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Semin Musculoskelet Radiol 2014; 18(02): 149-165
DOI: 10.1055/s-0034-1371017
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Role of PET/CT in the Evaluation of Skeletal Metastases

Anbalagan Kannivelu
1   Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore, Singapore
2   Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore
,
Kelvin S.H. Loke
2   Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore
,
Tian Yue Kok
2   Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore
,
Saabry Yusof Osmany
3   Radlink PET and Cardiac Imaging Pte Ltd, Singapore, Singapore
,
Syed Zama Ali
1   Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore, Singapore
2   Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore
,
Lu Suat-Jin
4   Nuclear Medicine and PET Centre, Mount Elizabeth Hospital, Singapore, Singapore
,
David Chee-Eng Ng
2   Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore, Singapore
› Author Affiliations
Further Information

Publication History

Publication Date:
08 April 2014 (online)

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Abstract

Osseous metastatic disease from malignancy is a common occurrence with significant patient morbidity and mortality as well as increasing health care expenditures. Patient management plans frequently change with the identification of skeletal metastasis and the upstaging of disease status. Bone scintigraphy remains the current mainstay of diagnostic imaging procedures in nuclear medicine for the early detection of skeletal metastasis owing to their high sensitivity. Emerging positron tracers and the increasing use and availability of hybrid single-photon emission computed tomography and positron emission tomography (PET)/computed tomography machines enable physicians to diagnose metastatic disease in bones with superior accuracy. This review introduces the basics of PET and the commonly used positron tracers used to evaluate skeletal metastases.

Keywords

skeletal metastases - [18F]-FDG PET - [18F]-NaF PET - Tc-99m diphosphonate bone scan - skeletal scintigraphy - hybrid imaging - image fusion
 

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