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Semin Respir Crit Care Med 2014; 35(01): 129-144
DOI: 10.1055/s-0033-1363458
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

High-Resolution CT of Interstitial Lung Disease: A Continuous Evolution

Simon L. F. Walsh
1   Department of Radiology, Royal Brompton Hospital, London, United Kingdom
,
David M. Hansell
1   Department of Radiology, Royal Brompton Hospital, London, United Kingdom
› Author Affiliations
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Publication History

Publication Date:
30 January 2014 (online)

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Abstract

Before the advent of high-resolution computed tomography (HRCT), the role of imaging, chest radiography in particular, in the management of patients with interstitial lung disease was limited. In the past 25 years, this has radically changed. HRCT has transformed the diagnostic landscape by providing detailed cross-sectional imaging of the lungs, which permit ready identification of a variety of different interstitial lung diseases. Although the position of HRCT as the dominant imaging technique for interstitial lung disease has remained unchallenged since its introduction in the late 1980s, the roles assumed by HRCT have undergone a steady evolution. This evolution has occurred in stages. The first investigations of HRCT in interstitial lung disease during the late 1980s and early 1990s marked a golden era of HRCT-pathologic correlative studies, typified by the work of Müller and Miller. It was this groundbreaking work that defined basic HRCT patterns, correlated to histopathologic appearances, which underpin the pattern recognition approach used to interpret HRCT images to this day. Subsequently, attention turned to issues of disease reversibility and responsiveness and how this could be predicted by HRCT. At the turn of the millennium, the previously long accepted belief in histopathological diagnosis as the reference standard in interstitial lung disease gave way to a growing perception that histopathology was not infallible. This change in diagnostic thinking arguably has had the biggest impact on how HRCT's role subsequently evolved. Recently, HRCT data have been integrated with pulmonary function in staging models to predict prognosis particularly in idiopathic fibrosing lung disease. This article reviews these stages of evolution. The emergence of the multidisciplinary approach to diagnosis will also be considered.

Keywords

HRCT - interstitial lung disease - CT-pathological correlative studies - prognostication - staging
 

  • References

  • 1 Epler GR, McLoud TC, Gaensler EA, Mikus JP, Carrington CB. Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 1978; 298 (17) 934-939
    CrossrefPubMedGoogle Scholar
  • 2 Aberle DR, Gamsu G, Ray CS. High-resolution CT of benign asbestos-related diseases: clinical and radiographic correlation. AJR Am J Roentgenol 1988; 151 (5) 883-891
    CrossrefPubMedGoogle Scholar
  • 3 Aberle DR, Gamsu G, Ray CS, Feuerstein IM. Asbestos-related pleural and parenchymal fibrosis: detection with high-resolution CT. Radiology 1988; 166 (3) 729-734
    PubMedGoogle Scholar
  • 4 Friedman AC, Fiel SB, Fisher MS, Radecki PD, Lev-Toaff AS, Caroline DF. Asbestos-related pleural disease and asbestosis: a comparison of CT and chest radiography. AJR Am J Roentgenol 1988; 150 (2) 269-275
    CrossrefPubMedGoogle Scholar
  • 5 Staples CA, Gamsu G, Ray CS, Webb WR. High resolution computed tomography and lung function in asbestos-exposed workers with normal chest radiographs. Am Rev Respir Dis 1989; 139 (6) 1502-1508
    CrossrefPubMedGoogle Scholar
  • 6 Brauner MW, Grenier P, Mompoint D, Lenoir S, de Crémoux H. Pulmonary sarcoidosis: evaluation with high-resolution CT. Radiology 1989; 172 (2) 467-471
    CrossrefPubMedGoogle Scholar
  • 7 Müller NL, Mawson JB, Mathieson JR, Abboud R, Ostrow DN, Champion P. Sarcoidosis: correlation of extent of disease at CT with clinical, functional, and radiographic findings. Radiology 1989; 171 (3) 613-618
    CrossrefPubMedGoogle Scholar
  • 8 Stein MG, Mayo J, Müller N, Aberle DR, Webb WR, Gamsu G. Pulmonary lymphangitic spread of carcinoma: appearance on CT scans. Radiology 1987; 162 (2) 371-375
    PubMedGoogle Scholar
  • 9 Strickland B, Strickland NH. The value of high definition, narrow section computed tomography in fibrosing alveolitis. Clin Radiol 1988; 39 (6) 589-594
    CrossrefPubMedGoogle Scholar
