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Synthesis 2014; 46(15): 2045-2050
DOI: 10.1055/s-0033-1338628
DOI: 10.1055/s-0033-1338628
paper
Direct Access to Isoindolinone Derivatives by Palladium-Catalyzed C–H Activation and Isocyanide Insertion by Using Molecular Oxygen as the Sole Oxidant
Further Information
Publication History
Received: 13 January 2014
Accepted after revision: 04 April 2014
Publication Date:
20 May 2014 (online)
Abstract
We report a straightforward, aerobic, palladium-catalyzed C–H activation, followed by isocyanide insertion to synthesize isoindolinone derivatives. This transformation is an efficient and step-economic strategy using oxygen as the sole oxidant. We anticipate that this work will inspire in-depth studies as well as versatile applications in various related fields.
Key words
palladium-catalyzed - C–H activation - isocyanide insertion - isoindolinone - oxygen - heterocyclesSupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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References
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