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Int J Angiol 2016; 25(05): e12-e13
DOI: 10.1055/s-0034-1371760
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Plausible Role of Acute HIV Infection Mediated Immune Activation in Causing Renal Allograft Rejection: A Case Report

Vivek Jayaschandran
1   Department of Transplant Program, North Shore University Hospital, New York
,
Prejith P. Rajendran
1   Department of Transplant Program, North Shore University Hospital, New York
,
Mamata Khanal
1   Department of Transplant Program, North Shore University Hospital, New York
,
Prathik Krishnan
1   Department of Transplant Program, North Shore University Hospital, New York
,
Poornima Ramadas
1   Department of Transplant Program, North Shore University Hospital, New York
,
Asha Alex
1   Department of Transplant Program, North Shore University Hospital, New York
,
Lakshmi Nambiar
1   Department of Transplant Program, North Shore University Hospital, New York
,
David A. Hirschwerk
2   Department of Infectious Disease Medicine, North Shore University Hospital, New York
,
Joseph P. McGowan
2   Department of Infectious Disease Medicine, North Shore University Hospital, New York
,
Nicole Ali
1   Department of Transplant Program, North Shore University Hospital, New York
,
Amit Basu
1   Department of Transplant Program, North Shore University Hospital, New York
,
Madhu Bhaskaran
1   Department of Transplant Program, North Shore University Hospital, New York
,
Ernesto P. Molmenti
1   Department of Transplant Program, North Shore University Hospital, New York
› Author Affiliations
Further Information

Publication History

Publication Date:
02 December 2014 (online)

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Abstract

Current research states that AIDS pathogenesis has its roots in a chronic activation of immune system secondary to human immunodeficiency virus (HIV)–induced proliferation of T cells, B cells, NK cells, and macrophages. Immune activation due to acute HIV infection can be highly detrimental to allograft survival in a renal transplant recipient. In this report, we describe a 32-year-old African-American male patient who underwent a second live donor renal transplant, following which he developed acute allograft rejection coincident with newly acquired HIV seropositivity.

Keywords

allograft - HIV - immunosuppression - AIDS - renal transplant
 

  • References

  • 1 Sodora DL, Silvestri G. Immune activation and AIDS pathogenesis. AIDS 2008; 22 (4) 439-446
    CrossrefPubMedSearch in Google Scholar
  • 2 Hazenberg MD, Otto SA, van Benthem BH , et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003; 17 (13) 1881-1888
    CrossrefPubMedSearch in Google Scholar
  • 3 Ascher MS, Sheppard HW. AIDS as immune system activation: a model for pathogenesis. Clin Exp Immunol 1988; 73 (2) 165-167
    PubMedSearch in Google Scholar
  • 4 Hazenberg MD, Stuart JWC, Otto SA , et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000; 95 (1) 249-255
    CrossrefPubMedSearch in Google Scholar