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Eur J Pediatr Surg 2013; 23(05): 375-382
DOI: 10.1055/s-0033-1352529
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Tissue Engineering of Skin for Wound Coverage

Thomas Biedermann
1   Department of Surgery, Tissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland
,
Sophie Boettcher-Haberzeth
1   Department of Surgery, Tissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland
2   Pediatric Burn Center, Department of Plastic and Reconstructive Surgery, University Children's Hospital Zurich, Zurich, Switzerland
,
Ernst Reichmann
1   Department of Surgery, Tissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland
› Author Affiliations
Further Information

Publication History

01 July 2013

02 July 2013

Publication Date:
27 August 2013 (online)

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Abstract

Over the past few decades, important milestones have been reached in the field of skin tissue engineering, bringing the ultimate goal of fabricating an autologous dermoepidermal skin substitute with all its cellular components and skin appendages closer to reality. Yet, scientific progress alone is not enough, clinical demands must be addressed and commercial interests need to be fulfilled. This review gives an overview of commercially available skin substitutes for skin replacement therapies and an insight into the recent development of an autologous full-thickness skin substitute that can readily be transplanted in large quantities onto the patient.

Keywords

skin tissue engineering - skin substitute - dermal substitute - burn wound - chronic wound
 

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