Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Moran Amit; Yoav Binenbaum; Kanika Sharma; Ramer Naomi; Ramer Ilana; Agbetoba Abib; Brett Miles; Xinjie Yang; Delin Lei; Bjoerndal Kristine; Godballe Christian; Mücke Thomas; Wolff Klaus-Dietrich; Dan Fliss; André M. Eckardt; Copelli Chiara; Enrico Sesenna; Palmer Frank; Snehal Patel; Ziv Gil

doi:10.1055/s-0033-1347358

Journal of Neurological Surgery Part B: Skull Base, Table of Contents

J Neurol Surg B Skull Base 2013; 74(03): 118-125
DOI: 10.1055/s-0033-1347358

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Moran Amit

¹Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel

,

Yoav Binenbaum

¹Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel

,

Kanika Sharma

²Department of Radiotherapy & Oncology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India

,

Ramer Naomi

³Department of Pathology, Mount Sinai Medical Center, New York, New York, USA

,

Ramer Ilana

³Department of Pathology, Mount Sinai Medical Center, New York, New York, USA

,

Agbetoba Abib

⁴Department of Otolaryngology, The Mount Sinai School of Medicine, New York, New York, USA

,

Brett Miles

⁴Department of Otolaryngology, The Mount Sinai School of Medicine, New York, New York, USA

,

Xinjie Yang

⁵Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, P. R. China

,

Delin Lei

⁵Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, P. R. China

,

Bjoerndal Kristine

⁶Department of Otolaryngology Head and Neck Surgery, Odense University Hospital, Odense, Denmark

,

Godballe Christian

⁶Department of Otolaryngology Head and Neck Surgery, Odense University Hospital, Odense, Denmark

,

Mücke Thomas

⁷Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universität München, München, Germany

,

Wolff Klaus-Dietrich

⁷Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universität München, München, Germany

,

Dan Fliss

⁸Department of Otolaryngology Head and Neck Surgery, Tel Aviv Medical Center, Tel Aviv, Israel

,

André M. Eckardt

⁹Department of Cranio-Maxillofacial Surgery, Hannover Medical School, Hannover, Germany

,

Copelli Chiara

¹⁰Maxillo-Facial Surgery, University-Hospital of Parma, Parma, Italy

,

Enrico Sesenna

¹⁰Maxillo-Facial Surgery, University-Hospital of Parma, Parma, Italy

,

Palmer Frank

¹¹Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

,

Snehal Patel

¹¹Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

,

Ziv Gil

¹Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel

› Author Affiliations

Abstract

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base.

Design Meta-analysis of the literature and data from the International ACC Study Group.

Setting University-affiliated medical center.

Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months).

Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS).

Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis.

Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

Keywords

adenoid cystic carcinoma - paranasal sinuses - skull base - meta analysis - survival

Full Text

References

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