Recent Advances in Iodine Monochloride Mediated Electrophilic Cyclizations

Abstract

Recent progress in electrophilic cyclizations has led to the development of many electrophilic cyclizing agents. Among them, iodine monochloride (ICl) has recently emerged as one of the most promising. In this Review, we highlight the advances in iodine monochloride mediated electrophilic cyclizations from 2000 to 2014. In addition, the different transformations of organoiodine compounds (the usual products of these electrophilic cyclizations) are discussed.

1 Introduction

2 Iodine Monochloride Mediated Electrophilic Cyclizations

2.1 Synthesis of Quinoline and Isoquinoline Derivatives

2.2 Synthesis of Isocoumarins and α-Pyrone Derivatives

2.3 Synthesis of Furan Derivatives

2.4 Synthesis of Isoxazoles

2.5 Synthesis of Selenium-Containing Compounds

2.6 Synthesis of Phosphorus-Containing Compounds

2.7 Synthesis of Spiro Compounds

2.8 Synthesis of Polysubstituted Aromatic Compounds

2.9 Miscellaneous

3 Summary and Outlook

Key words

electrophilic cyclizations - iodine monochloride - iodonium ion - iodocyclizations - intramolecular cyclizations - organoiodine compounds

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