Synthetic Studies towards an Advanced Precursor of the Jatrophane Diterpene Pl-4

Rita Fürst; Christoph Lentsch; Uwe Rinner

doi:10.1055/s-0033-1338565

Synthesis, Table of Contents

Synthesis 2014; 46(03): 357-367
DOI: 10.1055/s-0033-1338565

paper

Synthetic Studies towards an Advanced Precursor of the Jatrophane Diterpene Pl-4

Authors

Rita Fürst

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria Fax: +43(1)427752101 Email: uwe.rinner@univie.ac.at
Christoph Lentsch

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria Fax: +43(1)427752101 Email: uwe.rinner@univie.ac.at
Uwe Rinner*

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria Fax: +43(1)427752101 Email: uwe.rinner@univie.ac.at

Abstract

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Abstract

Jatrophane diterpenes, isolated from members of the Euphorbiaceae plant family, constitute a class of biologically and structurally intriguing natural products. Herein, different strategies for the preparation of an advanced intermediate towards the total synthesis of the jatrophane diterpene Pl-4 are described. Key strategies for the elaboration of the jatrophane precursors include hydrometalation and radical reactions.

Key words

Euphorbiaceae - jatrophane diterpene - hydrometalation - samarium diiodide - Reformatsky reaction

Full Text

References

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Supplementary Material

Supporting Information (PDF)