Synthesis of N-Sulfonylamidines by Catalyst-Free Hydroamination of Ynamides and Amines

Abstract

A novel synthesis of N-sulfonylamidines by catalyst-free hydroamination of N,N-disulfonyl ynamides with amines was developed. Alkyl amines react with N,N-disulfonyl ynamides under mild conditions, whereas aryl amines require higher temperatures. Plausible mechanisms are proposed to explain this reaction.

Key words

amines - sulfonamides - aminations

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