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Synthesis 2014; 46(22): 3121-3132
DOI: 10.1055/s-0034-1378454
DOI: 10.1055/s-0034-1378454
paper
A Palladium on Carbon Catalyzed One-Pot Synthesis of Substituted Benzimidazoles
Further Information
Publication History
Received: 10 December 2013
Accepted after revision: 22 June 2014
Publication Date:
30 July 2014 (online)
Abstract
A new and efficient palladium on carbon catalyzed one-pot intramolecular nitro reduction/cyclization reaction has been developed for the preparation of a series of substituted benzimidazoles, including some novel ring-fused [1,2-a]-tricyclic, [1,2-a]-tetracyclic, and chiral benzimidazoles. The main advantages of this method are the mild and simple reaction conditions, the easy isolation of the products, and the excellent yields. The reaction has the potential to be used as a general procedure for the preparation of 7-aminobenzimidazoles in good yields. A plausible mechanism for the reaction is proposed.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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For the use of palladium and related metal-catalyzed reactions to prepare heterocycles, see: