Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000072.xml
Semin Reprod Med 2013; 31(05): 340-346
DOI: 10.1055/s-0033-1348892
DOI: 10.1055/s-0033-1348892
Disparities in Obstetrical Outcomes in ART Pregnancies Compared with Natural Conceptions
Further Information
Publication History
Publication Date:
09 August 2013 (online)
Abstract
Health disparities are observed in all fields of medicine and reproductive health is not immune to this phenomenon. The incidence of women using infertility treatments to conceive is increasing. Women undergoing assisted reproduction appear to be at increased risk of adverse outcomes, and minority women tend to be at even greater risk. This article examines several adverse obstetrical outcomes including preterm birth, congenital malformations, and preeclampsia among women receiving infertility treatments compared with those who conceive spontaneously. It will further examine societal costs associated with these procedures.
-
References
- 1 Bryant AS, Worjoloh A, Caughey AB, Washington AE. Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants. Am J Obstet Gynecol 2010; 202 (4) 335-343
- 2 Bell JF, Zimmerman FJ, Almgren GR, Mayer JD, Huebner CE. Birth outcomes among urban African-American women: a multilevel analysis of the role of racial residential segregation. Soc Sci Med 2006; 63 (12) 3030-3045
- 3 Kramer MR, Hogue CR. Place matters: variation in the black/white very preterm birth rate across U.S. metropolitan areas, 2002-2004. Public Health Rep 2008; 123 (5) 576-585
- 4 Messer LC, Vinikoor LC, Laraia BA , et al. Socioeconomic domains and associations with preterm birth. Soc Sci Med 2008; 67 (8) 1247-1257
- 5 Masi CM, Hawkley LC, Piotrowski ZH, Pickett KE. Neighborhood economic disadvantage, violent crime, group density, and pregnancy outcomes in a diverse, urban population. Soc Sci Med 2007; 65 (12) 2440-2457
- 6 Reagan PB, Salsberry PJ. Race and ethnic differences in determinants of preterm birth in the USA: broadening the social context. Soc Sci Med 2005; 60 (10) 2217-2228
- 7 Savitz DA, Kaufman JS, Dole N, Siega-Riz AM, Thorp Jr JM, Kaczor DT. Poverty, education, race, and pregnancy outcome. Ethn Dis 2004; 14 (3) 322-329
- 8 Lu MC, Chen B. Racial and ethnic disparities in preterm birth: the role of stressful life events. Am J Obstet Gynecol 2004; 191 (3) 691-699
- 9 Armstrong A, Plowden TC. Ethnicity and assisted reproductive technologies. Clin Pract (Lond) 2012; 9 (6) 651-658
- 10 Seifer DB, Frazier LM, Grainger DA. Disparity in assisted reproductive technologies outcomes in black women compared with white women. Fertil Steril 2008; 90 (5) 1701-1710
- 11 Feinberg EC, Larsen FW, Catherino WH, Zhang J, Armstrong AY. Comparison of assisted reproductive technology utilization and outcomes between Caucasian and African American patients in an equal-access-to-care setting. Fertil Steril 2006; 85 (4) 888-894
- 12 Sharara FI, McClamrock HD. Differences in in vitro fertilization (IVF) outcome between white and black women in an inner-city, university-based IVF program. Fertil Steril 2000; 73 (6) 1170-1173
- 13 McCarthy-Keith DM, Schisterman EF, Robinson RD, O'Leary K, Lucidi RS, Armstrong AY. Will decreasing assisted reproduction technology costs improve utilization and outcomes among minority women?. Fertil Steril 2010; 94 (7) 2587-2589
- 14 Lamb JD, Huddleston HG, Purcell KJ , et al. Asian ethnicity is associated with decreased pregnancy rates following intrauterine insemination. Reprod Biomed Online 2009; 19 (2) 252-256
- 15 Purcell K, Schembri M, Frazier LM , et al. Asian ethnicity is associated with reduced pregnancy outcomes after assisted reproductive technology. Fertil Steril 2007; 87 (2) 297-302
