Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin

Abstract

The first enantioselective catalytic total synthesis of (–)-pyridovericin is reported. The key steps involve a modified HWE reaction under aqueous conditions and an asymmetric iridium-catalyzed hydrogenation. This resulted in a highly modular and stereoselective approach that delivered the target natural product in high yield and stereoselectivity.

Key words

pyridovericin - total synthesis - natural products - hydrogenation - asymmetric catalysis

• References

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