Urokinase Plasminogen Activator Receptor: A Functional Integrator of Extracellular Proteolysis, Cell Adhesion, and Signal Transduction

Gian Maria Sarra Ferraris; Nicolai Sidenius

doi:10.1055/s-0033-1334485

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2013; 39(04): 347-355
DOI: 10.1055/s-0033-1334485

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Urokinase Plasminogen Activator Receptor: A Functional Integrator of Extracellular Proteolysis, Cell Adhesion, and Signal Transduction

Gian Maria Sarra Ferraris

¹Cell Matrix Signaling Unit, IFOM the FIRC Institute of Molecular Oncology, Milan, Italy

,

Nicolai Sidenius

¹Cell Matrix Signaling Unit, IFOM the FIRC Institute of Molecular Oncology, Milan, Italy

› Author Affiliations

Abstract

The urokinase plasminogen activator receptor (uPAR) is a cell surface receptor involved in a multitude of physiologic and pathologic processes. uPAR regulates simultaneously a branch of the plasminogen activator system and modulates cell adhesion and intracellular signaling by interacting with extracellular matrix components and signaling receptors. The multiple uPAR functions are deeply interconnected, and their integration determines the effects that uPAR expression triggers in different contexts. The proteolytic function of uPAR affects both the signaling and the adhesive functions of the receptor, whereas these latter two are closely interconnected. This review focuses on the molecular mechanisms that connect and mutually regulate the different uPAR functions.

Keywords

proteolysis - adhesion - signaling - uPAR - vitronectin

Full Text

References

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