  • 10 Müller NL, Chiles C, Kullnig P. Pulmonary lymphangiomyomatosis: correlation of CT with radiographic and functional findings. Radiology 1990; 175 (2) 335-339
    PubMedGoogle Scholar
  • 11 Genereux GP. The Fleischner lecture: computed tomography of diffuse pulmonary disease. J Thorac Imaging 1989; 4 (3) 50-87
    CrossrefPubMedGoogle Scholar
  • 12 McLoud TC, Carrington CB, Gaensler EA. Diffuse infiltrative lung disease: a new scheme for description. Radiology 1983; 149 (2) 353-363
    PubMedGoogle Scholar
  • 13 Gould DM, Dalrymple GV. A radiological analysis of disseminated lung disease. Am J Med Sci 1959; 238: 621-637
    PubMedGoogle Scholar
  • 14 Mathieson JR, Mayo JR, Staples CA, Müller NL. Chronic diffuse infiltrative lung disease: comparison of diagnostic accuracy of CT and chest radiography. Radiology 1989; 171 (1) 111-116
    CrossrefPubMedGoogle Scholar
  • 15 Grenier P, Valeyre D, Cluzel P, Brauner MW, Lenoir S, Chastang C. Chronic diffuse interstitial lung disease: diagnostic value of chest radiography and high-resolution CT. Radiology 1991; 179 (1) 123-132
    PubMedGoogle Scholar
  • 16 Padley SP, Hansell DM, Flower CD, Jennings P. Comparative accuracy of high resolution computed tomography and chest radiography in the diagnosis of chronic diffuse infiltrative lung disease. Clin Radiol 1991; 44 (4) 222-226
    CrossrefPubMedGoogle Scholar
  • 17 Bergin CJ, Coblentz CL, Chiles C, Bell DY, Castellino RA. Chronic lung diseases: specific diagnosis by using CT. AJR Am J Roentgenol 1989; 152 (6) 1183-1188
    CrossrefPubMedGoogle Scholar
  • 18 Tung KT, Wells AU, Rubens MB, Kirk JM, du Bois RM, Hansell DM. Accuracy of the typical computed tomographic appearances of fibrosing alveolitis. Thorax 1993; 48 (4) 334-338
    CrossrefPubMedGoogle Scholar
  • 19 Akira M, Higashihara T, Yokoyama K , et al. Radiographic type p pneumoconiosis: high-resolution CT. Radiology 1989; 171 (1) 117-123
    PubMedGoogle Scholar
  • 20 Remy-Jardin M, Degreef JM, Beuscart R, Voisin C, Remy J. Coal worker's pneumoconiosis: CT assessment in exposed workers and correlation with radiographic findings. Radiology 1990; 177 (2) 363-371
    CrossrefPubMedGoogle Scholar
  • 21 Bergin CJ, Müller NL. CT in the diagnosis of interstitial lung disease. AJR Am J Roentgenol 1985; 145 (3) 505-510
    CrossrefPubMedGoogle Scholar
  • 22 Todo G, Ito H, Nakano Y , et al. High resolution CT (HR-CT) for the evaluation of pulmonary peripheral disorders [in Japanese]. Rinsho Hoshasen 1982; 27 (12) 1319-1326
    PubMedGoogle Scholar
  • 23 Zerhouni EA, Naidich DP, Stitik FP, Khouri NF, Siegelman SS. Computed tomography of the pulmonary parenchyma. Part 2: Interstitial disease. J Thorac Imaging 1985; 1 (1) 54-64
    CrossrefPubMedGoogle Scholar
  • 24 Müller NL, Miller RR, Webb WR, Evans KG, Ostrow DN. Fibrosing alveolitis: CT-pathologic correlation. Radiology 1986; 160 (3) 585-588
    CrossrefPubMedGoogle Scholar
  • 25 Müller NL, Staples CA, Miller RR, Vedal S, Thurlbeck WM, Ostrow DN. Disease activity in idiopathic pulmonary fibrosis: CT and pathologic correlation. Radiology 1987; 165 (3) 731-734
    PubMedGoogle Scholar
  • 26 Müller NL, Miller RR. Computed tomography of chronic diffuse infiltrative lung disease. Part 2. Am Rev Respir Dis 1990; 142 (6, Pt 1) 1440-1448
    CrossrefPubMedGoogle Scholar
  • 27 Müller NL, Miller RR. Computed tomography of chronic diffuse infiltrative lung disease. Part 1. Am Rev Respir Dis 1990; 142 (5) 1206-1215
    CrossrefPubMedGoogle Scholar
  • 28 Munk PL, Müller NL, Miller RR, Ostrow DN. Pulmonary lymphangitic carcinomatosis: CT and pathologic findings. Radiology 1988; 166 (3) 705-709
    PubMedGoogle Scholar
  • 29 Müller NL, Kullnig P, Miller RR. The CT findings of pulmonary sarcoidosis: analysis of 25 patients. AJR Am J Roentgenol 1989; 152 (6) 1179-1182
    CrossrefPubMedGoogle Scholar
  • 30 Silver SF, Müller NL, Miller RR, Lefcoe MS. Hypersensitivity pneumonitis: evaluation with CT. Radiology 1989; 173 (2) 441-445
    PubMedGoogle Scholar
  • 31 Müller NL, Staples CA, Miller RR. Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients. AJR Am J Roentgenol 1990; 154 (5) 983-987
    CrossrefPubMedGoogle Scholar
  • 32 Müller NL, Miller RR. Ground-glass attenuation, nodules, alveolitis, and sarcoid granulomas. Radiology 1993; 189 (1) 31-32
    CrossrefPubMedGoogle Scholar
  • 33 Leung AN, Miller RR, Müller NL. Parenchymal opacification in chronic infiltrative lung diseases: CT-pathologic correlation. Radiology 1993; 188 (1) 209-214
    CrossrefPubMedGoogle Scholar
  • 34 Godwin JD, Müller NL, Takasugi JE. Pulmonary alveolar proteinosis: CT findings. Radiology 1988; 169 (3) 609-613
