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Semin Neurol 2012; 32(05): 512-516
DOI: 10.1055/s-0033-1334470
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Miller Fisher's Syndrome

James W. Teener
1   Department of Neurology, University of Michigan Health System, Ann Arbor, Michigan
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Publication History

Publication Date:
15 May 2013 (online)

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Abstract

Miller Fisher's syndrome is a rare variant of Guillain-Barré's syndrome characterized by the acute development of ataxia, ophthalmoparesis, and areflexia. Most patients have a measureable antibody in serum directed against the GQ1b ganglioside. This antibody is also present in the serum of patients with other forms of Guillain-Barré's syndrome who have prominent ataxia or ophthalmoplegia as part of their clinical presentation. Miller Fisher's syndrome generally is self-limited and has an excellent prognosis.

Keywords

Miller Fisher's syndrome - Guillain-Barré's syndrome - Bickerstaff's brainstem encephalitis - ganglioside antibodies - GQ1b antibody - ataxia - ophthalmoparesis
 

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