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Synthesis 2014; 46(23): 3256-3262
DOI: 10.1055/s-0034-1378635
DOI: 10.1055/s-0034-1378635
paper
Thioacetamide as an Ammonium Source for Multicomponent Synthesis of Pyridines from Aldehydes and Electron-Deficient Enamines or Alkynes
Further Information
Publication History
Received: 13 June 2014
Accepted after revision: 17 July 2014
Publication Date:
21 August 2014 (online)
Abstract
A generally applicable multicomponent method has been established for the synthesis of pyridines. In the reactions, thioacetamide is used as a cheap and efficient ammonium source in a multicomponent reaction with aldehydes and electron-deficient enamines or alkynes to give 3,4,5-trisubstituted pyridines in moderate to good yields and with a high product diversity.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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For selected recent leading examples on pyridine synthesis, see: