Xanthones from Swertia mussotii and Their α-Glycosidase
                    Inhibitory Activities

Cui-Ting Luo; Huan-huan Zheng; Shuang-Shuang Mao; Mao-xun Yang; Cheng Luo; Heru Chen

doi:10.1055/s-0033-1360173

Planta Medica, Table of Contents

Planta Med 2014; 80(02/03): 201-208
DOI: 10.1055/s-0033-1360173

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Xanthones from Swertia mussotii and Their α-Glycosidase Inhibitory Activities

Cui-Ting Luo

¹Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

,

Huan-huan Zheng

¹Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

,

Shuang-Shuang Mao

¹Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

,

Mao-xun Yang

¹Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

,

Cheng Luo

²State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China

,

Heru Chen

¹Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China

²State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China

³Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P. R. China

› Author Affiliations

Abstract

Two new xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known xanthones (3–28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC₅₀ value of 5.33 ± 0.09 µM, while the O-glycosylated xanthones were poor α-glycosidase inhibitors.

Key words

Gentianaceae - Swertia mussotii - xanthones - α-glucosidase inhibitor - diabetes mellitus

Full Text

References

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