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Synthesis 2013; 45(11): 1546-1552
DOI: 10.1055/s-0033-1338441
DOI: 10.1055/s-0033-1338441
paper
A Green Synthesis of Quinoxalines and 2,3-Dihydropyrazines
Further Information
Publication History
Received: 24 January 2013
Accepted after revision: 02 April 2013
Publication Date:
08 May 2013 (online)
Abstract
Quinoxaline and dihydropyrazine derivatives were obtained in high yields by simple addition of 1,2-diamines and 1,2-dicarbonyl compounds in water. In some cases, the products spontaneously precipitated from the reaction mixture, making it possible to recover and reuse the mother liquor for further condensations. The very mild reaction conditions, the high yields of the products, and the absence of any catalyst make this methodology an efficient and green route to quinoxalines and dihydropyrazines.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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