 212-218
61 Soejima Y, Taketomi A, Ikegami T , et al. Living donor liver transplantation using dual grafts from two donors: a feasible option to overcome small-for-size graft problems?. Am J Transplant 2008; 8 (4) 887-892
62 Basaran C, Agildere AM, Donmez FY , et al. MR cholangiopancreatography with T2-weighted prospective acquisition correction turbo spin-echo sequence of the biliary anatomy of potential living liver transplant donors. AJR Am J Roentgenol 2008; 190 (6) 1527-1533
63 Sirvanci M, Duran C, Ozturk E , et al. The value of magnetic resonance cholangiography in the preoperative assessment of living liver donors. Clin Imaging 2007; 31 (6) 401-405
64 Beavers KL, Sandler RS, Shrestha R. Donor morbidity associated with right lobectomy for living donor liver transplantation to adult recipients: a systematic review. Liver Transpl 2002; 8 (2) 110-117
65 Diaz GC, Renz JF, Mudge C , et al. Donor health assessment after living-donor liver transplantation. Ann Surg 2002; 236 (1) 120-126
66 Klein AS, Messersmith EE, Ratner LE, Kochik R, Baliga PK, Ojo AO. Organ donation and utilization in the United States, 1999-2008. Am J Transplant 2010; 10 (4 Pt 2) 973-986
67 Li C, Mi K, Wen Tf , et al. Outcomes of patients with benign liver diseases undergoing living donor versus deceased donor liver transplantation. PLoS ONE 2011; 6 (11) e27366
68 McDiarmid SV. Liver transplantation. The pediatric challenge. Clin Liver Dis 2000; 4 (4) 879-927
69 Sachs DH, Sykes M, Kawai T, Cosimi AB. Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol 2011; 23 (3) 165-173
70 Miyagawa-Hayashino A, Yoshizawa A, Uchida Y , et al. Progressive graft fibrosis and donor-specific HLA antibodies in pediatric late liver allografts. Liver Transpl 2012; . [Epub ahead of print]
71 Pagliara D, Savoldo B. Cytotoxic T lymphocytes for the treatment of viral infections and posttransplant lymphoproliferative disorders in transplant recipients. Curr Opin Infect Dis 2012; 25 (4) 431-437