Intensivmedizin up2date, Table of Contents Intensivmedizin up2date 2014; 10(04): 301-316DOI: 10.1055/s-0034-1378071 Internistische Intensivmedizin © Georg Thieme Verlag KG Stuttgart · New York Update Postreanimationserkrankung – neue Evidenz und Rolle der Inflammation Katrin Fink , Hans-Jörg Busch , Tobias Wengenmayer Recommend Article Abstract Buy Article All articles of this category Full Text References Literatur 1 Berdowski J, Berg RA, Tijssen JGP et al. Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies. Resuscitation 2010; 81: 1479-1487 2 Peberdy MA, Callaway CW, Neumar RW et al. Part 9: Post-Cardiac Arrest Care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010; 122: 768-786 3 Busch HJ. Selenium substitution after cardiac arrest. Dtsch Med Wochensch 2009; 134 (Suppl. 11) 419-421 4 Tagami T, Hirata K, Takeshige T et al. Implementation of the fifth link of the chain of survival concept for out-of-hospital cardiac arrest. Circulation 2012; 126: 589-597 5 Roberts BW, Kilgannon JH, Mitchell JA et al. Emergency department inter-hospital transfer for post-cardiac arrest care: initial experience with implementation of a regional cardiac resuscitation center in the United States. Resuscitation 2013; 84: 596-601 6 Negovsky VA. Postresuscitation disease. Crit Care Med 1988; 16: 942-946 7 Adrie C, Adib-Conquy M, Laurent I et al. Successful cardiopulmonary resuscitation after cardiac arrest as a „sepsis-like“ syndrome?. Circulation 2002; 106: 562-568 8 Lampe JW, Becker LB. State of the art in therapeutic hypothermia. Annu Rev Med 2011; 62: 79-93 9 Idris AH, Roberts 2nd LJ, Caruso L et al. Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and reperfusion. Crit Care Med 2005; 33: 2043-2048 10 Neumar RW, Nolan JP, Adrie C et al. Post cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication. Circulation 2008; 118: 2452-2483 11 Böttiger BW, Motsch J, Böhrer H et al. Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis. Circulation 1995; 92: 2572-2578 12 Geppert A, Zorn G, Delle Karth G et al. Soluble selectins and the systemic inflammatory response syndrome after successful cardiopulmonary resuscitation. Crit Care Med 2000; 28: 2360-2365 13 Laurent I, Monchi M, Chiche JD et al. Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol 2002; 40: 2110-2116 14 Böttiger BW, Motsch J, Braun V et al. Marked activation of complement and leukocytes and an increase in the concentrations of soluble endothelial adhesion molecules during cardiopulmonary resuscitation and early reperfusion after cardiac arrest in humans. Crit Care Med 2002; 30: 2473-2480 15 Fink K, Schwarz M, Feldbrügge L et al. Severe endothelial injury and subsequent repair in patients after successful cardiopulmonary resuscitation. Crit Care 2010; 14: R104 16 Takasu A, Saitoh D, Kaneko N et al. Hyperthermia: is it an ominous sign after cardiac arrest?. Resuscitation 2001; 49: 273-277 17 Langhelle A, Tyvold SS, Lexow K et al. In-hospital factors associated with improved outcome after out-of-hospital cardiac arrest: a comparison between four regions in Norway. Resuscitation 2003; 56: 247-263 18 Bisschops LLA, Hoedemaekers CWE, Mollnes TE et al. Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance. Crit Care Med 2012; 40: 1136-1142 19 Adrie C, Laurent I, Monchi M et al. Postresuscitation disease after cardiac arrest: a sepsis-like syndrome?. Curr Opin Crit Care 2004; 10: 208-212 20 Homer-Vanniasinkam S, Crinnion JN, Cough MJ. Post-ischaemic organ dysfunction: a review. Eur J Vasc Endovasc Surg 1997; 14: 195-203 21 Fink K, Feldbrügge L, Schwarz M et al. Circulating annexin V positive microparticles in patients after successful cardiopulmonary resuscitation. Crit Care 2011; 15: R251 22 Gando S, Nanzaki S, Morimoto Y et al. Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury. Intensive Care Med 2000; 26: 38-44 23 Gando S, Nanzaki S, Morimoto Y et al. Tissue factor and tissue factor pathway inhibitor levels during and after cardiopulmonary resuscitation. Thromb Res 1999; 96: 107-113 24 Adrie C, Monchi M, Laurent I et al. Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway. J Am Coll Cardiol 2005; 46: 21-28 25 Suk K, Cha S. Thrombin-induced interleukin-8 production and its regulation by interferon-γ and prostaglandin E2 in human monocytic U937 cells. Immunol Lett 1999; 67: 223-227 26 Senden NH, Jeunhomme TM, Heemskerk JW et al. Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. J Immunol 1998; 161: 4318-4324 27 van Genderen ME, Lima A, Akkerhuis M et al. Persistent peripheral and microcirculatory perfusion alterations after out-of-hospital cardiac arrest are associated with poor survival. Crit Care Med 2012; 40: 2287-2294 28 Omar YG, Massey M, Andersen LW et al. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation 2013; 84: 1717-1722 29 Roberts BW, Kilgannon JH, Chansky ME et al. Multiple Organ Dysfunction After Return of Spontaneous Circulation in Postcardiac Arrest Syndrome. Crit Care Med 2013; 41: 1492-1501 30 Qian J, Yang Z, Cahoon J et al. Post-resuscitation intestinal microcirculation: Its relationship withsublingual microcirculation and the severity of post-resuscitationsyndrome. Resuscitation 2014; [ePub ahead of print] 31 Seder DB, May T. The biochemical milieu after cardiac arrest: Moving toward tailored postresuscitation care. Crit Care Med 2012; 40: 1349-1351 32 Hartveit F, Halleraker B. Intravascular changes in kidneys and lungs after external cardiac massage: a preliminary report. Pathol 1970; 102: 54-58 33 Hekmatpanah J. Cerebral blood flow dynamics in hypotension and cardiac arrest. Neurology 1973; 23: 174-180 34 Cavaillon JM, Adrie C, Fitting C et al. Endotoxin tolerance: is there a clinical relevance?. J Endotoxin Res 2003; 9: 101-107 35 Munford RS, Pugin J. Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 2001; 163: 316-321 36 Tsai MS, Chiang WC, Lee CC et al. Infections in the survivors of out-of-hospital cardiac arrest in the first 7 days. Intensive Care Med 2005; 31: 621-626 37 Pene F, Hyvernat H, Mallet V et al. Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest. Intensive Care Med 2005; 31: 627-633 38 Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003; 348: 727-734 39 Ruiz-Bailén M, Aguayo de Hoyos E, Ruiz-Navarro S et al. Reversible myocardial dysfunction after cardiopulmonary resuscitation. Resuscitation 2005; 66: 175-181 40 Bougouin W, Cariou A. Management of postcardiac arrest myocardial dysfunction. Curr Opin Crit Care 2013; 19: 195-201 41 Kern KB, Hilwig RW, Rhee KH et al. Myocardial Dysfunction After Resuscitation From Cardiac Arrest: An Example of Global Myocardial Stunning. JACC 1996; 28: 232-240 42 Huang Y, He Q, Zhan L et al. Sarcoplasmic Phospholamban Protein Is Involved in the Mechanisms of Postresuscitation Myocardial Dysfunction and the Cardioprotective Effect of Nitrite during Resuscitation. PLOSone 2012; 8: e82552 43 Crow MT, Mani K, Nam YJ et al. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 2004; 95: 957-970 44 Chang WT, Ma MH, Chien KL et al. Postresuscitation myocardial dysfunction: correlated factors and prognostic implications. Intensive Care Med 2007; 33: 88-95 45 Gaieski DF, Band RA, Abella BS et al. Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest. Resuscitation 2009; 80: 418-424 46 Hochman JS, Sleeper LA, Webb JG et al. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. JAMA 2006; 295: 2511-2515 47 Gräsner JT, Meybohm P, Caliebe A et al. Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis. Crit Care 2011; 15: R61 48 Anyfantakis ZA, Baron G, Aubry P et al. Acute coronary angiographic findings in survivors of out-of-hospital cardiac arrest. Am Heart J 2009; 157: 312-318 49 Dumas F, Cariou A, Manzo-Silberman S et al. Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT registry. Circ Cardiovasc Interv 2010; 3: 200-207 50 Spaulding CM, Joly LM, Rosenberg A et al. Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. N Engl J Med 1997; 336: 1629-1633 51 Neumar RW. Molecular Mechanisms of Ischemic Neuronal Injury. Ann Emerg Med 2000; 36: 483-506 52 Binks A, Nolan JP. Post-cardiac arrest syndrome. Minerva Anestesiol 2010; 76: 362-368 53 Trzeciak S, Jones AE, Kilgannon JH et al. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med 2009; 37: 2895-2903 ; quiz 2904 54 Kilgannon JH, Jones AE, Shapiro NI et al. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303: 2165 55 Rossetti AO, Logroscino G, Liaudet L et al. Status epilepticus: An independent outcome predictor after cerebral anoxia. Neurology 2007; 69: 255-260 56 Zeiner A, Holzer M, Sterz F et al. Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med 2001; 161: 2007-2012 57 Pilcher J, Weatherall M, Shirtcliffe P et al. The effect of hyperoxia following cardiac arrest – A systematic review and meta-analysis of animal trials. Resuscitation 2012; 83: 417-422 58 Sandroni C, Cavallaro F, Callaway C et al. