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Aktuelle Neurologie 2014; 41(01): 40-42
DOI: 10.1055/s-0033-1359972
DOI: 10.1055/s-0033-1359972
Debatte: Pro & Kontra
Interventionelle Therapie von symptomatischen intrakraniellen Gefäßstenosen – Pro
Interventional Therapy of Symptomatic Intracranial Stenoses – ProFurther Information
Publication History
Publication Date:
12 February 2014 (online)

Pro
Grundsätzliche Überlegungen
In der SAMMPRIS-Studie zeigte sich eine deutlich höhere Komplikationsrate im Behandlungsarm „intrakranielles Stenting“ in Kombination mit „aggressivem medikamentösem Management“ gegenüber dem „aggressiven medikamentösen Management“ allein (14,7 vs. 5,8 % Schlaganfall oder Tod nach 30 Tagen; p = 0,002) [1]. Auch nach einem Jahr war der endovaskuläre Behandlungsarm noch signifikant unterlegen (20 vs. 12,2 %; p = 0,009). Es handelt sich hier um eine Studie zur Sekundärprophylaxe beim Schlaganfall.
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Literatur
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- 2 Derdeyn CP, Chimowitz MI, Lynn MJ et al. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet 2013; (epub ahead of print)
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- 4 Bose A, Hartmann M, Henkes H et al. A novel, self-expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan study. Stroke 2007; 38: 1531-1537
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- 7 Liebeskind DS, Cotsonis GA, Saver JL et al. Collaterals dramatically alter stroke risk in intracranial atherosclerosis. Ann Neurol 2011; 69: 963-974
- 8 Kim JT, Kim HJ, Yoo SH et al. MRI findings may predict early neurologic deterioration in acute minor stroke or transient ischemic attack due to intracranial atherosclerosis. Eur Neurol 2010; 64: 95-100
- 9 Derdeyn CP, Fiorella D, Lynn MJ et al. Impact of operator and site experience on outcomes after angioplasty and stenting in the SAMMPRIS trial. J Neurointerv Surg 2013; 6: 528-533
- 10 Fiorella D, Derdeyn CP, Lynn MJ et al. Detailed analysis of periprocedural strokes in patients undergoing intracranial stenting in Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS). Stroke 2012; 43: 2682-2688