Abstract
Developing eco-friendly, stable, and easy-to-handle acyl sources is of great importance
in synthetic and green chemistry. This study describes the synthesis of benzo[d]azol-2(3H)-ones such as benzo[d]thiazol-2(3H)-ones, benzo[d]oxazol-2(3H)-ones, and benzo[d]imidazol-2(3H)-ones using 2-phenoxycarbonyl-4,5-dichloropyridazin-3(2H)-one in one pot. The reaction reported is carried out under neutral or acidic conditions
in the presence of zinc or sodium bicarbonate to give the corresponding heterocycles
in good to excellent yields. The reaction uses a solid stable carbonyl source that
is a recyclable functional-group carrier, pyridazin-3(2H)-one.
Key words
carbonylation - green chemistry - heterocycles - medicinal chemistry - ring closure