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Synthesis 2013; 45(19): 2763-2767
DOI: 10.1055/s-0033-1339492
DOI: 10.1055/s-0033-1339492
paper
Medium Buffer Effects on the Condensation of l-Cysteine and Aryl Nitriles to (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acids
Further Information
Publication History
Received: 02 July 2013
Accepted after revision: 11 July 2013
Publication Date:
24 July 2013 (online)
Abstract
The condensation of l-cysteine and aryl nitriles to (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acids in buffered media was reinvestigated. Pure products (yields of 58–95%; up to 99% ee) were obtained in a NaHCO3/NaOH-buffered aqueous alcoholic medium.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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