Download PDF
Endoskopie heute 2014; 27(1): 37-44
DOI: 10.1055/s-0034-1366071
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Endosonografische Evaluierung von Lunge und Mediastinum

Lung and Mediastinum: Evaluation by Endoscopic Ultrasound
C. Jenssen
1   Klinik für Innere Medizin, Krankenhaus Märkisch Oderland GmbH, Strausberg/Wriezen
,
J. T. Annema
2   Dept. of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam
,
K. Zels
3   Institut für Pathologie, Königs Wusterhausen
,
C. F. Dietrich
4   Medizinische Klinik 2, Caritas Krankenhaus Bad Mergentheim, Bad Mergentheim
› Author Affiliations
Further Information

Publication History

Publication Date:
31 March 2014 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Die hier vorgestellte Arbeit gründet sich auf das Buchkapitel 21 „Mediastinum: Bronchialkarzinom und mediastinale Lymphadenopathien“ im „Kursbuch Endosonografie“ [Herausgeber: Jenssen C, Gottschalk U, Schachschal G, Dietrich CF, Thieme 2014]. Der Artikel ist Teil einer Sequenz von Publikationen, die sich mit bildgebenden Techniken zur Abklärung pneumologischer Fragestellungen auseinandersetzt.

Abstract

The presented update derived from the book chapter 21 „Mediastinum: Lung Cancer and Mediastinal Lymphadenopathy“ of the „Course Book Endosonography“ [Editors: Jenssen C, Gottschalk U, Schachschal G, Dietrich CF, Thieme 2014]. The paper is part of a sequence of articles about imaging techniques for the evaluation of lung diseases.

Schlüsselwörter

Bronchialkarzinom - Leitlinien - Tuberkulose - Sarkoidose - Endosonografie (EUS) - endobronchialer Ultraschall (EBUS)

Key words

lung cancer - guidelines - tuberculosis - sarcoidosis - endoscopic ultrasound (EUS) - endobronchial ultrasound (EBUS)
 

