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Synlett 2013; 24(13): 1657-1662
DOI: 10.1055/s-0033-1339298
DOI: 10.1055/s-0033-1339298
letter
Tandem Hydroformylation–Biginelli Reaction
Further Information
Publication History
Received: 24 April 2013
Accepted after revision: 29 May 2013
Publication Date:
12 July 2013 (online)
![](https://www.thieme-connect.de/media/synlett/201313/lookinside/thumbnails/10.1055-s-0033-1339298-1.jpg)
Abstract
The combination of a tandem process with a multicomponent reaction is a new approach to high atom-economic synthesis. A tandem hydroformylation–Biginelli reaction sequence has been developed leading to a variety of functionalized 4-alkyl-substituted 3,4-dihydropyrimidin-2(1H)-ones.
Key words
hydroformylation - Biginelli reaction - tandem reaction - multicomponent reaction - rhodiumSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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