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Planta Med 2014; 80(08/09): 671-675
DOI: 10.1055/s-0034-1368592
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Structure-Activity Relationship Study of Dibenzocyclooctadiene Lignans Isolated from Schisandra chinensis on Lipopolysaccharide-Induced Microglia Activation

Di Hu
1   Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China
2   College of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
,
Na Han
1   Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China
,
Xuechun Yao
3   Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
,
Zhihui Liu
1   Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China
,
Yu Wang
4   The Chinese Peopleʼs Liberation Army 463 Hospital, Shenyang, China
,
Jingyu Yang
3   Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
,
Jun Yin
1   Development and Utilization Key Laboratory of Northeast Plant Materials of Liaoning Province, Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, China
› Author Affiliations
Further Information

Publication History

received 22 January 2014
revised 07 May 2014

accepted 20 May 2014

Publication Date:
25 June 2014 (online)

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Abstract

To explore the relationship of the dibenzocyclooctadiene lignans from Schisandra chinensis to their anti-inflammatory activities, series of dibenzocyclooctadiene lignans were isolated and assessed by testing their inhibitory effects on nitric oxide production in lipopolysaccharide-induced BV2 mouse microglia. It was found, for the first time, that dibenzocyclooctadiene lignans which have S-biphenyl and methylenedioxy groups strongly inhibited LPS-induced microglia activation. The methoxy group on the cyclooctadiene introduced more effectiveness, but the presence of an acetyl group on the cyclooctadiene or hydroxyl group on C-7 decreased the inhibitory activity.

Key words

Schisandra chinensis - Schisandraceae - dibenzocyclooctadiene lignans - microglia - nitric oxide - structure-activity relationship

Supporting Information

 

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