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Thorac Cardiovasc Surg 2014; 62(07): 588-592
DOI: 10.1055/s-0034-1367733
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

Results of Surgical Treatment for Non-Small Cell Lung Cancer with Positive Sputum Cytology: Experience from a Single Institution

Yoshiki Kozu
1   Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
,
Tomohiro Maniwa
1   Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
,
Shoji Takahashi
1   Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
,
Mitsuhiro Isaka
1   Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
,
Yasuhisa Ohde
1   Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan
› Author Affiliations
Further Information

Publication History

26 August 2013

07 December 2013

Publication Date:
03 March 2014 (online)

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Abstract

Background Little is known about the prognostic value of positive sputum cytology in patients with non-small cell lung cancer (NSCLC).

Patients and Methods We retrospectively examined the clinicopathological data of 30 patients who had undergone complete resection for NSCLC with positive sputum cytology between September 2002 and June 2011.

Results Distant recurrence occurred significantly more frequently in the patients with adenocarcinoma (Ad) than in those with squamous cell carcinoma (p = 0.01). The most frequent metastatic site after surgery was the brain, occurring in five patients with Ad. The 5-year disease-free survival (DFS) and overall survival (OS) rates of the 30 patients were 53 and 49%, respectively. In multivariate analyses, radiographic feature of pneumonic-type shadow and pathological N (pN) 1–2 status were the independent factors significantly correlated with poor DFS (p = 0.009, 0.001, respectively), whereas pN 1–2 status was the only independent factor significantly correlated with poor OS (p = 0.009).

Conclusion Surgical outcome for NSCLC with positive sputum cytology was unfavorable at our institution. Close surveillance after a curative resection is mandatory for those patients presenting with radiographic feature of pneumonic-type shadow as those with lymph node metastases because they are at high risk for recurrence.

Keywords

sputum cytology - non-small cell lung cancer - surgical treatment - pneumonic-type shadow
 

  • References

  • 1 Bechtel JJ, Petty TL, Saccomanno G. Five year survival and later outcome of patients with X-ray occult lung cancer detected by sputum cytology. Lung Cancer 2000; 30 (1) 1-7
    CrossrefPubMedGoogle Scholar
  • 2 Saito Y, Nagamoto N, Ota S , et al. Results of surgical treatment for roentgenographically occult bronchogenic squamous cell carcinoma. J Thorac Cardiovasc Surg 1992; 104 (2) 401-407
    PubMedGoogle Scholar
  • 3 Cortese DA, Pairolero PC, Bergstralh EJ , et al. Roentgenographically occult lung cancer. A ten-year experience. J Thorac Cardiovasc Surg 1983; 86 (3) 373-380
    PubMedGoogle Scholar
  • 4 Cortese DA. The prognostic value of sputum cytology. Chest 1992; 102 (5) 1315-1316
    CrossrefPubMedGoogle Scholar
  • 5 Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC. World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. Lyon, France: IARC Press; 2004
    Google Scholar
  • 6 Sobin LH, Gospodarowicz MK, Wittekind C. UICC. TNM Classification of Malignant Tumours. 7th ed. Wiley-Blackwell: Oxford; 2009
    Google Scholar
  • 7 Wislez M, Massiani MA, Milleron B , et al. Clinical characteristics of pneumonic-type adenocarcinoma of the lung. Chest 2003; 123 (6) 1868-1877
    CrossrefPubMedGoogle Scholar