- 16 Langen ES, Shahine LK, Lamb JD , et al. Asian ethnicity and poor outcomes after in vitro fertilization blastocyst transfer. Obstet Gynecol 2010; 115 (3) 591-596
- 17 Shahine LK, Lamb JD, Lathi RB, Milki AA, Langen E, Westphal LM. Poor prognosis with in vitro fertilization in Indian women compared to Caucasian women despite similar embryo quality. PLoS ONE 2009; 4 (10) e7599
- 18 Fujimoto VY, Luke B, Brown MB , et al; Society for Assisted Reproductive Technology Writing Group. Racial and ethnic disparities in assisted reproductive technology outcomes in the United States. Fertil Steril 2010; 93 (2) 382-390
- 19 Finn H. The baby chase. Wall Street Journal Online. July 23, 2011. http://online.wsj.com/article/SB10001424053111903461104576458134196248312.html
- 20 Centers for Disease Control and Prevention. American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. Assisted Reproductive Technology Success Rates: National Summary and Fertility Clinic Reports. Atlanta, GA: United States Department of Health and Human Services; 2010
- 21 Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update 2012; 18 (5) 485-503
- 22 Schieve LA, Ferre C, Peterson HB, Macaluso M, Reynolds MA, Wright VC. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol 2004; 103 (6) 1144-1153
- 23 Wisborg K, Ingerslev HJ, Henriksen TB. In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study. Fertil Steril 2010; 94 (6) 2102-2106
- 24 D'Angelo DV, Whitehead N, Helms K, Barfield W, Ahluwalia IB. Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment. Fertil Steril 2011; 96 (2) 314-320 , e2
- 25 Hayashi M, Nakai A, Satoh S, Matsuda Y. Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used. Fertil Steril 2012; 98 (4) 922-928
- 26 Camarano L, Alkon A, Nachtigall RD, Schembri M, Weiss S, Croughan MS. Preterm delivery and low birth weight in singleton pregnancies conceived by women with and without a history of infertility. Fertil Steril 2012; 98 (3) 681-686 , e1
- 27 Jaques AM, Amor DJ, Baker HW , et al. Adverse obstetric and perinatal outcomes in subfertile women conceiving without assisted reproductive technologies. Fertil Steril 2010; 94 (7) 2674-2679
- 28 Raatikainen K, Kuivasaari-Pirinen P, Hippeläinen M, Heinonen S. Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies. Hum Reprod 2012; 27 (4) 1162-1169
- 29 Picaud JC, Chalies S, Combes C, Mercier G, Dechaud H, Cambonie G. Neonatal mortality and morbidity in preterm infants born from assisted reproductive technologies. Acta Paediatr 2012; 101 (8) 846-851
- 30 Wen J, Jiang J, Ding C , et al. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil Steril 2012; 97 (6) 1331-1337 , e1–e4
- 31 Davies MJ, Moore VM, Willson KJ , et al. Reproductive technologies and the risk of birth defects. N Engl J Med 2012; 366 (19) 1803-1813
- 32 Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 2002; 346 (10) 725-730
- 33 Zhu JL, Hvidtjørn D, Basso O , et al. Parental infertility and cerebral palsy in children. Hum Reprod 2010; 25 (12) 3142-3145
- 34 Reddy UM, Wapner RJ, Rebar RW, Tasca RJ. Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol 2007; 109 (4) 967-977
- 35 Shevell T, Malone FD, Vidaver J , et al. Assisted reproductive technology and pregnancy outcome. Obstet Gynecol 2005; 106 (5, Pt 1) 1039-1045
- 36 American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Obstetrics; Society for Maternal-Fetal Medicine; ACOG Joint Editorial Committee. ACOG practice bulletin #56: Multiple gestation: complicated twin, triplet, and high-order multifetal pregnancy. Obstet Gynecol 2004; 104 (4) 869-883
- 37 Practice Committee of American Society for Reproductive Medicine. Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine Practice Committee opinion. Fertil Steril 2012; 97 (4) 825-834
