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Synthesis 2013; 45(11): 1519-1523
DOI: 10.1055/s-0033-1338469
DOI: 10.1055/s-0033-1338469
paper
Cleavage of 4,6-O-Benzylidene Acetal Using Sodium Hydrogen Sulfate Monohydrate
Further Information
Publication History
Received: 04 March 2013
Accepted after revision: 29 March 2013
Publication Date:
24 April 2013 (online)
Abstract
The use of protecting groups is an important protocol in carbohydrate synthesis. Among protecting groups, benzylidene acetals are generally more stable than other acetals; therefore, strong conditions are often required for deprotection. We report the deprotection of 4,6-O-benzylidene derivatives using sodium hydrogen sulfate monohydrate under mild conditions.
Supporting Information
- for this article is available online at http://www.thieme-connect.de/ejournals/toc/synthesis. Included are 1H and 13C NMR spectra for compounds 1b–9b.
- Supporting Information
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