    PubMedGoogle Scholar
  • 35 Mayo JR, Müller NL, Road J, Sisler J, Lillington G. Chronic eosinophilic pneumonia: CT findings in six cases. AJR Am J Roentgenol 1989; 153 (4) 727-730
    CrossrefPubMedGoogle Scholar
  • 36 Primack SL, Hartman TE, Ikezoe J, Akira M, Sakatani M, Müller NL. Acute interstitial pneumonia: radiographic and CT findings in nine patients. Radiology 1993; 188 (3) 817-820
    CrossrefPubMedGoogle Scholar
  • 37 Wells AU, Rubens MB, du Bois RM, Hansell DM. Serial CT in fibrosing alveolitis: prognostic significance of the initial pattern. AJR Am J Roentgenol 1993; 161 (6) 1159-1165
    CrossrefPubMedGoogle Scholar
  • 38 Ichikado K, Johkoh T, Ikezoe J , et al. Acute interstitial pneumonia: high-resolution CT findings correlated with pathology. AJR Am J Roentgenol 1997; 168 (2) 333-338
    CrossrefPubMedGoogle Scholar
  • 39 Itoh H, Tokunaga S, Asamoto H , et al. Radiologic-pathologic correlations of small lung nodules with special reference to peribronchiolar nodules. AJR Am J Roentgenol 1978; 130 (2) 223-231
    CrossrefPubMedGoogle Scholar
  • 40 Johkoh T, Ikezoe J, Tomiyama N , et al. CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests. AJR Am J Roentgenol 1992; 158 (6) 1217-1222
    CrossrefPubMedGoogle Scholar
  • 41 Nishimura K, Itoh H, Kitaichi M, Nagai S, Izumi T. Pulmonary sarcoidosis: correlation of CT and histopathologic findings. Radiology 1993; 189 (1) 105-109
    PubMedGoogle Scholar
  • 42 Nishimura K, Itoh H, Kitaichi M, Nagai S, Izumi T. CT and pathological correlation of pulmonary sarcoidosis. Semin Ultrasound CT MR 1995; 16 (5) 361-370
    CrossrefPubMedGoogle Scholar
  • 43 Nishimura K, Izumi T, Kitaichi M, Nagai S, Itoh H. The diagnostic accuracy of high-resolution computed tomography in diffuse infiltrative lung diseases. Chest 1993; 104 (4) 1149-1155
    CrossrefPubMedGoogle Scholar
  • 44 Nishimura K, Kitaichi M, Izumi T, Kanaoka M, Itoh H. CT pathologic correlative study of bronchiolitis obliterans organizing pneumonia [in Japanese]. Rinsho Hoshasen 1989; 34 (1) 127-136
    PubMedGoogle Scholar
  • 45 Nishimura K, Kitaichi M, Izumi T , et al. Correlation of CT and pathologic findings of pulmonary lymphangioleiomyomatosis [in Japanese]. Nihon Kyobu Shikkan Gakkai Zasshi 1990; 28 (5) 691-697
    PubMedGoogle Scholar
  • 46 Nishimura K, Kitaichi M, Izumi T, Nagai S, Kanaoka M, Itoh H. Usual interstitial pneumonia: histologic correlation with high-resolution CT. Radiology 1992; 182 (2) 337-342
    CrossrefPubMedGoogle Scholar
  • 47 Hansell DM, Bankier AA, MacMahon H, McLoud TC, Müller NL, Remy J. Fleischner Society: glossary of terms for thoracic imaging. Radiology 2008; 246 (3) 697-722
    CrossrefPubMedGoogle Scholar
  • 48 Goldin J, Elashoff R, Kim HJ , et al. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study. Chest 2009; 136 (5) 1333-1340
    CrossrefPubMedGoogle Scholar
  • 49 Lynch DA, Webb WR, Gamsu G, Stulbarg M, Golden J. Computed tomography in pulmonary sarcoidosis. J Comput Assist Tomogr 1989; 13 (3) 405-410
    CrossrefPubMedGoogle Scholar
  • 50 Sundaram B, Gross BH, Oh E, Müller N, Myles JD, Kazerooni EA. Reader accuracy and confidence in diagnosing diffuse lung disease on high-resolution computed tomography of the lungs: impact of sampling frequency. Acta Radiol 2008; 49 (8) 870-875
    CrossrefPubMedGoogle Scholar
  • 51 Watadani T, Sakai F, Johkoh T , et al. Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology 2013; 266 (3) 936-944
    CrossrefPubMedGoogle Scholar
  • 52 Remy-Jardin M, Giraud F, Remy J, Copin MC, Gosselin B, Duhamel A. Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation. Radiology 1993; 189 (3) 693-698
    CrossrefPubMedGoogle Scholar
  • 53 Katzenstein AL, Fiorelli RF. Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance. Am J Surg Pathol 1994; 18 (2) 136-147
    CrossrefPubMedGoogle Scholar
  • 54 Harrison NK, Glanville AR, Strickland B , et al. Pulmonary involvement in systemic sclerosis: the detection of early changes by thin section CT scan, bronchoalveolar lavage and 99mTc-DTPA clearance. Respir Med 1989; 83 (5) 403-414
    CrossrefPubMedGoogle Scholar
  • 55 Wells AU, Cullinan P, Hansell DM , et al. Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 1994; 149 (6) 1583-1590
    CrossrefPubMedGoogle Scholar
  • 56 Chan TY, Hansell DM, Rubens MB, du Bois RM, Wells AU. Cryptogenic fibrosing alveolitis and the fibrosing alveolitis of systemic sclerosis: morphological differences on computed tomographic scans. Thorax 1997; 52 (3) 265-270
