Search for Ideal P-Chiral Phosphorus Ligands for Practical Asymmetric 
Hydrogenation and Asymmetric Suzuki–Miyaura Coupling

Guodu Liu; Guangqing Xu; Renshi Luo; Wenjun Tang

doi:10.1055/s-0033-1339875

Synlett, Inhaltsverzeichnis

Synlett 2013; 24(19): 2465-2471
DOI: 10.1055/s-0033-1339875

synpacts

Search for Ideal P-Chiral Phosphorus Ligands for Practical Asymmetric Hydrogenation and Asymmetric Suzuki–Miyaura Coupling

Guodu Liu

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China Fax: +86(21)54925515 eMail: tangwenjun@sioc.ac.cn

,

Guangqing Xu

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China Fax: +86(21)54925515 eMail: tangwenjun@sioc.ac.cn

,

Renshi Luo

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China Fax: +86(21)54925515 eMail: tangwenjun@sioc.ac.cn

,

Wenjun Tang*

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China Fax: +86(21)54925515 eMail: tangwenjun@sioc.ac.cn

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Abstract

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Abstract

The synthesis of P-chiral phosphorus ligands with novel structures is important for the development of efficient asymmetric catalytic transformations. Here, we describe the development of P-chiral phosphorus ligands such as BIBOP, WingPhos, BI-DIME, and 8 in our laboratory. Conformational rigidity, high tunability of electronic and steric properties, and convenient physical properties are the main features of our ligand design. Progress in developing practical asymmetric hydrogenation and asymmetric cross-coupling reactions are discussed.

Key words

P-chiral phosphorus ligands - asymmetric catalysis - hydrogenation - cross-coupling

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Referenzen

References and Notes

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