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Planta Med 2014; 80(06): 490-492
DOI: 10.1055/s-0034-1368298
Biological and Pharmacological Activity
Letters
Georg Thieme Verlag KG Stuttgart · New York

Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin

Pollyanna Francielli de Oliveira
1   Universidade de Franca, Franca, São Paulo, Brazil
,
Ildercílio Mota de Souza Lima
1   Universidade de Franca, Franca, São Paulo, Brazil
,
Carla Carolina Munari
1   Universidade de Franca, Franca, São Paulo, Brazil
,
Jairo Kenupp Bastos
2   Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
,
Ademar Alves da Silva Filho
3   Faculdade de Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil
,
Denise Crispim Tavares
1   Universidade de Franca, Franca, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

received 29 November 2013
revised 20 February 2014

accepted 24 February 2014

Publication Date:
31 March 2014 (online)

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Abstract

This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 ± 4.5 µg/mL for U343 and 44.9 ± 7.1 µg/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 ± 2.9 for U343 and 13.0 ± 1.5 µg/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 ± 0.5 µg/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.

Key words

green propolis - Baccharis dracunculifolia - Asteraceae - artepillin C - baccharin

Supporting Information

 

  • References

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