    CrossrefPubMedGoogle Scholar
  • 57 Katzenstein AL, Myers JL. Nonspecific interstitial pneumonia and the other idiopathic interstitial pneumonias: classification and diagnostic criteria. Am J Surg Pathol 2000; 24 (1) 1-3
    CrossrefPubMedGoogle Scholar
  • 58 Bjoraker JA, Ryu JH, Edwin MK , et al. Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 157 (1) 199-203
    CrossrefPubMedGoogle Scholar
  • 59 Fujita J, Yoshinouchi T, Ohtsuki Y , et al. Non-specific interstitial pneumonia as pulmonary involvement of systemic sclerosis. Ann Rheum Dis 2001; 60 (3) 281-283
    CrossrefPubMedGoogle Scholar
  • 60 Howling SJ, Evans TW, Hansell DM. The significance of bronchial dilatation on CT in patients with adult respiratory distress syndrome. Clin Radiol 1998; 53 (2) 105-109
    CrossrefPubMedGoogle Scholar
  • 61 Cottin V, Donsbeck AV, Revel D, Loire R, Cordier JF. Nonspecific interstitial pneumonia. Individualization of a clinicopathologic entity in a series of 12 patients. Am J Respir Crit Care Med 1998; 158 (4) 1286-1293
    CrossrefPubMedGoogle Scholar
  • 62 Park JS, Lee KS, Kim JS , et al. Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients. Radiology 1995; 195 (3) 645-648
    CrossrefPubMedGoogle Scholar
  • 63 Mino M, Noma S, Taguchi Y, Tomii K, Kohri Y, Oida K. Pulmonary involvement in polymyositis and dermatomyositis: sequential evaluation with CT. AJR Am J Roentgenol 1997; 169 (1) 83-87
    CrossrefPubMedGoogle Scholar
  • 64 Tazelaar HD, Viggiano RW, Pickersgill J, Colby TV. Interstitial lung disease in polymyositis and dermatomyositis. Clinical features and prognosis as correlated with histologic findings. Am Rev Respir Dis 1990; 141 (3) 727-733
    CrossrefPubMedGoogle Scholar
  • 65 Primack SL, Hartman TE, Hansell DM, Müller NL. End-stage lung disease: CT findings in 61 patients. Radiology 1993; 189 (3) 681-686
    CrossrefPubMedGoogle Scholar
  • 66 Wells AU, King AD, Rubens MB, Cramer D, du Bois RM, Hansell DM. Lone cryptogenic fibrosing alveolitis: a functional-morphologic correlation based on extent of disease on thin-section computed tomography. Am J Respir Crit Care Med 1997; 155 (4) 1367-1375
    CrossrefPubMedGoogle Scholar
  • 67 Cottin V, Cordier JF. The syndrome of combined pulmonary fibrosis and emphysema. Chest 2009; 136 (1) 1-2
    CrossrefPubMedGoogle Scholar
  • 68 Wells AU, Desai SR, Rubens MB , et al. Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography. Am J Respir Crit Care Med 2003; 167 (7) 962-969
    CrossrefPubMedGoogle Scholar
  • 69 Schmidt SL, Nambiar AM, Tayob N , et al. Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema. Eur Respir J 2011; 38 (1) 176-183
    CrossrefPubMedGoogle Scholar
  • 70 Corte TJ, Wort SJ, MacDonald PS , et al. Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia. Respirology 2012; 17 (4) 674-680
    CrossrefPubMedGoogle Scholar
  • 71 American Thoracic Society. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000; 161 (2, Pt 1) 646-664
    CrossrefPubMedGoogle Scholar
  • 72 Hunninghake GW, Zimmerman MB, Schwartz DA , et al. Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2001; 164 (2) 193-196
    CrossrefPubMedGoogle Scholar
  • 73 Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 1998; 157 (4, Pt 1) 1301-1315
    CrossrefPubMedGoogle Scholar
  • 74 Liebow AA. Definition and classification of interstitial pneumonias in human pathology. Progr Respir Res 1977; 8: 1-33
    PubMedGoogle Scholar
  • 75 Liebow AA. The Interstitial Pneumonias. New York: Grune and Stratton; 1969
    Google Scholar
  • 76 Nicholson AG, Addis BJ, Bharucha H , et al. Inter-observer variation between pathologists in diffuse parenchymal lung disease. Thorax 2004; 59 (6) 500-505
    CrossrefPubMedGoogle Scholar
  • 77 Flaherty KR, Travis WD, Colby TV , et al. Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med 2001; 164 (9) 1722-1727
    CrossrefPubMedGoogle Scholar
  • 78 Monaghan H, Wells AU, Colby TV, du Bois RM, Hansell DM, Nicholson AG. Prognostic implications of histologic patterns in multiple surgical lung biopsies from patients with idiopathic interstitial pneumonias. Chest 2004; 125 (2) 522-526
    CrossrefPubMedGoogle Scholar
  • 79 Flaherty KR, King Jr TE, Raghu G , et al. Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?. Am J Respir Crit Care Med 2004; 170 (8) 904-910
    CrossrefPubMedGoogle Scholar
  • 80 American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165 (2) 277-304
    CrossrefPubMedGoogle Scholar
