PDF icon PDF herunterladen
J Neurol Surg B Skull Base 2013; 74(05): 292-299
DOI: 10.1055/s-0033-1348027
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Metastatic Disease to the Clivus Mimicking Clival Chordomas

Adam S. DeConde
1   Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Yas Sanaiha
1   Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Jeffrey D. Suh
1   Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Sunita Bhuta
2   Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Marvin Bergsneider
3   Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
,
Marilene B. Wang
1   Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
› Institutsangaben
Weitere Informationen

Publikationsverlauf

21. Februar 2013

15. April 2013

Publikationsdatum:
26. Juni 2013 (online)

Auch verfügbar aufMedOne
   Lizenzen und Reprints
Preview

Abstract

Objectives/Hypothesis A comprehensive review of the literature of clival metastases and presentation of two additional cases.

Study Design Literature review and report of two cases.

Methods A literature review of the MEDLINE database (1950 to January 19, 2013) was performed to identify all cases of patients with metastatic disease to the clivus. Additionally, two novel cases are presented.

Results In total, 47 cases were identified in the literature, including the two cases presented in this study. Metastatic disease to the clivus is the initial presenting symptom of the primary malignancy in 36% (13/36) of the cases. When there was a history of malignancy, the median interval of time to clival metastases was 24 months (range 1 to 172 months). Clinical symptoms manifested often as cranial neuropathies, with at least abducens palsies as the initial presenting symptom in 61.9% (26/42) of patients. Tumor pathology was diverse, but several pathologies were seen more commonly: prostate carcinoma (18.1%, 9/47), hepatocellular carcinoma (10.6%, 5/47), and thyroid follicular carcinoma (8.5%, 4/47).

Conclusion Although clival metastases are extremely rare, they are an important part of the differential of clival masses as they can be the presenting symptom of distant malignancy.

Level of Evidence 4.

Keywords

skull base - clivus - clival metastases - clival tumor - clival chordoma

Note

This study was presented as a poster presentation at the North American Skull Base Society Annual Meeting, February 17 to 19, 2012, Las Vegas, NV.