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Aktuelle Neurologie 2014; 41(04): 208-216
DOI: 10.1055/s-0034-1370029
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Theory of Mind, Prosodieerkennung und Empathie bei sekundär progredienter Multipler Sklerose[*]

Theory of Mind, Perception of Affective Prosody and Empathy in Secondary Progressive Multiple Sclerosis
M. Krämer
1   Klinik für Neurologie, Alfried Krupp-Krankenhaus Essen
,
S. Brauner
1   Klinik für Neurologie, Alfried Krupp-Krankenhaus Essen
,
M. Herold
2   Klinik und Poliklinik für Psychiatrie und Psychotherapie des Klinikums rechts der Isar, München
,
R. R. Diehl
1   Klinik für Neurologie, Alfried Krupp-Krankenhaus Essen
,
I. Dziobek
3   Freie Universität Berlin, Arbeitsbereich Emotionspsychologie und affektive Neurowissenschaft, Cluster Languages of Emotion, Berlin
,
P. Berlit
1   Klinik für Neurologie, Alfried Krupp-Krankenhaus Essen
› Author Affiliations
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Publication History

Publication Date:
16 May 2014 (online)

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Zusammenfassung

Während Defizite der Aufmerksamkeit, des Gedächtnisses und der Exekutivfunktionen bei Multipler Sklerose (MS) breit beschrieben sind, gibt es wenige Daten zur sozialen Kognition bei MS. Als soziale Kognition bezeichnet man die neuropsychologischen Fähigkeiten der Theory of Mind, der Gesichter- und Prosodieerkennung und der Empathie. Vorherige Studien hatten oft nicht zwischen verschiedenen Schweregraden und Verlaufsformen der MS unterschieden. Nachdem wir bereits in frühen Stadien der schubförmigen MS Defizite der sozialen Kognition zeigen konnten, wurden nun 25 Patienten mit sekundär chronisch progredienter MS mit 25 Kontrollen verglichen. Eine dezidierte Testbatterie der sozialen Kognition wurde angewandt. Es ließen sich breite Defizite der Prosodieerkennung und der Theory of Mind sowie der Exekutivfunktionen feststellen, die Empathie wurde in der Selbsteinschätzung als nicht eingeschränkt angegeben. Konsequenzen dieser Defizite für den Alltag des Patienten und die Arzt-Patienten-Beziehung werden diskutiert.

Abstract

Despite extensive knowledge on cognitive impairment in multiple sclerosis, little is known concerning social cognition in secondary progressive MS (SPMS). Social cognition is defined as the neuropsychological abilities of Theory of Mind, perception of face and prosody, and empathy. Earlier studies have failed to distinguish between different grades of severity and different courses the diseases run. We have previously shown that already in the early stages of relapsing remitted MS, mild deficits of social cognition can be identified. In the present study, 25 patients with SPMS were tested regarding their theory of mind, perception of affective prosody and facial expressions, and empathy and were compared to 25 healthy controls. Significant deficits in perception of affective prosody and facial expression, theory of mind and executive functions were found. According to self-reports, empathy was described as being unimpaired. Deficits in social cognition negatively influence daily life of patients and interaction between neurologists and patients.

Schlüsselwörter

soziale Kognition - Theory of Mind - Prosodieerkennung - Empathie - Multiple Sklerose

Keywords

social cognition - theory of mind - perception of affective prosody - empathy - multiple sclerosis

* Konzeption, Design und einige Inhalte dieser Studie überschneiden sich mit der Vorläuferstudie zur schubförmigen MS, die in Form einer Dissertation und zweier wissenschaftlicher Artikel veröffentlicht wurde [2] [3] [4].


 