  • 81 Raghu G, Mageto YN, Lockhart D, Schmidt RA, Wood DE, Godwin JD. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease: a prospective study. Chest 1999; 116 (5) 1168-1174
    CrossrefPubMedGoogle Scholar
  • 82 Aziz ZA, Wells AU, Bateman ED , et al. Interstitial lung disease: effects of thin-section CT on clinical decision making. Radiology 2006; 238 (2) 725-733
    CrossrefPubMedGoogle Scholar
  • 83 Travis WD, Hunninghake G, King Jr TE , et al. Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project. Am J Respir Crit Care Med 2008; 177 (12) 1338-1347
    CrossrefPubMedGoogle Scholar
  • 84 Bullard JE, Wert SE, Whitsett JA, Dean M, Nogee LM. ABCA3 mutations associated with pediatric interstitial lung disease. Am J Respir Crit Care Med 2005; 172 (8) 1026-1031
    CrossrefPubMedGoogle Scholar
  • 85 Amin RS, Wert SE, Baughman RP , et al. Surfactant protein deficiency in familial interstitial lung disease. J Pediatr 2001; 139 (1) 85-92
    CrossrefPubMedGoogle Scholar
  • 86 Fell CD, Martinez FJ, Liu LX , et al. Clinical predictors of a diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2010; 181 (8) 832-837
    CrossrefPubMedGoogle Scholar
  • 87 Nagai S, Kitaichi M, Itoh H, Nishimura K, Izumi T, Colby TV. Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP. Eur Respir J 1998; 12 (5) 1010-1019
    CrossrefPubMedGoogle Scholar
  • 88 Selman M, Pardo A, Barrera L , et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med 2006; 173 (2) 188-198
    CrossrefPubMedGoogle Scholar
  • 89 Raghu G, Collard HR, Egan JJ , et al; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011; 183 (6) 788-824
    CrossrefPubMedGoogle Scholar
  • 90 Swensen SJ, Aughenbaugh GL, Myers JL. Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lung. Radiology 1997; 205 (1) 229-234
    CrossrefPubMedGoogle Scholar
  • 91 Sverzellati N, Wells AU, Tomassetti S , et al. Biopsy-proved idiopathic pulmonary fibrosis: spectrum of nondiagnostic thin-section CT diagnoses. Radiology 2010; 254 (3) 957-964
    CrossrefPubMedGoogle Scholar
  • 92 Johkoh T, Müller NL, Cartier Y , et al. Idiopathic interstitial pneumonias: diagnostic accuracy of thin-section CT in 129 patients. Radiology 1999; 211 (2) 555-560
    CrossrefPubMedGoogle Scholar
  • 93 MacDonald SL, Rubens MB, Hansell DM , et al. Nonspecific interstitial pneumonia and usual interstitial pneumonia: comparative appearances at and diagnostic accuracy of thin-section CT. Radiology 2001; 221 (3) 600-605
    CrossrefPubMedGoogle Scholar
  • 94 Zompatori M, Calabrò E, Chetta A, Chiari G, Marangio E, Olivieri D. Chronic hypersensitivity pneumonitis or idiopathic pulmonary fibrosis? Diagnostic role of high resolution Computed Tomography (HRCT) [in Italian]. Radiol Med (Torino) 2003; 106 (3) 135-146
    PubMedGoogle Scholar
  • 95 Padley SP, Padhani AR, Nicholson A, Hansell DM. Pulmonary sarcoidosis mimicking cryptogenic fibrosing alveolitis on CT. Clin Radiol 1996; 51 (11) 807-810
    CrossrefPubMedGoogle Scholar
  • 96 Lloyd CR, Nicholson AG, Wells AU, Hansell DM. Non-Langerhans histiocytosis mimicking sarcoidosis on high-resolution computed tomography. J Thorac Imaging 2010; 25 (4) W133–W135
    PubMedGoogle Scholar
  • 97 Scadding JG, Hinson KF. Diffuse fibrosing alveolitis (diffuse interstitial fibrosis of the lungs). Correlation of histology at biopsy with prognosis. Thorax 1967; 22 (4) 291-304
    CrossrefPubMedGoogle Scholar
  • 98 Stack BH, Choo-Kang YF, Heard BE. The prognosis of cryptogenic fibrosing alveolitis. Thorax 1972; 27 (5) 535-542
    CrossrefPubMedGoogle Scholar
  • 99 Crystal RG, Fulmer JD, Roberts WC, Moss ML, Line BR, Reynolds HY. Idiopathic pulmonary fibrosis. Clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med 1976; 85 (6) 769-788
    CrossrefPubMedGoogle Scholar
  • 100 Winterbauer RH, Hammar SP, Hallman KO , et al. Diffuse interstitial pneumonitis. Clinicopathologic correlations in 20 patients treated with prednisone/azathioprine. Am J Med 1978; 65 (4) 661-672
    CrossrefPubMedGoogle Scholar
  • 101 Turner-Warwick M, Burrows B, Johnson A. Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax 1980; 35 (3) 171-180
    CrossrefPubMedGoogle Scholar
  • 102 DeRemee RA, Harrison Jr EG, Andersen HA. The concept of classic interstitial pneumonitis-fibrosis (CIP-F) as a clinicopathologic syndrome. Chest 1972; 61 (3) 213-220
    CrossrefPubMedGoogle Scholar
  • 103 Carrington CB, Gaensler EA, Coutu RE, FitzGerald MX, Gupta RG. Natural history and treated course of usual and desquamative interstitial pneumonia. N Engl J Med 1978; 298 (15) 801-809
    CrossrefPubMedGoogle Scholar
