kleintier konkret 2013; 16(6): 9-14
DOI: 10.1055/s-0033-1361508
hund|katze
analgesie
Enke Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart

Schmerztherapie beim Kleintier – Gibt es etwas Neues?

Sabine Tacke
Klinikum Veterinärmedizin, Klinik für Kleintiere, Chirurgie, Anästhesiologie, perioperative Intensivmedizin, Schmerztherapie, Justus-Liebig-Universität Gießen
› Author Affiliations
Further Information

Publication History

Publication Date:
09 January 2014 (online)

Die Schmerztherapie muss an den individuellen Zustand des Patienten angepasst werden, wobei Grad und Dauer der Schmerzen, aber auch der Schmerztyp zu berücksichtigen sind. Dabei ist die rasche Einleitung der Therapie empfehlenswert, um die Bildung eines Schmerzgedächtnisses und somit die Chronifizierung zu verhindern. Im Folgenden werden die in den letzten Jahren neu entwickelten nicht steroidalen Antiphlogistika und Opioide vorgestellt.

 
  • Literatur

  • 1 Alef M, Burger M, Göbel T et al. Empfehlungen für die Schmerztherapie bei Kleintieren. ITIS (Initiative tiermedizinische Schmerztherapie) Frankfurt: 2012 Im Internet: www.i-tis.de Stand: 30.10.2013
  • 2 Beata C, Flipo RM, Genevois JP et al. Management of canine osteoarthritis in 50 questions. Lyon: Merial; 2007: 1-54
  • 3 Bockstahler B. Moderne Behandlungskonzepte caniner und feliner Osteoarthrosen. Prakt Tierarzt 2013; 94 (1): 26-32
  • 4 Casadesus A. 39-week toxicity study in Beagle dogs with repeated oral administration 8UR-8880 and an 8-week recovery period. Vétoquinol data on file 2005 CD02/8317T
  • 5 Cox SR, Liao S, Payne-Johnson M et al. Population pharmacokinetics of mavacoxib in osteoarthritic dogs. J Vet Pharmacol Ther 2011; 34 (1): 1-11
  • 6 Edamura K, King JN, Seewald W et al. Comparison of oral robenacoxib and carprofen for the treatment of osteoarthritis in dogs: a randomized clinical trial. J Vet Med Sci 2012; 74 (9): 1121-1131
  • 7 EMEA. Committee for Veterinary Medicinal Products, European Agency for the Evaluation of Medicinal Products. Recuvyra: EPAR – Public assessment report. Im Internet: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/document/document_detail.jsp?webContentId=WC500116193&mid=WC0b01ac058009a3dc Stand: 30.10.2013
  • 8 EMEA. Committee for Veterinary Medicinal Products, European Agency for the Evaluation of Medicinal Products. Trocoxil – Scientific discussion. Im Internet: http://www.emea.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/veterinary/000132/WC500069277.pdf Stand: 30.10.2013
  • 9 EMEA. Committee for Veterinary Medicinal Products, European Agency for the Evaluation of Medicinal Products. Robenacoxib – Scientific discussion. Im Internet: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/medicines/000127/vet_med_000154.jsp&mid=WC0b01ac058001fa1c Stand: 30.10.2013
  • 10 Engert M, Tacke S. Der Einsatz von Opioiden bei Hund und Katze. Warum ist die pharmakologische Wirkung für das Verständnis der klinischen Wirkung so wichtig?. Vet Spiegel 2008; 18 (3): 136-142
  • 11 Erhardt W, Henke J, Haberstroh J, Baumgärtner C, Tacke S. Anästhesie und Analgesie beim Klein- und Heimtier sowie bei Vögeln, Reptilien, Amphibien und Fischen. 2. Aufl. Stuttgart, New York: Schattauer; 2012
  • 12 Fox SM. Multimodal management of canine osteoarthritis. In: Fox SM, ed. Chronic Pain in Small Animal Medicine. London: Manson Publishing Ltd; 2010: 189-201
  • 13 Freise KJ, Linton DD, Newbound GC et al. Population pharmacokinetics of transdermal fentanyl solution following a single dose administered prior to soft tissue and orthopedic surgery in dogs. J Vet Pharmacol Ther 2012; 35: 65-72
  • 14 Freise KJ, Newbound GC, Tudan C et al. Pharmacokinetics and the effect of application site on a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. J Vet Pharmacol Ther 2012; 35: 273-233
