Surgical Stress after Open and Transumbilical Laparoscopic-Assisted Appendectomy in Children

Pietro Impellizzeri; Angela Simona; Maria Grasso; Pietro Antonuccio; Caterina Crisafi; Gianfranco Scalfari; Francesco Arena; Carmelo Salpietro; Mario Lima; Carmelo Romeo

doi:10.1055/s-0033-1333634

European Journal of Pediatric Surgery, Table of Contents

Eur J Pediatr Surg 2014; 24(02): 174-178
DOI: 10.1055/s-0033-1333634

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Surgical Stress after Open and Transumbilical Laparoscopic-Assisted Appendectomy in Children

Pietro Impellizzeri

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Angela Simona

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Maria Grasso

²Unit of Genetic and Pediatric Immunology, Department of Pediatric, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Pietro Antonuccio

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Caterina Crisafi

³Unit of Anesthesiology, University of Messina, Messina, Italy

,

Gianfranco Scalfari

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Francesco Arena

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Carmelo Salpietro

²Unit of Genetic and Pediatric Immunology, Department of Pediatric, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

,

Mario Lima

⁴Unit of Pediatric Surgery, University of Bologna, Bologna, Italy

,

Carmelo Romeo

¹Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy

› Author Affiliations

Abstract

Introduction The transumbilical laparoscopic-assisted appendectomy (TULAA) effects on the surgical stress response in children have not been studied. Our aim is to investigate the stress response in TULAA.

Methods A total of 35 children underwent the appendectomy by open approach (OA) or TULAA approach. Interleukins (ILs)-6, -18, and -10 were measured before (T0), at the beginning (T1a), and at the end of surgery (T1b) and 24 hours after (T2).

Results An increase in IL-6 levels at T1b and T2 and in IL-18 at T2 was observed after OA. A significant increase of both IL-6 and IL-18 were observed at T2 but values were less compared with OA (11.6 ± 4.4 vs. 31.9 ± 8.9 pg/mL for IL-6, p = 0.0006; 145.6 vs. 174.9 pg/mL for IL-18, p = NS).

Conclusions A significant reduction in the postoperative cytokines in TULAA group suggests that this approach causes less surgical trauma in children.

Keywords

surgical stress - cytokines - transumbilical laparoscopic-assisted appendectomy - appendectomy

Full Text

References

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