  • Literatur

  • 1 Goeckenjan G, Sitter H, Thomas M et al. Prevention, diagnosis, therapy, and follow-up of lung cancer. Interdisciplinary guideline of the German Respiratory Society and the German Cancer Society – abridged version. Pneumologie 2011; 65: e51-e75
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Dietrich CF, Wehrmann T, Hoffmann C et al. Detection of the adrenal glands by endoscopic or transabdominal ultrasound. Endoscopy 1997; 29: 859-864
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Jenssen C, Dietrich CF. Ultrasound and endoscopic ultrasound of the adrenal glands. Ultraschall in Med 2010; 31: 228-247 quiz 248–250
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Trojan J, Schwarz W, Sarrazin C et al. Role of ultrasonography in the detection of small adrenal masses. Ultraschall in Med 2002; 23: 96-100
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Dietrich CF, Ignee A, Barreiros AP et al. Contrast-enhanced ultrasound for imaging of adrenal masses. Ultraschall in Med 2010; 31: 163-168
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Rusch VW, Asamura H, Watanabe H et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2009; 4: 568-577
    CrossrefPubMedGoogle Scholar
  • 7 Tournoy KG, Annema JT, Krasnik M et al. Endoscopic and endobronchial ultrasonography according to the proposed lymph node map definition in the seventh edition of the tumor, node, metastasis classification for lung cancer. J Thorac Oncol 2009; 4: 1576-1584
    CrossrefPubMedGoogle Scholar
  • 8 Sharma M, Rameshbabu CS, Mohan P. Standard Techniques of Imaging of IASLC Borders by Endoscopic Ultrasound. J Bronchology Interv Pulmonol 2011; 18: 99-110
    CrossrefPubMedGoogle Scholar
  • 9 Dietrich CF, Liesen M, Wehrmann T et al. Mediastinalsonographie, eine neue Bewertung der Befunde. Endoskopie heute 1995; 4: 278-294
    PubMedGoogle Scholar
  • 10 Hirche TO, Wagner TO, Dietrich CF. Mediastinal ultrasound: technique and possible applications. Med Klin (Munich) 2002; 97: 472-479
    CrossrefPubMedGoogle Scholar
  • 11 Tournoy KG, Keller SM, Annema JT. Mediastinal staging of lung cancer: novel concepts. Lancet Oncol 2012; 13: e221-e229
    CrossrefPubMedGoogle Scholar
  • 12 Dietrich CF, Braden B, Wagner TO. Thorax- und Lungensonographie. Dt Ärzteblatt 2000; 97: A103-A110
    PubMedGoogle Scholar
  • 13 Dietrich CF, Hirche TO, Schreiber D et al. Sonographie von Pleura und Lunge. Ultraschall in Med 2003; 24: 303-311
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Adams K, Shah PL, Edmonds L et al. Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis. Thorax 2009; 64: 757-762
    CrossrefPubMedGoogle Scholar
  • 15 Chandra S, Nehra M, Agarwal D et al. Diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle biopsy in mediastinal lymphadenopathy: a systematic review and meta-analysis. Respir Care 2012; 57: 384-391
    PubMedGoogle Scholar
  • 16 Gu P, Zhao YZ, Jiang LY et al. Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer 2009; 45: 1389-1396
    CrossrefPubMedGoogle Scholar
  • 17 Micames CG, McCrory DC, Pavey DA et al. Endoscopic ultrasound-guided fine-needle aspiration for non-small cell lung cancer staging: A systematic review and metaanalysis. Chest 2007; 131: 539-548
    CrossrefPubMedGoogle Scholar
  • 18 Annema JT, Veselic M, Versteegh MI et al. Mediastinal restaging: EUS-FNA offers a new perspective. Lung Cancer 2003; 42: 311-318
    CrossrefPubMedGoogle Scholar
  • 19 Herth FJ, Annema JT, Eberhardt R et al. Endobronchial ultrasound with transbronchial needle aspiration for restaging the mediastinum in lung cancer. J Clin Oncol 2008; 26: 3346-3350
    CrossrefPubMedGoogle Scholar
  • 20 Annema JT, Veselic M, Rabe KF. EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy. Lung Cancer 2005; 48: 357-361 discussion 363–354
    CrossrefPubMedGoogle Scholar
  • 21 Schroder C, Schonhofer B, Vogel B. Transesophageal echographic determination of aortic invasion by lung cancer. Chest 2005; 127: 438-442
    CrossrefPubMedGoogle Scholar
  • 22 Nakajima T, Yasufuku K, Fujiwara T et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions. J Thorac Oncol 2008; 3: 985-988
    CrossrefPubMedGoogle Scholar
  • 23 Tournoy KG, Rintoul RC, van Meerbeeck JP et al. EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy. Lung Cancer 2009; 63: 45-49
    CrossrefPubMedGoogle Scholar
  • 24 Navani N, Brown JM, Nankivell M et al. Suitability of endobronchial ultrasound-guided transbronchial needle aspiration specimens for subtyping and genotyping of non-small cell lung cancer: a multicenter study of 774 patients. Am J Respir Crit Care Med 2012; 185: 1316-1322
