Abstract
A large number of significant bioactive natural and synthetic alkyl(methyl)maleic anhydrides are known in the contemporary literature. A broad range of suitably functionalized substrates have been tailored to accomplish concise and efficient syntheses of an array of alkyl(methyl)maleic anhydrides employing a variety of elegant synthetic strategies. This review presents a brief literature account of the isolation and activity of these important target compounds with a special emphasis on their synthesis.
1 Introduction
2 Recent Synthetic Strategies towards the Natural and Unnatural Alkyl(methyl)maleic Anhydrides
2.1 Dimethylmaleic Anhydride
2.2 Ethyl/hexyl/octyl(methyl)maleic Anhydrides
2.3 Chaetomellic Anhydrides A–C
2.4 Tyromycin A
2.5 Aspergillus Acids A–D
2.6 Tautomycin and Tautomycetin
2.7 Lindenanolide E, Itaconitin, Graphenone and 2,3-Didehydrotelfairic Anhydride
2.8 Synthetic Analogues of Alkyl(methyl)maleic Anhydrides
3 Summary
Key words
dimethylmaleic anhydride - alkyl(methyl)maleic anhydrides - isolation - bioactivity - nucleophilic reactions - total synthesis