- 38 Hvidtjørn D, Grove J, Schendel D , et al. Multiplicity and early gestational age contribute to an increased risk of cerebral palsy from assisted conception: a population-based cohort study. Hum Reprod 2010; 25 (8) 2115-2123
- 39 Hvidtjørn D, Schieve L, Schendel D, Jacobsson B, Svaerke C, Thorsen P. Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: a systematic review and meta-analysis. Arch Pediatr Adolesc Med 2009; 163 (1) 72-83
- 40 Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003; 102 (1) 181-192
- 41 Tan SL, Doyle P, Campbell S , et al. Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies. Am J Obstet Gynecol 1992; 167 (3) 778-784
- 42 Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008; 51 (4) 970-975
- 43 Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004; 103 (3) 551-563
- 44 Wang JX, Knottnerus AM, Schuit G, Norman RJ, Chan A, Dekker GA. Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia. Lancet 2002; 359 (9307) 673-674
- 45 Einarsson JI, Sangi-Haghpeykar H, Gardner MO. Sperm exposure and development of preeclampsia. Am J Obstet Gynecol 2003; 188 (5) 1241-1243
- 46 Smith GN, Walker M, Tessier JL, Millar KG. Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol 1997; 177 (2) 455-458
- 47 Klatsky PC, Delaney SS, Caughey AB, Tran ND, Schattman GL, Rosenwaks Z. The role of embryonic origin in preeclampsia: a comparison of autologous in vitro fertilization and ovum donor pregnancies. Obstet Gynecol 2010; 116 (6) 1387-1392
- 48 Skora D, Frankfurter D. Adverse perinatal events associated with ART. Semin Reprod Med 2012; 30 (2) 84-91
- 49 Allen VM, Wilson RD, Cheung A. Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC) Reproductive Endocrinology Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC). Pregnancy outcomes after assisted reproductive technology. J Obstet Gynaecol Can 2006; 28 (3) 220-250
- 50 Cox GF, Bürger JB, Lip V , et al. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet 2002; 71 (1) 162-164
- 51 Ørstavik KH, Eiklid K, van der Hagen CB , et al. Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection. Am J Hum Genet 2003; 72 (1) 218-219
- 52 Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Racial and ethnic disparities in assisted reproductive technology pregnancy and live birth rates within body mass index categories. Fertil Steril 2011; 95 (5) 1661-1666
- 53 McClamrock HD. The great weight debate: do elevations in body mass index (BMI) exert a negative extraovarian effect on in vitro fertilization outcome?. Fertil Steril 2008; 89 (6) 1609-1610
- 54 Dessolle L, Daraï E, Cornet D , et al. Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers. Hum Reprod 2009; 24 (12) 3082-3089
- 55 Tepper NK, Farr SL, Cohen BB , et al. Singleton preterm birth: risk factors and association with assisted reproductive technology. Matern Child Health J 2012; 16 (4) 807-813
- 56 Chung K, Coutifaris C, Chalian R , et al. Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril 2006; 86 (6) 1634-1641
- 57 Sazonova A, Källen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod 2012; 27 (5) 1343-1350
- 58 Joshi N, Kissin D, Anderson JE, Session D, Macaluso M, Jamieson DJ. Trends and correlates of good perinatal outcomes in assisted reproductive technology. Obstet Gynecol 2012; 120 (4) 843-851
- 59 Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol 2011; 23 (3) 168-173
- 60 Petrou S, Eddama O, Mangham L. A structured review of the recent literature on the economic consequences of preterm birth. Arch Dis Child Fetal Neonatal Ed 2011; 96 (3) F225-F232
- 61 Institute of Medicine. . Preterm Birth: Causes, Consequences and Prevention. Washington, DC: The National Academies Press; 2007