  • 104 Watters LC, Schwarz MI, Cherniack RM , et al. Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy. Am Rev Respir Dis 1987; 135 (3) 696-704
    PubMedGoogle Scholar
  • 105 Keogh BA, Crystal RG. Alveolitis: the key to the interstitial lung disorders. Thorax 1982; 37 (1) 1-10
    CrossrefPubMedGoogle Scholar
  • 106 Crystal RG, Gadek JE, Ferrans VJ, Fulmer JD, Line BR, Hunninghake GW. Interstitial lung disease: current concepts of pathogenesis, staging and therapy. Am J Med 1981; 70 (3) 542-568
    CrossrefPubMedGoogle Scholar
  • 107 Hunninghake GW, Crystal RG. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 1981; 305 (8) 429-434
    CrossrefPubMedGoogle Scholar
  • 108 Line BR, Hunninghake GW, Keogh BA, Jones AE, Johnston GS, Crystal RG. Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies, and bronchoalveolar lavage. Am Rev Respir Dis 1981; 123 (4, Pt 1): 440-446
    PubMedGoogle Scholar
  • 109 Remy-Jardin M, Giraud F, Remy J, Wattinne L, Wallaert B, Duhamel A. Pulmonary sarcoidosis: role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment. Radiology 1994; 191 (3) 675-680
    PubMedGoogle Scholar
  • 110 Drago A, Battaglia M, Rimondi MR , et al. Signs of inflammatory activity in thoracic sarcoidosis. A high-resolution computerized tomography study [in Italian]. Radiol Med (Torino) 1995; 89 (1–2) 57-64
    PubMedGoogle Scholar
  • 111 Winterbauer RH. Current concepts in and modes for measurement of activity in interstitial lung disease. Curr Opin Pulm Med 1995; 1 (5) 358-362
    PubMedGoogle Scholar
  • 112 Lee JS, Gong G, Song KS, Kim DS, Lim TH. Usual interstitial pneumonia: relationship between disease activity and the progression of honeycombing at thin-section computed tomography. J Thorac Imaging 1998; 13 (3) 199-203
    CrossrefPubMedGoogle Scholar
  • 113 Oberstein A, von Zitzewitz H, Schweden F, Müller-Quernheim J. Noninvasive evaluation of the inflammatory activity in sarcoidosis with high-resolution computed tomography. Sarcoidosis Vasc Diffuse Lung Dis 1997; 14 (1) 65-72
    PubMedGoogle Scholar
  • 114 Leung AN, Brauner MW, Caillat-Vigneron N, Valeyre D, Grenier P. Sarcoidosis activity: correlation of HRCT findings with those of 67Ga scanning, bronchoalveolar lavage, and serum angiotensin-converting enzyme assay. J Comput Assist Tomogr 1998; 22 (2) 229-234
    CrossrefPubMedGoogle Scholar
  • 115 Gay SE, Kazerooni EA, Toews GB , et al. Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med 1998; 157 (4, Pt 1) 1063-1072
    CrossrefPubMedGoogle Scholar
  • 116 Hartman TE, Primack SL, Kang EY , et al. Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia. Assessment with serial CT. Chest 1996; 110 (2) 378-382
    CrossrefPubMedGoogle Scholar
  • 117 Murdoch J, Müller NL. Pulmonary sarcoidosis: changes on follow-up CT examination. AJR Am J Roentgenol 1992; 159 (3) 473-477
    CrossrefPubMedGoogle Scholar
  • 118 Brauner MW, Lenoir S, Grenier P, Cluzel P, Battesti JP, Valeyre D. Pulmonary sarcoidosis: CT assessment of lesion reversibility. Radiology 1992; 182 (2) 349-354
    CrossrefPubMedGoogle Scholar
  • 119 Remy-Jardin M, Remy J, Wallaert B, Müller NL. Subacute and chronic bird breeder hypersensitivity pneumonitis: sequential evaluation with CT and correlation with lung function tests and bronchoalveolar lavage. Radiology 1993; 189 (1) 111-118
    CrossrefPubMedGoogle Scholar
  • 120 Soler P, Bergeron A, Kambouchner M , et al. Is high-resolution computed tomography a reliable tool to predict the histopathological activity of pulmonary Langerhans cell histiocytosis?. Am J Respir Crit Care Med 2000; 162 (1) 264-270
    CrossrefPubMedGoogle Scholar
  • 121 Flaherty KR, Thwaite EL, Kazerooni EA , et al. Radiological versus histological diagnosis in UIP and NSIP: survival implications. Thorax 2003; 58 (2) 143-148
    CrossrefPubMedGoogle Scholar
  • 122 Kim EJ, Elicker BM, Maldonado F , et al. Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J 2010; 35 (6) 1322-1328
    CrossrefPubMedGoogle Scholar
  • 123 Mogulkoc N, Brutsche MH, Bishop PW, Greaves SM, Horrocks AW, Egan JJ ; Greater Manchester Pulmonary Fibrosis Consortium. Pulmonary function in idiopathic pulmonary fibrosis and referral for lung transplantation. Am J Respir Crit Care Med 2001; 164 (1) 103-108
    CrossrefPubMedGoogle Scholar
  • 124 Lynch DA, Godwin JD, Safrin S , et al; Idiopathic Pulmonary Fibrosis Study Group. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med 2005; 172 (4) 488-493
    CrossrefPubMedGoogle Scholar
  • 125 Sumikawa H, Johkoh T, Colby TV , et al. Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival. Am J Respir Crit Care Med 2008; 177 (4) 433-439
