Synthesis of N-Sulfonylamidines by Catalyst-Free Hydroamination of Ynamides and Amines

Yulong Kong; Lian Yu; Yuming Cui; Jian Cao

doi:10.1055/s-0033-1340287

Synthesis, Table of Contents

Synthesis 2014; 46(02): 183-188
DOI: 10.1055/s-0033-1340287

paper

Synthesis of N-Sulfonylamidines by Catalyst-Free Hydroamination of Ynamides and Amines

Yulong Kong

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Wenyi Road 222, Hangzhou 310012, P. R. of China Fax: +86(571)28865135 Email: caojian@hznu.edu.cn

,

Lian Yu

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Wenyi Road 222, Hangzhou 310012, P. R. of China Fax: +86(571)28865135 Email: caojian@hznu.edu.cn

,

Yuming Cui

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Wenyi Road 222, Hangzhou 310012, P. R. of China Fax: +86(571)28865135 Email: caojian@hznu.edu.cn

,

Jian Cao*

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Wenyi Road 222, Hangzhou 310012, P. R. of China Fax: +86(571)28865135 Email: caojian@hznu.edu.cn

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Abstract

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Abstract

A novel synthesis of N-sulfonylamidines by catalyst-free hydroamination of N,N-disulfonyl ynamides with amines was developed. Alkyl amines react with N,N-disulfonyl ynamides under mild conditions, whereas aryl amines require higher temperatures. Plausible mechanisms are proposed to explain this reaction.

Key words

amines - sulfonamides - aminations

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References

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