Idiopathisches Parkinson-Syndrom und Melanom: erhöhte Koinzidenz und Zusammenhang mit L-Dopa?

S. Michelmann; I. Moll; C. Buhmann; M. O. Koch; U. Hauswirth

doi:10.1055/s-0033-1349100

Aktuelle Neurologie, Table of Contents

Aktuelle Neurologie 2013; 40(06): 309-314
DOI: 10.1055/s-0033-1349100

Originalarbeit

Idiopathisches Parkinson-Syndrom und Melanom: erhöhte Koinzidenz und Zusammenhang mit L-Dopa?

Parkinson’s Disease and Melanoma: Is There an Increased Incidence of their Joint Occurrence under L-Dopa Therapy?

S. Michelmann

¹Klinik und Poliklinik für Dermatologie und Venerologie Universitätsklinikums Hamburg-Eppendorf

,

I. Moll

¹Klinik und Poliklinik für Dermatologie und Venerologie Universitätsklinikums Hamburg-Eppendorf

,

C. Buhmann

²Ambulanzzentrum - Bereich Neurologie, Universitätsklinikum Hamburg-Eppendorf

,

M. O. Koch

³Neurologie Toggenburg, Wattwil/Schweiz

,

U. Hauswirth

⁴Dermatologie Toggenburg, Wattwil/Schweiz

› Author Affiliations

Abstract

Zusammenfassung

Der Zusammenhang zwischen Idiopathischen Parkinson-Syndrom (IPS), L-Dopa-Therapie und malignem Melanom wirft weiterhin Fragen auf. Aus diesem Grund wurde von uns eine Studie mit 712 Parkinson-Patienten aus der Klinik und Poliklinik für Neurologie des Universitätsklinikum Hamburg-Eppendorf durchgeführt, die einerseits zeigte, dass IPS-Patienten formal statistisch ein 1-bis zu 4-fach erhöhtes Melanomrisiko haben und andererseits, dass eine L-Dopa-Therapie die Entstehung eines Melanoms nicht ursächlich zu fördern scheint.

Abstract

The relationship between Parkinson's disease (PD), L-dopa therapy and melanoma is still a topic of some controversy. For this reason we have conducted a study with 712 PD patients of the Department of Neurology in the University Hospital Hamburg-Eppendorf. It showed, on the one hand, that PD patients have statistically a 4-times increased risk to develop a melanoma while, on the other hand, that an L-dopa therapy does not promote the development of melanoma.

Schlüsselwörter

IPS und Melanom - IPS - Melanom - L-Dopa

Keywords

Parkinson’s disease and melanoma - Parkinson’s disease - melanoma - L-dopa

Full Text

References

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