    CrossrefPubMedGoogle Scholar
  • 126 Wells AU, Hansell DM, Rubens MB, Cullinan P, Black CM, du Bois RM. The predictive value of appearances on thin-section computed tomography in fibrosing alveolitis. Am Rev Respir Dis 1993; 148 (4, Pt 1): 1076-1082
    CrossrefPubMedGoogle Scholar
  • 127 Sundaram B, Gross BH, Martinez FJ , et al. Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of predominance and distribution of findings. AJR Am J Roentgenol 2008; 191 (4) 1032-1039
    CrossrefPubMedGoogle Scholar
  • 128 Akira M, Inoue Y, Arai T, Okuma T, Kawata Y. Long-term follow-up high-resolution CT findings in non-specific interstitial pneumonia. Thorax 2011; 66 (1) 61-65
    CrossrefPubMedGoogle Scholar
  • 129 Fujimoto K, Taniguchi H, Johkoh T , et al. Acute exacerbation of idiopathic pulmonary fibrosis: high-resolution CT scores predict mortality. Eur Radiol 2012; 22 (1) 83-92
    CrossrefPubMedGoogle Scholar
  • 130 Edey AJ, Devaraj AA, Barker RP, Nicholson AG, Wells AU, Hansell DM. Fibrotic idiopathic interstitial pneumonias: HRCT findings that predict mortality. Eur Radiol 2011; 21 (8) 1586-1593
    CrossrefPubMedGoogle Scholar
  • 131 Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. Eur Radiol 2012; 22 (8) 1672-1679
    CrossrefPubMedGoogle Scholar
  • 132 Akira M, Kozuka T, Yamamoto S, Sakatani M. Computed tomography findings in acute exacerbation of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008; 178 (4) 372-378
    CrossrefPubMedGoogle Scholar
  • 133 Ichikado K, Suga M, Müller NL , et al. Acute interstitial pneumonia: comparison of high-resolution computed tomography findings between survivors and nonsurvivors. Am J Respir Crit Care Med 2002; 165 (11) 1551-1556
    CrossrefPubMedGoogle Scholar
  • 134 Akira M, Sakatani M, Ueda E. Idiopathic pulmonary fibrosis: progression of honeycombing at thin-section CT. Radiology 1993; 189 (3) 687-691
    CrossrefPubMedGoogle Scholar
  • 135 Akira M, Yamamoto S, Hara H, Sakatani M, Ueda E. Serial computed tomographic evaluation in desquamative interstitial pneumonia. Thorax 1997; 52 (4) 333-337
    CrossrefPubMedGoogle Scholar
  • 136 Xaubet A, Agustí C, Luburich P , et al. Pulmonary function tests and CT scan in the management of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 158 (2) 431-436
    CrossrefPubMedGoogle Scholar
  • 137 Lee HY, Lee KS, Jeong YJ , et al. High-resolution CT findings in fibrotic idiopathic interstitial pneumonias with little honeycombing: serial changes and prognostic implications. AJR Am J Roentgenol 2012; 199 (5) 982-989
    CrossrefPubMedGoogle Scholar
  • 138 Flaherty KR, Mumford JA, Murray S , et al. Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia. Am J Respir Crit Care Med 2003; 168 (5) 543-548
    CrossrefPubMedGoogle Scholar
  • 139 Latsi PI, du Bois RM, Nicholson AG , et al. Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. Am J Respir Crit Care Med 2003; 168 (5) 531-537
    CrossrefPubMedGoogle Scholar
  • 140 Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J, Tata LJ. Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax 2006; 61 (11) 980-985
    CrossrefPubMedGoogle Scholar
  • 141 Sulica R, Teirstein AS, Kakarla S, Nemani N, Behnegar A, Padilla ML. Distinctive clinical, radiographic, and functional characteristics of patients with sarcoidosis-related pulmonary hypertension. Chest 2005; 128 (3) 1483-1489
    CrossrefPubMedGoogle Scholar
  • 142 Scadding J. Sarcoidosis. 1st ed. London, UK: Eyre and Spottiswoode; 1967
    Google Scholar
  • 143 Akira M, Kozuka T, Inoue Y, Sakatani M. Long-term follow-up CT scan evaluation in patients with pulmonary sarcoidosis. Chest 2005; 127 (1) 185-191
    CrossrefPubMedGoogle Scholar
  • 144 Collard HR, King Jr TE, Bartelson BB, Vourlekis JS, Schwarz MI, Brown KK. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003; 168 (5) 538-542
    CrossrefPubMedGoogle Scholar
  • 145 King Jr TE, Safrin S, Starko KM , et al. Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis. Chest 2005; 127 (1) 171-177
    CrossrefPubMedGoogle Scholar
  • 146 Egan JJ, Martinez FJ, Wells AU, Williams T. Lung function estimates in idiopathic pulmonary fibrosis: the potential for a simple classification. Thorax 2005; 60 (4) 270-273
    CrossrefPubMedGoogle Scholar
  • 147 Schwartz DA, Helmers RA, Galvin JR , et al. Determinants of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1994; 149 (2, Pt 1) 450-454
    CrossrefPubMedGoogle Scholar