    CrossrefPubMedGoogle Scholar
  • 25 Tournoy KG, Carprieaux M, Deschepper E et al. Are EUS-FNA and EBUS-TBNA specimens reliable for subtyping non-small cell lung cancer?. Lung Cancer 2012; 76: 46-50
    CrossrefPubMedGoogle Scholar
  • 26 Kerr KM. Personalized medicine for lung cancer: new challenges for pathology. Histopathology 2012; 60: 531-546
    CrossrefPubMedGoogle Scholar
  • 27 Savic S, Bihl MP, Bubendorf L. Non-small cell lung cancer. Subtyping and predictive molecular marker investigations in cytology. Pathologe 2012; 33: 301-307
    CrossrefPubMedGoogle Scholar
  • 28 Ulivi P, Romagnoli M, Chiadini E et al. Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients. Int J Oncol 2012; 41: 147-152
    PubMedGoogle Scholar
  • 29 Eloubeidi MA, Black KR, Tamhane A et al. A large single-center experience of EUS-guided FNA of the left and right adrenal glands: diagnostic utility and impact on patient management. Gastrointest Endosc 2010; 71: 745-753
    CrossrefPubMedGoogle Scholar
  • 30 Schuurbiers OC, Tournoy KG, Schoppers HJ et al. EUS-FNA for the detection of left adrenal metastasis in patients with lung cancer. Lung Cancer 2011; 73: 310-315
    CrossrefPubMedGoogle Scholar
  • 31 Annema JT, Versteegh MI, Veselic M et al. Endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging. J Clin Oncol 2005; 23: 8357-8361
    CrossrefPubMedGoogle Scholar
  • 32 Tournoy KG, De Ryck F, Vanwalleghem LR et al. Endoscopic ultrasound reduces surgical mediastinal staging in lung cancer: a randomized trial. Am J Respir Crit Care Med 2008; 177: 531-535
    CrossrefPubMedGoogle Scholar
  • 33 Detterbeck FC, Jantz MA, Wallace M et al. Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007; 132: 202S-220S
    CrossrefPubMedGoogle Scholar
  • 34 Annema JT, Versteegh MI, Veselic M et al. Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. JAMA: the journal of the American Medical Association 2005; 294: 931-936
    CrossrefPubMedGoogle Scholar
  • 35 Annema JT, van Meerbeeck JP, Rintoul RC et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA: the journal of the American Medical Association 2010; 304: 2245-2252
    CrossrefPubMedGoogle Scholar
  • 36 Herth FJ, Krasnik M, Kahn N et al. Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer. Chest 2010; 138: 790-794
    CrossrefPubMedGoogle Scholar
  • 37 Wallace MB, Pascual JM, Raimondo M et al. Minimally invasive endoscopic staging of suspected lung cancer. JAMA: the journal of the American Medical Association 2008; 299: 540-546
    CrossrefPubMedGoogle Scholar
  • 38 Hwangbo B, Lee GK, Lee HS et al. Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer. Chest 2010; 138: 795-802
    CrossrefPubMedGoogle Scholar
  • 39 Wallace MB, Ravenel J, Block MI et al. Endoscopic ultrasound in lung cancer patients with a normal mediastinum on computed tomography. Ann Thorac Surg 2004; 77: 1763-1768
    CrossrefPubMedGoogle Scholar
  • 40 Fernandez-Esparrach G, Gines A, Belda J et al. Transesophageal ultrasound-guided fine needle aspiration improves mediastinal staging in patients with non-small cell lung cancer and normal mediastinum on computed tomography. Lung Cancer 2006; 54: 35-40
    CrossrefPubMedGoogle Scholar
  • 41 Herth FJ, Eberhardt R, Krasnik M et al. Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically and positron emission tomography-normal mediastinum in patients with lung cancer. Chest 2008; 133: 887-891
    CrossrefPubMedGoogle Scholar
  • 42 Prosch H, Strasser G, Sonka C et al. Cervical ultrasound (US) and US-guided lymph node biopsy as a routine procedure for staging of lung cancer. Ultraschall in Med 2007; 28: 598-603
    Article in Thieme ConnectPubMedGoogle Scholar
  • 43 Schmulewitz N, Wildi SM, Varadarajulu S et al. Accuracy of EUS criteria and primary tumor site for identification of mediastinal lymph node metastasis from non-small-cell lung cancer. Gastrointest Endosc 2004; 59: 205-212
    CrossrefPubMedGoogle Scholar
  • 44 Janssen J, Dietrich CF, Will U et al. Endosonographic elastography in the diagnosis of mediastinal lymph nodes. Endoscopy 2007; 39: 952-957
    Article in Thieme ConnectPubMedGoogle Scholar
  • 45 Zhang R, Ying K, Shi L et al. Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal lymph node staging of lung cancer: a meta-analysis. European journal of cancer 2013; 49: 1860-1867
    CrossrefPubMedGoogle Scholar
  • 46 Kang HJ, Hwangbo B, Lee GK et al. EBUS-centred versus EUS-centred mediastinal staging in lung cancer: a randomised controlled trial. Thorax 2013; DOI: 10.1136/thoraxjnl-2013-203881.
    PubMedGoogle Scholar
