Highly Diastereoselective Synthesis of Cyclopentenones via a One-Pot Gold Catalysis, Nazarov Cyclization and Alkylation Cascade

Abstract

Starting from readily available propargylic carboxylates, three sequential transformations [gold-catalyzed tandem reaction, scandium(III) trifluoromethanesulfonate catalyzed Nazarov cyclization, alkylation reaction] in a one-pot process led to the formation of cyclopentenone derivatives in excellent diastereoselectivities and moderate to good overall yields.

Key words

gold catalysis - Nazarov cyclization - alkylation reaction - one-pot cascade - Lewis acids

• References


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