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Synthesis 2014; 46(14): 1859-1870
DOI: 10.1055/s-0033-1338637
DOI: 10.1055/s-0033-1338637
special topic
Copper-Mediated Direct Functionalization of Unsaturated C–C Bonds with Ethyl Bromo(difluoro)acetate: A Straightforward Access to Highly Valuable Difluoromethylated Alkenes
Further Information
Publication History
Received: 27 February 2014
Accepted after revision: 13 April 2014
Publication Date:
28 May 2014 (online)
Abstract
A copper-mediated fluorofunctionalization of alkenes and alkynes has been developed. This method provides ready access to trisubstituted difluoromethylated olefins (from dihydropyrans, glycal derivatives, or terminal alkynes) or to tetrasubstituted olefins (from disubstituted alkynes). The products were obtained in good to high yields with acceptable E/Z selectivities. Finally, a first direct route to difluoromethylated alkynes is reported, albeit with low yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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References
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For selected examples, see:
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