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Am J Perinatol 2014; 31(04): 279-286
DOI: 10.1055/s-0033-1347362
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Risk Factors Associated with Nephrocalcinosis in Preterm Infants

Hyun Seung Lee
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
In Kyung Sung
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Soon Ju Kim
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Young Ah Youn
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Ju Young Lee
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Gye-Yeon Lim
2   Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Soo Ah Im
2   Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Young Mi Ku
2   Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
Jung Hyun Lee
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
,
So Young Kim
1   Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
› Author Affiliations
Further Information

Publication History

13 November 2012

21 April 2013

Publication Date:
03 June 2013 (online)

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Abstract

Purpose The objective was to identify the risk factors associated with nephrocalcinosis (NC) in preterm infants.

Methods NC was diagnosed by renal sonography at 4 or 8 weeks of life, and 10 infants who had findings of type 3 or 4 NC were classified as the NC group. Various clinical and laboratory factors were compared between NC and control groups.

Results Serum sodium (Na) on day 1, serum creatinine and fractional excretion of calcium (FeCa) at 1 and 2 weeks, and serum calcium (Ca), fractional excretion of sodium (FeNa), and urine Na on 2 weeks of life were significantly different between the two groups: the NC group showed significantly higher serum creatinine, FeNa, and FeCa than the control group, suggesting a greater decrease in renal function in the NC group. Differences of the laboratory findings disappeared after 4 weeks of life. The strongest risk factor was birth weight.

Conclusion A transient decrease in renal function during the first 2 weeks of life was associated with development of NC in preterm very low-birth-weight infants, and the risk of NC increased as birth weight decreased.

Keywords

nephrocalcinosis - preterm - very low birth weight - immaturity
 

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