  • Literatur

  • 1 Fiske S. Social beings: A core motive approach to social psychology. New York: Wiley; 2004
    Google Scholar
  • 2 Herold M. Empathie, Theory of Mind und Prosodieerkennung in frühen Stadien der Multiplen Sklerose. Dissertation. Essen: Universität Duisburg-Essen; 2012
    Google Scholar
  • 3 Kraemer M, Herold M, Uekermann J et al. Perception of affective prosody in patients at an early stage of relapsing-remitting multiple sclerosis. J Neuropsychol 2013; 7: 91-106
    CrossrefPubMedGoogle Scholar
  • 4 Kraemer M, Herold M, Uekermann J et al. Theory of mind and empathy in patients at an early stage of relapsing remitting multiple sclerosis. Clin Neurol Neurosurg 2013; 115: 1016-1022
    CrossrefPubMedGoogle Scholar
  • 5 Premack D, Woodruff G. Does the chimpanzee have theory of mind?. Behav Brain Sci 1978; 515-526
    PubMedGoogle Scholar
  • 6 Rowe AD, Bullock PR, Polkey CE et al. “Theory of mind” impairments and their relationship to executive functioning following frontal lobe excisions. Brain 2001; 124: 600-616
    CrossrefPubMedGoogle Scholar
  • 7 Uekermann J, Channon S, Winkel K et al. Theory of mind, humour processing and executive functioning in alcoholism. Addiction 2007; 102: 232-420
    CrossrefPubMedGoogle Scholar
  • 8 Shamay-Tsoory S, Harari H, Szepsenwol O et al. Neuropsychological evidence of impaired cognitive empathy in euthymic bipolar disorder. J Neuropsychiatry Clin Neurosci 2009; 21: 59-67
    CrossrefPubMedGoogle Scholar
  • 9 Shamay-Tsoory SG, Aharon-Peretz J, Perry D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 2009; 132: 617-627
    CrossrefPubMedGoogle Scholar
  • 10 Vollm BA, Taylor AN, Richardson P et al. Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 2006; 29: 90-98
    CrossrefPubMedGoogle Scholar
  • 11 Ross ED. Cortical Representation of Emotions. Contemporary Behavioral Neurology 1997; 107-126
    PubMedGoogle Scholar
  • 12 Uekermann J, Kraemer M, Abdel-Hamid M et al. Social cognition in attention-deficit hyperactivity disorder (ADHD). Neurosci Biobehav Rev 2010; 34: 734-743
    CrossrefPubMedGoogle Scholar
  • 13 Rao SM, Leo GJ, Ellington L et al. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 1991; 41: 692-696
    CrossrefPubMedGoogle Scholar
  • 14 Benito-Leon J, Morales JM, Rivera-Navarro J. Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients. Eur J Neurol 2002; 9: 497-502
    CrossrefPubMedGoogle Scholar
  • 15 Sartori E, Belliard S, Chevrier C et al. [From psychometry to neuropsychological disability in multiple sclerosis: a new brief French cognitive screening battery and cognitive risk factors]. Rev Neurol (Paris) 2006; 162: 603-615
    CrossrefPubMedGoogle Scholar
  • 16 Winkelmann A, Engel C, Apel A et al. Cognitive impairment in multiple sclerosis. J Neurol 2007; 254 (Suppl. 02) II35-42
    PubMedGoogle Scholar
  • 17 Demaree HA, Gaudino EA, DeLuca J et al. Learning impairment is associated with recall ability in multiple sclerosis. J Clin Exp Neuropsychol 2000; 22: 865-873
    CrossrefPubMedGoogle Scholar
  • 18 Huijbregts SC, Kalkers NF, de Sonneville LM et al. Cognitive impairment and decline in different MS subtypes. J Neurol Sci 2006; 245: 187-194
    CrossrefPubMedGoogle Scholar
  • 19 Deloire MS, Bonnet MC, Salort E et al. How to detect cognitive dysfunction at early stages of multiple sclerosis?. Mult Scler 2006; 12: 445-452
    CrossrefPubMedGoogle Scholar
  • 20 Beatty WW, Orbelo DM, Sorocco KH et al. Comprehension of affective prosody in multiple sclerosis. Mult Scler 2003; 9: 148-153
    CrossrefPubMedGoogle Scholar
  • 21 Baron-Cohen S, Wheelwright S, Hill J et al. The „Reading the Mind in the Eyes“ test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001; 42: 241-251
    CrossrefPubMedGoogle Scholar
  • 22 Banati M, Sandor J, Mike A et al. Social cognition and Theory of Mind in patients with relapsing-remitting multiple sclerosis. Eur J Neurol 2010; 17: 426-433
    CrossrefPubMedGoogle Scholar
  • 23 Krause M, Wendt J, Dressel A et al. Prefrontal function associated with impaired emotion recognition in patients with multiple sclerosis. Behav Brain Res 2009; 205: 280-285
    CrossrefPubMedGoogle Scholar
  • 24 Ouellet J, Scherzer PB, Rouleau I et al. Assessment of social cognition in patients with multiple sclerosis. J Int Neuropsychol Soc 2010; 16: 287-296
    CrossrefPubMedGoogle Scholar
  • 25 Jehna M, Neuper C, Petrovic K et al. An exploratory study on emotion recognition in patients with a clinically isolated syndrome and multiple sclerosis. Clin Neurol Neurosurg 2010; 112: 482-484
    CrossrefPubMedGoogle Scholar
  • 26 Krause L, Enticott PG, Zangen A et al. The role of medial prefrontal cortex in theory of mind: A deep rTMS study. Behav Brain Res 2012; 228: 87-90
    CrossrefPubMedGoogle Scholar
  • 27 Kurtzke JF. Rating Neurologic Impairment in Multiple Sclerosis: An expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452
    CrossrefPubMedGoogle Scholar
  • 28 Beck AT, Ward CH, Mendelson M et al. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571
    CrossrefPubMedGoogle Scholar
  • 29 Hautzinger M, Bailer M, Worall H et al. BDI Beck-Depressions-Inventar. Testhandbuch 2.. überarbeitete Auflage. Bern: Verlag Hans Huber; 1995
    Google Scholar
  • 30 Wechsler D. Wechsler Adult Intelligence Scale – III. San Antonio: The Psychological Corporation; 1997
    Google Scholar
  • 31 Dahl G. Reduzierter Wechsler Intelligenztest (Short version of the Wechsler intelligence test). Hain: Meisenheim; 1986
    Google Scholar
  • 32 Bäumler G. Farb-Wort-Interferenztest (FWIT) nach J. R. Stroop. Göttingen: Hogrefe; 1985
    Google Scholar
  • 33 Reitan RM. Trail Making Test: Manual for Administration and Scoring. Reitan Neuropsychology Laboratory; 1992. 2.. Ed.: 1-9
    Google Scholar
  • 34 Dziobek I, Fleck S, Kalbe E et al. Introducing MASC: a movie for the assessment of social cognition. J Autism Dev Disord 2006; 36: 623-636
    CrossrefPubMedGoogle Scholar
  • 35 Baron-Cohen S, Wheelwright S. The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord 2004; 34: 163-175
    CrossrefPubMedGoogle Scholar
  • 36 Breitenstein C, Daum I, Ackermann H et al. Assessment of deficits in emotional perception following cortical and subcortical brain damage: Psychometric properties of the „Tubingen Affect Battery“. Neurol Rehabilitation 1996; 2: 93-101
    PubMedGoogle Scholar
  • 37 Bowers D, Blonder L, Heilman K. The Florida affect battery. Center of Neuropsychological Studies; 1992
    Google Scholar
  • 38 Kraemer M, Herold M, Uekermann J et al. Perception of affective prosody in patients at an early stage of relapsing remitting multiple sclerosis. submitted 2011
    PubMedGoogle Scholar