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J Neurol Surg A Cent Eur Neurosurg 2015; 76(02): 144-148
DOI: 10.1055/s-0034-1371514
Review

Management and Prognosis of Primary Cerebral Melanocytic Tumors. A Case Report and Systematic Review

Bruno Splavski
1   Department of Neurosurgery, Osijek Clinical Hospital Centre, Osijek, Croatia
,
Dario Muzevic
1   Department of Neurosurgery, Osijek Clinical Hospital Centre, Osijek, Croatia
,
Marko Kovacevic
1   Department of Neurosurgery, Osijek Clinical Hospital Centre, Osijek, Croatia
,
Brano Splavski Jr.
2   Division of Ophthalmology, Osijek Clinical Hospital Centre, Osijek, Croatia
,
Goran Bajek
3   Department of Neurosurgery, Rijeka Clinical Hospital Centre, Rijeka, Croatia
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Abstract

Primary melanocytic cerebral tumors form a spectrum of different lesions that range from benign to extremely malignant, such as an intracranial melanoma. This article points out some characteristics of primary melanocytic cerebral tumors and discusses their management and prognosis, based on a systematic literature review and a case of primary cerebral malignant melanoma.

Because the biological characteristics of primary melanocytic cerebral tumors remain unclear, it appears that total surgical resection of the tumor followed by oncologic treatment is the mainstay of the management. The prognosis still depends on the degree of malignancy.

Keywords

primary melanocytic cerebral tumor - management protocol - prognosis - systematic review


Publication History

Received: 17 April 2013

Accepted: 03 January 2014

Publication Date:
21 July 2014 (online)

© 2014. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

  • References

  • 1 Brat DJ, Perry A. Melanocytic lesions. In: Louis DN, Ohaki H, Wiestler OD, Cavenee WK. , eds. WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon, France: IARC Press; 2007: 181-183
    Google Scholar
  • 2 Isiklar I, Leeds NE, Fuller GN, Kumar AJ. Intracranial metastatic melanoma: correlation between MR imaging characteristics and melanin content. AJR Am J Roentgenol 1995; 165 (06) 1503-1512
    CrossrefPubMedGoogle Scholar
  • 3 Greco Crasto S, Soffietti R, Bradac GB, Boldorini R. Primitive cerebral melanoma: case report and review of the literature. Surg Neurol 2001; 55 (03) 163-168 ; discussion 168
    CrossrefPubMedGoogle Scholar
  • 4 Liubinas SV, Maartens N, Drummond KJ. Primary melanocytic neoplasms of the central nervous system. J Clin Neurosci 2010; 17 (10) 1227-1232
    CrossrefPubMedGoogle Scholar
  • 5 Bhandari L, Alapatt J, Govindan A, Sreekumar T. Primary cerebellopontine angle melanoma: a case report and review. Turk Neurosurg 2012; 22 (04) 469-474
    PubMedGoogle Scholar
  • 6 Jaiswal S, Vij M, Tungria A, Jaiswal AK, Srivastava AK, Behari S. Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. Neurol India 2011; 59 (03) 413-419
    CrossrefPubMedGoogle Scholar
  • 7 Gempt J, Buchmann N, Grams AE. , et al. Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. J Neurooncol 2011; 102 (02) 323-328
    CrossrefPubMedGoogle Scholar
  • 8 Navas M, Pascual JM, Fraga J. , et al. Intracranial intermediate-grade meningeal melanocytoma with increased cellular proliferative index: an illustrative case associated with a nevus of Ota. J Neurooncol 2009; 95 (01) 105-115
    CrossrefPubMedGoogle Scholar
  • 9 Freudenstein D, Wagner A, Bornemann A, Ernemann U, Bauer T, Duffner F. Primary melanocytic lesions of the CNS: report of five cases. Zentralbl Neurochir 2004; 65 (03) 146-153
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Rosenthal G, Gomori JM, Tobias S, Diment J, Shoshan Y. Unusual cases involving the CNS and nasal sinuses: Case 1. Primary leptomeningeal melanoma. J Clin Oncol 2003; 21 (20) 3875-3877
    CrossrefPubMedGoogle Scholar
  • 11 Pirini MG, Mascalchi M, Salvi F. , et al. Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. AJNR Am J Neuroradiol 2003; 24 (01) 115-118
    PubMedGoogle Scholar
  • 12 Whinney D, Kitchen N, Revesz T, Brookes G. Primary malignant melanoma of the cerebellopontine angle. Otol Neurotol 2001; 22 (02) 218-222
    CrossrefPubMedGoogle Scholar
  • 13 Amarti A, Bernoussi Z, Aghzadi A, Khamlichi A, Saidi A. Intracranial malignant melanoma. Report of 4 cases [in French]. Arch Anat Cytol Pathol 1998; 46 (03) 188-192
    PubMedGoogle Scholar
  • 14 Fish LA, Friedman DI, Sadun AA. Progressive cranial polyneuropathy caused by primary central nervous system melanoma. J Clin Neuroophthalmol 1990; 10 (01) 41-44
    PubMedGoogle Scholar
  • 15 Braga FM, Tella Júnior OI, Ferreira A, Jordy CF. Malignant melanoma of the cerebello-pontine angle region. Arq Neuropsiquiatr 1989; 47 (04) 496-500
    CrossrefPubMedGoogle Scholar
  • 16 Golubicić I, Sobić V, Vlajić M, Barjaktarević Z. Intracranial malignant melanoma in childhood [in Serbian]. Srp Arh Celok Lek 1989; 117 (11/12) 855-862
    PubMedGoogle Scholar
  • 17 Brat DJ, Giannini C, Scheithauer BW, Burger PC. Primary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol 1999; 23 (07) 745-754
    CrossrefPubMedGoogle Scholar
  • 18 Salame K, Merimsky O, Yosipov J, Reider-Groswasser I, Chaitchik S, Ouaknine GE. Primary intramedullary spinal melanoma: diagnostic and treatment problems. J Neurooncol 1998; 36 (01) 79-83
    CrossrefPubMedGoogle Scholar
  • 19 Painter TJ, Chaljub G, Sethi R, Singh H, Gelman B. Intracranial and intraspinal meningeal melanocytosis. AJNR Am J Neuroradiol 2000; 21 (07) 1349-1353
    PubMedGoogle Scholar
  • 20 Czarnecki EJ, Silbergleit R, Gutierrez JA. MR of spinal meningeal melanocytoma. AJNR Am J Neuroradiol 1997; 18 (01) 180-182
    PubMedGoogle Scholar
  • 21 Kashiwagi N, Hirabuki N, Morino H, Taki T, Yoshida W, Nakamura H. Primary solitary intracranial melanoma in the sylvian fissure: MR demonstration. Eur Radiol 2002; 12 (Suppl. 03) S7-S10
    CrossrefPubMedGoogle Scholar