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Neuropediatrics 2013; 44(06): 297-301
DOI: 10.1055/s-0033-1358602
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Role of Autoantibodies in Acquired Inflammatory Demyelinating Diseases of the Central Nervous System in Children

Kevin Rostasy
1   Division of Pediatric Neurology, Department of Pediatrics I, Innsbruck Medical University, Innsbruck, Austria
,
Markus Reindl
2   Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
› Author Affiliations
Further Information

Publication History

17 July 2013

05 August 2013

Publication Date:
28 October 2013 (online)

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Abstract

The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell–dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.

Keywords

children - anti-MOG antibodies - MS - ADEM
 

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