Synthetic Studies towards an Advanced Precursor of the Jatrophane Diterpene Pl-4

Abstract

Jatrophane diterpenes, isolated from members of the Euphorbiaceae­ plant family, constitute a class of biologically and structurally intriguing natural products. Herein, different strategies for the preparation of an advanced intermediate towards the total synthesis of the jatrophane diterpene Pl-4 are described. Key strategies for the elaboration of the jatrophane precursors include hydrometalation and radical reactions.

Key words

Euphorbiaceae - jatrophane diterpene - hydrometalation - samarium diiodide - Reformatsky reaction

• References

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