Percentage of Circulating CD8+ T Lymphocytes is Associated with Albuminuria in Type 2 Diabetes Mellitus

L. Lei; Y. Mao; D. Meng; X. Zhang; L. Cui; Y. Huo; Y. Wang

doi:10.1055/s-0033-1358666

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2014; 122(1): 27-30
DOI: 10.1055/s-0033-1358666

Article

Percentage of Circulating CD8+ T Lymphocytes is Associated with Albuminuria in Type 2 Diabetes Mellitus

L. Lei

¹Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China

,

Y. Mao

²Department of Cardiology, Peking University First Hospital, Beijing, China

³Department of Biochemistry, National Cerebral and Cardiovascular Center, Osaka, Japan

,

D. Meng

¹Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China

,

X. Zhang

¹Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China

,

L. Cui

¹Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China

,

Y. Huo

²Department of Cardiology, Peking University First Hospital, Beijing, China

,

Y. Wang

¹Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, Beijing, China

› Author Affiliations

Abstract

T lymphocytes have been demonstrated to play a role in the development of diabetic proteinuria. However, the alteration of circulating T lymphocytes has not been investigated in a type 2 diabetic cohort. A cross-sectional study was conducted in Peking University Aerospace Center Hospital. 510 participants were type 2 diabetes mellitus, 30–70 years of age. Patients with immune disease, medical conditions that affect immune function, infection, or end-organ damage were excluded. The percentage of circulating CD8+ T lymphocytes was significantly associated with albuminuria in the cohort. The impact of albuminuria to CD8+ T lymphocytes in a multivariate linear regression model was indicated by the B- coefficient (95% confidence interval) 1.812 (0.204–3.421, P=0.03). Our data first showed that the percentage of circulating CD8+ T cells is associated with albuminuria in type 2 diabetes mellitus, which may support the rationality of systemic inhibition of T lymphocytes in treating albuminuria in these patients.

Key words

T lymphocytes - type 2 diabetes mellitus - albuminuria - CD8

Full Text

References

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