Synlett 2014; 25(15): 2087-2092
DOI: 10.1055/s-0034-1378244
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© Georg Thieme Verlag Stuttgart · New York

Microflow Technology: Another Solution for the Site-Selective Modification of Multifunctionalized Molecules

Shinichiro Fuse*
a   Department of Applied Chemistry, Tokyo Institute of Technology 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan   Fax: +81(3)57342884   eMail: sfuse@apc.titech.ac.jp
,
Yuto Mifune
a   Department of Applied Chemistry, Tokyo Institute of Technology 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan   Fax: +81(3)57342884   eMail: sfuse@apc.titech.ac.jp
,
Nobutake Tanabe
a   Department of Applied Chemistry, Tokyo Institute of Technology 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan   Fax: +81(3)57342884   eMail: sfuse@apc.titech.ac.jp
,
Takashi Takahashi
b   Yokohama College of Pharmacy 601, Matana-cho, Totsuka-ku, Yokohama-shi 245-0066, Japan
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Publikationsverlauf

Received: 11. April 2014

Accepted after revision: 05. Mai 2014

Publikationsdatum:
24. Juni 2014 (online)


Abstract

The synthesis of multifunctionalized organic molecules is challenging because multiple functional groups frequently causes unexpected side reactions. The recent emergence of microflow technology has offered a new solution to this problem. Herein, we wish to describe our recent achievements in the microflow synthesis of multifunctionalized molecules such as vitamin D and peptides.