Download PDF
Synthesis 2014; 46(05): 607-612
DOI: 10.1055/s-0033-1338578
paper
© Georg Thieme Verlag Stuttgart · New York

Copper/Silver-Mediated Decarboxylative Trifluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na

Jun Yin
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China   Fax: +86(411)84986295   Email: ymli@dlut.edu.cn
,
Yaming Li*
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China   Fax: +86(411)84986295   Email: ymli@dlut.edu.cn
,
Rong Zhang
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China   Fax: +86(411)84986295   Email: ymli@dlut.edu.cn
,
Kun Jin
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China   Fax: +86(411)84986295   Email: ymli@dlut.edu.cn
,
Chunying Duan*
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China   Fax: +86(411)84986295   Email: ymli@dlut.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 18 August 2013

Accepted after revision: 29 November 2013

Publication Date:
17 December 2013 (online)

   Buy Article Permissions and Reprints All articles of this category


Zoom Image

Abstract

A copper/silver-catalyzed decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na was performed under relatively mild conditions. The reaction shows high E/Z selectivity and wide substrate tolerance. Ag2CO3 plays an important role in promoting the decarboxylation process.

Key words

fluorine - transition metals - copper - catalysis - radicals

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
  • Supporting Information