  • 15 Freise KJ, Newbound GC, Tudan C et al. Naloxone reversal of an overdose of a novel, long-acting transdermal fentanyl solution in laboratory Beagles. J Vet Pharmacol Ther 2012; 35: 45-51
  • 16 Gaynor JS, Muir III WW. Handbook of Veterinary Pain Management. 2 ed. St. Louis, London: Mosby Elsevier; 2009
  • 17 Grandemange E, Fournel S, Woehrlé F. Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. J Small Anim Pract 2013; 54 (6): 304-312
  • 18 Gruet P, Seewald W, King JN. Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial. BMC Vet Res 2013; 9 (1): 92
  • 19 Henke J, Erhardt W. Schmerzmanagement bei Klein- und Heimtieren. Stuttgart: Enke; 2001
  • 20 Innes JF, Clayton J, Lascelles BD. Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Vet Rec 2010; 166 (8): 226-230
  • 21 Jeunesse E. Disposition of cimicoxib in the healthy and renal-impaired dog. Vétoquinol data on file 2008 3008P5F2
  • 22 Jung M, Lees P, Seewald W et al. Analytical determination and pharmacokinetics of robenacoxib in the dog. J Vet Pharmacol Ther 2009; 32 (1): 41-48
  • 23 Kamata M, King JN, Seewald W et al. Comparison of injectable robenacoxib versus meloxicam for peri-operative use in cats: results of a randomised clinical trial. Vet J 2012; 193 (1): 114-118
  • 24 Kukanich B, Clark TP. The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs. J Vet Pharmacol Ther 2012; 35: 3-19
  • 25 Kukanich B, Bidgood T, Knesel O. Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs. NSAID Technical Bulletin Pfizer; 2009: 1-17
  • 26 Lascelles BD, McFarland JM, Swann H. Guidelines for safe and effective use of NSAIDs in dogs. Vet Ther 2005; 6 (3): 237-251
  • 27 Lees P, Alexander-Bowman S, Hummel BD et al. Pharmacokinetics and pharmacodynamics of mavacoxib in the dog. J Vet Pharmacol Ther 2009; 32: 105-106
  • 28 Linton DD, Wilson MG, Newbound GC et al. The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study. J Vet Pharmacol Ther 2012; 35: 53-64
  • 29 von Manteufel F. Wie Hunde beweglich bleiben – adäquate Langzeittherapie älterer Arthrosepatienten. kleintier konkret 2012; (S1): 3-6
  • 30 Otto K. Schmerztherapie bei Klein-, Heim- und Versuchstieren. Berlin: Blackwell Wissenschaftsverlag; 2001
  • 31 Papich MG. An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals. Vet Clin North Am Small Anim Pract 2008; 38 (6): 1243-1266
  • 32 Reymond N, Speranza C, Gruet P et al. Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized, noninferiority clinical trial J Vet Pharmacol Ther 2012; 35 (2): 175-183
  • 33 Rosin P, Tacke S. Methadon zur Neuroleptanalgesie beim Hund. ZiVet 2011; 1-7
  • 34 Rougier S. Assessment of the efficacy and safety of V3008 when compared to firocoxib (Previcox®) in the relief of pain and inflammation of osteoarthritic origin in dogs. Vétoquinol data on file 2008 3008C1F1
  • 35 Sanderson RO, Beata C, Flipo RM et al. Systematic review of the management of canine osteoarthritis. Vet Rec 2009; 164 (14): 418-424
  • 36 Sano T, King JN, Seewald W et al. Comparison of oral robenacoxib and ketoprofen for the treatment of acute pain and inflammation associated with musculoskeletal disorders in cats: a randomised clinical trial. Vet J 2012; 193 (2): 397-403
  • 37 Savides MC, Pohland RC, Wilkie DA et al. The margin of safety of a single application of transdermal fentanyl solution when administered at multiples of the therapeutic dose to laboratory dogs. J Vet Pharmacol Ther 2012; 35: 35-43
  • 38 Stankewitz A, Valet M, Schulz E et al. Pain sensitisers exhibit grey matter changes after repetitive pain exposure: a longitudinal voxel-based morphometry study. Pain 2013; 154 (9): 1732-1737
  • 39 Thiel H, Roewer N. Anästhesiologische Pharmakotherapie. Allgemeine und spezielle Pharmakologie in Anästhesie, Intensivmedizin, Notfallmedizin und Schmerztherapie. Stuttgart: Thieme; 2004
  • 40 Voute H. V3008 – 26-week oral (tablets) safety study in the Beagle dog. Vétoquinol data on file 2008 3008T4F1