  • 47 Annema JT. Complete endosonographic staging of lung cancer. Thorax 2014; DOI: 10.1136/thoraxjnl-2013-204906.
    PubMedGoogle Scholar
  • 48 Jenssen C, Alvarez-Sánchez MV, Napoléon B et al. Diagnostic Endoscopic Ultrasonography: Assessment of Safety and Prevention of Complications. World J Gastroenterol 2012; 18: 4659-4676
    CrossrefPubMedGoogle Scholar
  • 49 Tournoy KG, Burgers SA, Annema JT et al. Transesophageal endoscopic ultrasound with fine needle aspiration in the preoperative staging of malignant pleural mesothelioma. Clin Cancer Res 2008; 14: 6259-6263
    CrossrefPubMedGoogle Scholar
  • 50 Jenssen C, Siebert C, Gottschalk U. The role of endoscopic ultrasound in M-staging of gastrointestinal and pancreaticobiliary cancer. Video Journal & Encyclopedia GI Endoscopy 2013; 1: 105-109
    PubMedGoogle Scholar
  • 51 Tournoy KG, Govaerts E, Malfait T et al. Endobronchial ultrasound-guided transbronchial needle biopsy for M1 staging of extrathoracic malignancies. Ann Oncol 2011; 22: 127-131
    CrossrefPubMedGoogle Scholar
  • 52 Navani N, Nankivell M, Woolhouse I et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study. J Thorac Oncol 2011; 6: 1505-1509
    CrossrefPubMedGoogle Scholar
  • 53 Peric R, Schuurbiers OC, Veselic M et al. Transesophageal endoscopic ultrasound-guided fine-needle aspiration for the mediastinal staging of extrathoracic tumors: a new perspective. Ann Oncol 2010; 21: 1468-1471
    CrossrefPubMedGoogle Scholar
  • 54 Fritscher-Ravens A, Sriram PV, Bobrowski C et al. Mediastinal lymphadenopathy in patients with or without previous malignancy: EUS-FNA-based differential cytodiagnosis in 153 patients. Am J Gastroenterol 2000; 95: 2278-2284
    CrossrefPubMedGoogle Scholar
  • 55 Jenssen C, Möller K, Sarbia M et al. Endoscopic ultrasound-guided biopsy – indications, problems, pitfalls, troubleshooting, clinical impact. In: Dietrich CF, Hrsg. Endoscopic ultrasound – an introductory manual and atlas. Stuttgart, New York: Thieme; 2011
    Article in Thieme ConnectGoogle Scholar
  • 56 Yasuda I, Goto N, Tsurumi H et al. Endoscopic ultrasound-guided fine needle aspiration biopsy for diagnosis of lymphoproliferative disorders: feasibility of immunohistological, flow cytometric, and cytogenetic assessments. Am J Gastroenterol 2012; 107: 397-404
    CrossrefPubMedGoogle Scholar
  • 57 von Bartheld MB, Veselic-Charvat M, Rabe KF et al. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis. Endoscopy 2010; 42: 213-217
    Article in Thieme ConnectPubMedGoogle Scholar
  • 58 Agarwal R, Srinivasan A, Aggarwal AN et al. Efficacy and safety of convex probe EBUS-TBNA in sarcoidosis: a systematic review and meta-analysis. Respir Med 2012; 106: 883-892
    CrossrefPubMedGoogle Scholar
  • 59 Navani N, Booth HL, Kocjan G et al. Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis. Respirology 2011; 16: 467-472
    CrossrefPubMedGoogle Scholar
  • 60 von Bartheld MB, Dekkers OM, Szlubowski A et al. Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA: the journal of the American Medical Association 2013; 309: 2457-2464
    CrossrefPubMedGoogle Scholar
  • 61 von Bartheld M, van der Heijden E, Annema J. Mediastinal abscess formation after EUS-guided FNA: are patients with sarcoidosis at increased risk?. Gastrointest Endosc 2012; 75: 1104-1107
    CrossrefPubMedGoogle Scholar
  • 62 Fritscher-Ravens A, Ghanbari A, Topalidis T et al. Granulomatous mediastinal adenopathy: can endoscopic ultrasound-guided fine-needle aspiration differentiate between tuberculosis and sarcoidosis?. Endoscopy 2011; 43: 955-961
    Article in Thieme ConnectPubMedGoogle Scholar
  • 63 Navani N, Molyneaux PL, Breen RA et al. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax 2011; 66: 889-893
    CrossrefPubMedGoogle Scholar
  • 64 Kennedy MP, Jimenez CA, Mhatre AD et al. Clinical implications of granulomatous inflammation detected by endobronchial ultrasound transbronchial needle aspiration in patients with suspected cancer recurrence in the mediastinum. J Cardiothorac Surg 2008; 3: 8
    CrossrefPubMedGoogle Scholar
  • 65 Depew ZS, Gonsalves WI, Roden AC et al. Granulomatous Inflammation Detected by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Patients With a Concurrent Diagnosis of Cancer: A Clinical Conundrum. J Bronchology Interv Pulmonol 2012; 19: 176-181
    CrossrefPubMedGoogle Scholar
  • 66 Konge L, Vilmann P, Clementsen P et al. Reliable and valid assessment of competence in endoscopic ultrasonography and fine-needle aspiration for mediastinal staging of non-small cell lung cancer. Endoscopy 2012; 44: 928-933
    Article in Thieme ConnectPubMedGoogle Scholar