  • 148 Jegal Y, Kim DS, Shim TS , et al. Physiology is a stronger predictor of survival than pathology in fibrotic interstitial pneumonia. Am J Respir Crit Care Med 2005; 171 (6) 639-644
    CrossrefPubMedGoogle Scholar
  • 149 King Jr TE, Tooze JA, Schwarz MI, Brown KR, Cherniack RM. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001; 164 (7) 1171-1181
    CrossrefPubMedGoogle Scholar
  • 150 Hallstrand TS, Boitano LJ, Johnson WC, Spada CA, Hayes JG, Raghu G. The timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis. Eur Respir J 2005; 25 (1) 96-103
    CrossrefPubMedGoogle Scholar
  • 151 Hamada K, Nagai S, Tanaka S , et al. Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis. Chest 2007; 131 (3) 650-656
    CrossrefPubMedGoogle Scholar
  • 152 du Bois RM, Weycker D, Albera C , et al. Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011; 184 (4) 459-466
    CrossrefPubMedGoogle Scholar
  • 153 Ley B, Ryerson CJ, Vittinghoff E , et al. A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann Intern Med 2012; 156 (10) 684-691
    CrossrefPubMedGoogle Scholar
  • 154 Goh NS, Desai SR, Veeraraghavan S , et al. Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med 2008; 177 (11) 1248-1254
    CrossrefPubMedGoogle Scholar
  • 155 Stradling P. Undiagnosable lung disease. BMJ 1962; 1 (5289) 1403-1410
    CrossrefPubMedGoogle Scholar
  • 156 Davies D, Crowther JS, MacFarlane A. Idiopathic progressive pulmonary fibrosis. Thorax 1975; 30 (3) 316-325
    CrossrefPubMedGoogle Scholar
  • 157 Fraisse P, Vandevenne A, Ducolone A, Burghard G. Idiopathic progressive pleuropulmonary fibrosis. Apropos of 2 cases [in French]. Rev Pneumol Clin 1984; 40 (2) 139-143
    PubMedGoogle Scholar
  • 158 Scadding JG. A case of idiopathic cavitation of lung demonstrated at the Postgraduate Medical School of London. BMJ 1966; 1 (5483) 345-348
    CrossrefPubMedGoogle Scholar
  • 159 Shiota S, Shimizu K, Suzuki M , et al. Seven cases of marked pulmonary fibrosis in the upper lobe [in Japanese]. Nihon Kokyuki Gakkai Zasshi 1999; 37 (2) 87-96
    PubMedGoogle Scholar
  • 160 Frankel SK, Cool CD, Lynch DA, Brown KK. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest 2004; 126 (6) 2007-2013
    CrossrefPubMedGoogle Scholar
  • 161 Attili AK, Kazerooni EA, Gross BH, Flaherty KR, Myers JL, Martinez FJ. Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics 2008; 28 (5) 1383-1396; discussion 1396–1398
    CrossrefPubMedGoogle Scholar
  • 162 Hidalgo A, Franquet T, Giménez A, Bordes R, Pineda R, Madrid M. Smoking-related interstitial lung diseases: radiologic-pathologic correlation. Eur Radiol 2006; 16 (11) 2463-2470
    CrossrefPubMedGoogle Scholar
  • 163 Marten K, Hansell DM. Imaging of macrophage-related lung diseases. Eur Radiol 2005; 15 (4) 727-741
    CrossrefPubMedGoogle Scholar
  • 164 Heyneman LE, Ward S, Lynch DA, Remy-Jardin M, Johkoh T, Müller NL. Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?. AJR Am J Roentgenol 1999; 173 (6) 1617-1622
    CrossrefPubMedGoogle Scholar
  • 165 American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991; 144 (5) 1202-1218
    CrossrefPubMedGoogle Scholar
  • 166 Verma H, Nicholson AG, Kerr KM , et al. Alveolar proteinosis with hypersensitivity pneumonitis: a new clinical phenotype. Respirology 2010; 15 (8) 1197-1202
    CrossrefPubMedGoogle Scholar
  • 167 King Jr TE, Behr J, Brown KK , et al. BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008; 177 (1) 75-81
    CrossrefPubMedGoogle Scholar
  • 168 Demedts M, Behr J, Buhl R , et al; IFIGENIA Study Group. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 2005; 353 (21) 2229-2242
    CrossrefPubMedGoogle Scholar
  • 169 Raghu G, Brown KK, Bradford WZ , et al; Idiopathic Pulmonary Fibrosis Study Group. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med 2004; 350 (2) 125-133
    CrossrefPubMedGoogle Scholar
  • 170 Azuma A, Nukiwa T, Tsuboi E , et al. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005; 171 (9) 1040-1047
    CrossrefPubMedGoogle Scholar
  • 171 Taniguchi H, Ebina M, Kondoh Y , et al; Pirfenidone Clinical Study Group in Japan. Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J 2010; 35 (4) 821-829
    CrossrefPubMedGoogle Scholar
  • 172 Tashkin DP, Elashoff R, Clements PJ , et al; Scleroderma Lung Study Research Group. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 2006; 354 (25) 2655-2666
    CrossrefPubMedGoogle Scholar
  • 173 Hoyles RK, Ellis RW, Wellsbury J , et al. A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum 2006; 54 (12) 3962-3970
    CrossrefPubMedGoogle Scholar