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: A systematic review and meta-analysis. Resuscitation 2013; 84: 1324-1338 59 Müllner M, Sterz F, Binder M et al. Blood glucose concentration after cardiopulmonary resuscitation influences functional neurological recovery in human cardiac arrest survivors. J Cereb Blood Flow Metab 1997; 17: 430-436 60 Wass CT, Scheithauer BW, Bronk JT et al. Insulin treatment of corticosteroid-associated hyperglycemia and its effect on outcome after forebrain ischemia in rats. Anesthesiology 1996; 84: 644-651 61 Katz LM, Wang Y, Ebmeyer U et al. Glucose plus insulin infusion improves cerebral outcome after asphyxial cardiac arrest. Neuroreport 1998; 9: 3363-3367 62 Bisschops LLA, Pop GAM, Teerenstra S et al. Effects of Viscosity on Cerebral Blood Flow After Cardiac Arrest. Crit Care Med 2014; 42: 632-637 63 Laver S, Farrow C, Turner D et al. Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 2004; 30: 2126-2128 64 Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 557-563 65 Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549-556 66 Holzer M, Bernard SA, Hachimi-Idrissi S et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med 2005; 33: 414-418 67 Arrich J, Holzer M, Havel C et al. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2012; 68 Hachimi-Idrissi S, Corne L, Ebinger G et al. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation 2001; 51: 275-281 69 Inamasu J, Suga S, Sato S et al. Intra-ischemic hypothermia attenuates intercellular adhesion molecule-1 (ICAM-1) and migration of neutrophil. Neurol Res 2001; 23: 105-111 70 Han HS, Qiao Y, Karabiyikoglu M et al. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 2002; 22: 3921-3928 71 Takata K, Takeda Y, Sato T et al. Effects of hypothermia for a short period on histologic outcome and extracellular glutamate concentration during and after cardiac arrest in rats. Crit Care Med 2005; 33: 1340-1345 72 Shao ZH, Chang WT, Chan KC et al. Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling. Am J Physiol Heart Circ Physiol 2007; 292: H1995-2003 73 Kim F, Nichol G, Maynard C et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. JAMA 2014; 311: 45-52 74 Nielsen N, Wetterslev J, Cronberg T et al. Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest. N Engl J Med 2013; 369: 2197-2206 75 Ma L, Lu X, Xu J et al. Improved cardiac and neurologic outcomes with postresuscitation infusion of cannabinoid receptor agonist WIN55, 212-2 depend on hypothermia in a rat model of cardiac arrest. Crit Care Med 2014; 42: e42-48 76 Fosgerau K, Weber UJ, Gotfredsen JW et al. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc Disord 2010; 10: 51 77 Katz LM, Frank JE, McGwin Jr G et al. Induction of a Prolonged Hypothermic State by Drug-induced Reduction in the Thermoregulatory Set-Point. Ther Hypothermia Temp Manag 2012; 2: 61-66 78 Sunde K, Pytte M, Jacobsen D et al. (eds.) Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 2007; 73: 29-39 79 Damian MS, Ellenberg D, Gildemeister R et al. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation 2004; 110: 3011-3016 80 Zhang F, Yu W, Hargrove JL et al. Inhibition of TNF-α induced ICAM-1, VCAM-1 and E-selectin expression by selenium. Atherosclerosis 2002; 161: 381-386 81 Reisinger J, Höllinger K, Lang W et al. Does early administration of selenium improve neurological outcome after cardiac arrest?. Am J Emerg Med 2009; 27: 176-181 82 Tsai MS, Huang CH, Tsai CY et al. Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat. Acad Emerg Med 2014; 21: 257-265 83 Minamishima S, Kida K, Tokuda K et al. Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice. Circulation 2011; 124: 1645-1653 84 Hayashida K, Sano M, Kamimura N et al. H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 2012; 1: e003459 85 Laurent I, Adrie C, Vinsonneau C et al. High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study. J Am Coll Cardiol 2005; 46: 432-437 86 Böttiger BW, Grabner C, Bauer H et al. Long term outcome after out-of-hospital cardiac arrest with physician staffed emergency medical services: the Utstein style applied to a midsized urban/suburban area. Heart 1999; 82: 674-679 87 Iskander KN et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev 2013; 93: 1247-1288
